Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Truc Chi T. Pham"'
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 2, Pp 2788-2807 (2013)
G protein-coupled receptor (GPCR) structures are of interest as a means to understand biological signal transduction and as tools for therapeutic discovery. The growing number of GPCR crystal structures demonstrates that the extracellular loops (EL)
Externí odkaz:
https://doaj.org/article/c337f62718fd4588a1b83fbbb36e1aa7
Autor:
Souvik Banerjee, Derek D. Norman, Sue Chin Lee, Daniel L. Baker, Gabor Tigyi, Truc Chi T. Pham, Abby L. Parrill, Duane D. Miller
Publikováno v:
J Med Chem
Autotaxin (ATX, aka. ENPP2) is the main source of the lipid mediator lysophosphatidic acid (LPA) in biological fluids. This study reports on inhibitors of ATX derived by lead optimization of the benzene-sulfonamide in silico hit compound 3. The new a
Autor:
Robert Bittman, Duane D. Miller, Sandra Nelson, Truc Chi T. Pham, Ryoko Tsukahara, R. Jason Kirby, Renukadevi Patil, Gabor Tigyi, Derek D. Norman, Daniel L. Baker, Abby L. Parrill, William L. Seibel, Sue Chin Lee, James I. Fells, Ruben Papoian
Publikováno v:
FEBS Journal. 281:1017-1028
Modulation of autotaxin (ATX), the lysophospholipase D enzyme that produces lysophosphatidic acid, with small-molecule inhibitors is a promising strategy for blocking the ATX-lysophosphatidic acid signaling axis. Although discovery campaigns have bee
Publikováno v:
Biopolymers. 86:298-310
G protein-coupled receptors (GPCRs) control fundamental aspects of human physiology and behaviors. Knowledge of their structures, especially for the loop regions, is limited and has principally been obtained from homology models, mutagenesis data, lo
Autor:
Yuichi Inagaki, Abby L. Parrill, Yuko Fujiwara, Yasuyuki Igarashi, Takayuki Kohno, Truc Chi T. Pham, Daniel A. Osborne, Gabor Tigyi
Publikováno v:
Biochemical Journal. 389:187-195
Synergistic computational and experimental studies provided previously unforeseen details concerning the structural basis of S1P (sphingosine 1-phosphate) recognition by the S1P4 G-protein-coupled receptor. Similarly to reports on the S1P1 receptor,
Publikováno v:
Biochimica et biophysica acta. 1831(1)
Sphingosine kinases 1 and 2 (SK1 and SK2) generate the bioactive lipid mediator sphingosine 1-phosphate and as such play a significant role in cell fate and in human health and disease. Despite significant interest in and examination of the role play
Autor:
Xuan Zhao, John C. Bollinger, Hongyu Zhou, Shiliang Tian, Bing Yan, Teera Baine, Shotaro Kudo, Nathan J. DeYonker, Truc Chi T. Pham, Wangkheimayum Marjit Singh, Charles Edwin Webster, Xuan Anh N. Ma, Daniel L. Baker
Publikováno v:
Angewandte Chemie (International ed. in English). 51(24)
Publikováno v:
BMC Biochemistry, Vol 12, Iss 1, p 65 (2011)
BMC Biochemistry
BMC Biochemistry
Background Nucleotide pyrophosphatase/phosphodiesterase 7 (NPP7) is the only member of the mammalian NPP enzyme family that has been confirmed to act as a sphingomyelinase, hydrolyzing sphingomyelin (SM) to form phosphocholine and ceramide. NPP7 addi
Autor:
Yuko Fujiwara, Truc Chi T. Pham, Jianxiong Liu, Daniel L. Baker, Yaohong Wang, Abby L. Parrill, Renukadevi Patil, Karin Emmons-Thompson, Nattapon Panupinthu, Gabor Tigyi, Anjaih Siddam, James I. Fells, Alyssa L. Bolen, C. Ryan Yates, Duane D. Miller, Sue C. Lee, Gordon B. Mills, Renuka Gupte
Publikováno v:
ChemMedChem. 6(5)
Autotaxin (ATX, NPP2) is a member of the nucleotide pyrophosphate phosphodiesterase enzyme family. ATX catalyzes the hydrolytic cleavage of lysophosphatidylcholine (LPC) by lysophospholipase D activity, which leads to generation of the growth-factor-
Autor:
Yuko Fujiwara, Daniel L. Baker, Duane D. Miller, Anjaih Siddam, Susumu Kobayashi, Gabor Tigyi, Yan Lu, Nattapon Panupinthu, Kimiko Murakami-Murofushi, Renuka Gupte, Mari Gotoh, Wei Li, Gordon B. Mills, Abby L. Parrill, Truc Chi T. Pham
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(24)
Cyclic phosphatidic acid (CPA) is a naturally occurring analog of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a five-membered ring with the sn-3 phosphate. Here, we describe the synthesis of R-3-CCPA and S-3-CCPA along with thei