Genetic determinants of facial clefting: analysis of 357 candidate genes using two national cleft studies from Scandinavia.

Autor: Astanand Jugessur, Min Shi, Håkon Kristian Gjessing, Rolv Terje Lie, Allen James Wilcox, Clarice Ring Weinberg, Kaare Christensen, Abee Lowman Boyles, Sandra Daack-Hirsch, Truc Nguyen Trung, Camilla Bille, Andrew Carl Lidral, Jeffrey Clark Murray

Publikováno v: PLoS ONE, Vol 4, Iss 4, p e5385 (2009)

BackgroundFacial clefts are common birth defects with a strong genetic component. To identify fetal genetic risk factors for clefting, 1536 SNPs in 357 candidate genes were genotyped in two population-based samples from Scandinavia (Norway: 562 case-

Externí odkaz: https://doaj.org/article/194b12b88b504cbc804632c1c23c1b11

Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study

Autor: Truc Nguyen Trung, Anne Marte W. Johansen, Allen J. Wilcox, Jack A. Taylor, Clarice R. Weinberg, Stein Emil Vollset, Per Magne Ueland, Håkon K. Gjessing, Rolv T. Lie, Abee L. Boyles, Klaus Meyer, Jeffrey C. Murray, Astanand Jugessur, Kaare Christensen, Åse Fredriksen, Min Shi, Christian A. Drevon

Publikováno v: Boyles, A L, Wilcox, A J, Taylor, J A, Shi, M, Weinberg, C R, Meyer, K, Fredriksen, A, Ueland, P M, Johansen, A M W, Drevon, C A, Jugessur, A, Trung, T N, Gjessing, H K, Vollset, S E, Murray, J C, Christensen, K & Lie, R T 2009, ' Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A : a pathway-wide association study ', Genetic Epidemiology, vol. 33, no. 3, pp. 247-255 . https://doi.org/10.1002/gepi.20376

Udgivelsesdato: 2009-Apr An increased risk of facial clefts has been observed among mothers with lower intake of folic acid or vitamin A around conception. We hypothesized that the risk of clefts may be further moderated by genes involved in metaboli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23d15ae40b545c2d66974430206b744
https://doi.org/10.1002/gepi.20376

Genetic Determinants of Facial Clefting: Analysis of 357 Candidate Genes Using Two National Cleft Studies from Scandinavia.

Autor: Jugessur, Astanand, Min Shi, Gjessing, Håkon Kristian, Rolv Terje Lie, Wilcox, Allen James, Weinberg, Clarice Ring, Christensen, Kaare, Boyles, Abee Lowman, Daack-Hirsch, Sandra, Truc Nguyen Trung, Bille, Camilla, Lidral, Andrew Carl, Murray, Jeffrey Clark

Publikováno v: PLoS ONE; 2009, Vol. 4 Issue 4, p1-11, 11p, 3 Diagrams, 1 Graph