Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Troy W. Whitfield"'
Autor:
Lisa L. Hall, Meg Byron, Dawn M. Carone, Troy W. Whitfield, Gayle P. Pouliot, Andrew Fischer, Peter Jones, Jeanne B. Lawrence
Publikováno v:
Cell Reports, Vol 18, Iss 12, Pp 2943-2956 (2017)
This study reveals that high-copy satellite II (HSATII) sequences in the human genome can bind and impact distribution of chromatin regulatory proteins and that this goes awry in cancer. In many cancers, master regulatory proteins form two types of c
Externí odkaz:
https://doaj.org/article/875f056d7ee342b8bb9bb523f3ebfebc
Publikováno v:
PLoS Genetics, Vol 20, Iss 6, p e1011241 (2024)
Although introns are typically tens to thousands of nucleotides, there are notable exceptions. In flies as well as humans, a small number of genes contain introns that are more than 1000 times larger than typical introns, exceeding hundreds of kiloba
Externí odkaz:
https://doaj.org/article/650614c4b12740209033fe31b1884c0f
Autor:
Kyle Vaccaro, Juliet Allen, Troy W. Whitfield, Asaf Maoz, Sarah Reeves, José Velarde, Dian Yang, Nicole Phan, George W. Bell, Aaron N. Hata, Kipp Weiskopf
Macrophage immune checkpoint inhibitors, such as anti-CD47 antibodies, show promise in clinical trials for solid and hematologic malignancies. However, the best strategies to use these therapies remain unknown and ongoing studies suggest they may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddb0b5dc241ecb4be55bfd6edb97590e
https://doi.org/10.1101/2023.03.03.531059
https://doi.org/10.1101/2023.03.03.531059
Autor:
Zsolt G. Venkei, Ildar Gainetdinov, Margaret R. Starostik, Charlotte P. Choi, Peiwei Chen, Chiraag Balsara, Troy W. Whitfield, George W. Bell, Suhua Feng, Steven E. Jacobsen, Alexei A. Aravin, John K. Kim, Philip D. Zamore, Yukiko M. Yamashita
PIWI-interacting RNAs (piRNAs) direct PIWI proteins to silence complementary targets such as transposons. In animals with a maternally specified germline, e.g. Drosophila melanogaster, maternally deposited piRNAs initiate piRNA biogenesis in the prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e070a1697a4eb957f51699f9abc98d1
https://doi.org/10.1101/2022.09.12.507655
https://doi.org/10.1101/2022.09.12.507655
Autor:
Marine A. Krzisch, Hao Wu, Bingbing Yuan, Troy W. Whitfield, X. Shawn Liu, Dongdong Fu, Carrie M. Garrett-Engele, Andrew S. Khalil, Tenzin Lungjangwa, Jennifer Shih, Aaron N. Chang, Stephen Warren, Angela Cacace, Kristin R. Andrykovich, Rosalie G.J. Rietjens, Owen Wallace, Mriganka Sur, Bhav Jain, Rudolf Jaenisch
Publikováno v:
Biological psychiatry. 93(1)
Fragile X syndrome (FXS) is characterized by physical abnormalities, anxiety, intellectual disability, hyperactivity, autistic behaviors, and seizures. Abnormal neuronal development in FXS is poorly understood. Data on patients with FXS remain scarce
Autor:
Mriganka Sur, Angela Cacace, Dongdong Fu, Aaron N. Chang, Rudolf Jaenisch, Jennifer Shih, Bingbing Yuan, Carrie M. Garrett-Engele, X. Shawn Liu, Kristin R. Andrykovich, Bhav Jain, Hao Wu, Troy W. Whitfield, Marine Krzisch, Rosalie G. J. Rietjens, Stephen T. Warren, Wallace Owen Brendan
Abnormal neuronal development in Fragile X syndrome (FXS) is poorly understood. Data on FXS patients remain scarce and FXS animal models have failed to yield successful therapies. In vitro models do not fully recapitulate the morphology and function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0ee7510fb36960d0bd667cd7f6496be
https://doi.org/10.1101/2021.09.27.461739
https://doi.org/10.1101/2021.09.27.461739
Publikováno v:
J Chem Theory Comput
Over the past several decades, atomistic simulations of biomolecules, whether carried out using molecular dynamics or Monte Carlo techniques, have provided detailed insights into their function. Comparing the results of such simulations for a few clo
Autor:
N. KurtYilmaz, Troy W. Whitfield, Sook Kyung Lee, Debra A. Ragland, Ronald Swanstrom, Celia A. Schiffer, Konstantin B. Zeldovich
Publikováno v:
Journal of Chemical Theory and Computation. 13:5671-5682
HIV-1 protease is responsible for the cleavage of 12 non-homologous sites within the Gag and Gag-Pro-Pol polyproteins in the viral genome. Under the selective pressure of protease inhibition, the virus evolves mutations within (primary) and outside o
Autor:
Celia A. Schiffer, Daniel N. Bolon, Ellen A. Nalivaika, Troy W. Whitfield, Gily S. Nachum, Mina Henes, Nese Kurt Yilmaz, Klajdi Kosovrasti, Florian Leidner, Gordon J. Lockbaum
Publikováno v:
Biochemistry
Protease inhibitors have the highest potency among antiviral therapies against HIV-1 infections, yet the virus can evolve resistance. Darunavir (DRV), currently the most potent Food and Drug Administration-approved protease inhibitor, retains potency
Autor:
Celia A. Schiffer, Jeremy Luban, Jeffrey I. Boucher, Daniel N. Bolon, Ronald Swanstrom, Gily S. Nachum, Konstantin B. Zeldovich, Ann Dauphin, Troy W. Whitfield, Carl Hollins
The evolution of HIV-1 protein sequences should be governed by a combination of factors including nucleotide mutational probabilities, the genetic code, and fitness. The impact of these factors on protein sequence evolution is interdependent, making
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1465badd60e00adfd47db74aab4f9bc7