Zobrazeno 1 - 10
of 436
pro vyhledávání: '"Trpml1"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Neuronal death was frequently driven by autophagic/lysosomal dysfunction after ischemic stroke, whereas how to restore the impaired autophagic flux remained elusive. Autophagic/lysosomal signaling could be augmented after transcription facto
Externí odkaz:
https://doaj.org/article/ed1f662750754d7a851db6903e979242
Autor:
Valentina Brunetti, Roberto Berra-Romani, Filippo Conca, Teresa Soda, Gerardo Rosario Biella, Andrea Gerbino, Francesco Moccia, Giorgia Scarpellino
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Lysosomal Ca2+ signaling is emerging as a crucial regulator of endothelial Ca2+ dynamics. Ca2+ release from the acidic vesicles in response to extracellular stimulation is usually promoted via Two Pore Channels (TPCs) and is amplified by endoplasmic
Externí odkaz:
https://doaj.org/article/90642c6ba2bf41c69d19c35bf444b1fe
Autor:
Madison L. Sangster, Martha M. Bishop, Yizheng Yao, Jessica F. Feitor, Sanjid Shahriar, Maxwell E. Miller, Anil K. Chekuri, Bogdan Budnik, Fengfeng Bei, Yulia Grishchuk
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101269- (2024)
Mucolipidosis IV (MLIV) is a rare, autosomal recessive, lysosomal disease characterized by intellectual disability, motor deficits, and progressive vision loss. Using adeno-associated vector 9 (AAV9) and AAV-PHP.B as delivery vectors, we previously d
Externí odkaz:
https://doaj.org/article/e7cd057cd76f4b5bae5aa926b9586f15
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8829 (2024)
The lysosomal Ca2+ channel TRPML1 was found to be responsible for gastric acid secretion in murine gastric parietal cells by inducing the trafficking of H+/K+-ATPase containing tubulovesicles to the apical membrane. Therefore, we hypothesized a simil
Externí odkaz:
https://doaj.org/article/8f71dff48b094e8a9b117e0e35975e1e
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Triple-negative breast cancer (TNBC) is the most refractory subtype of breast cancer, and effective treatments are urgently needed owing to its poor prognosis. Surgery, radiotherapy, and chemotherapy, alone or in combination, are the leading choices
Externí odkaz:
https://doaj.org/article/6f4ae59e4d464565b844947b1854170c
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Intracellular pathogens establish persistent infections by generating reservoirs that protect them from the action of antibiotics and the host immune response. Novel therapeutics should then target the host pathways exploited by the pathogens to form
Externí odkaz:
https://doaj.org/article/f555bebf92794c4e963488f22a00f131
Autor:
Boyun Kim, Jewon Jung
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 865 (2024)
Pancreatic cancer is characterized by its high mortality rate and limited treatment options, often driven by oncogenic RAS mutations. In this study, we investigated the metabolomic profiles of pancreatic cancer cells based on their KRAS genetic statu
Externí odkaz:
https://doaj.org/article/8cda0c5b3562452487050d48c73235a4
Akademický článek
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Publikováno v:
Toxicology Reports, Vol 10, Iss , Pp 529-536 (2023)
Zinc oxide nanoparticles (ZnO NPs) have been widely used in various materials including sunscreens, cosmetics, over-the-counter topical skin products, and pigments. As traces of the used ZnO NPs have been found in the kidney, it is crucial to uncover
Externí odkaz:
https://doaj.org/article/b7700985cede494a94469f940d942065
Autor:
Madison Sangster, Sanjid Shahriar, Zachary Niziolek, Maria Carla Carisi, Michael Lewandowski, Bogdan Budnik, Yulia Grishchuk
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Mucolipidosis IV (MLIV) is an ultra-rare, recessively inherited lysosomal disorder resulting from inactivating mutations in MCOLN1, the gene encoding the lysosomal cation channel TRPML1. The disease primarily affects the central nervous system (CNS)
Externí odkaz:
https://doaj.org/article/1273565b6a844f56b8aaccfa74f9fe3e