Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Troy Taylor"'
Autor:
Matthew Smith, José Sánchez Hernández, Simon Messing, Nitya Ramakrishnan, Brianna Higgins, Jennifer Mehalko, Shelley Perkins, Vanessa E. Wall, Carissa Grose, Peter H. Frank, Julia Cregger, Phuong Vi Le, Adam Johnson, Mukul Sherekar, Morgan Pagonis, Matt Drew, Min Hong, Stephanie R. T. Widmeyer, John-Paul Denson, Kelly Snead, Ivy Poon, Timothy Waybright, Allison Champagne, Dominic Esposito, Jane Jones, Troy Taylor, William Gillette
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract The diversity of chemical and structural attributes of proteins makes it inherently difficult to produce a wide range of proteins in a single recombinant protein production system. The nature of the target proteins themselves, along with cos
Externí odkaz:
https://doaj.org/article/d73bb5aac7c74a0792d3cbf25a30ef55
Autor:
Fa-An Chao, Albert H. Chan, Srisathiyanarayanan Dharmaiah, Charles D. Schwieters, Timothy H. Tran, Troy Taylor, Nitya Ramakrishnan, Dominic Esposito, Dwight V. Nissley, Frank McCormick, Dhirendra K. Simanshu, Gabriel Cornilescu
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Localized dynamics of RAS, including regions distal to the nucleotide-binding site, is of high interest for elucidating the mechanisms by which RAS proteins interact with effectors and regulators and for designing inhibitors. Among several o
Externí odkaz:
https://doaj.org/article/69321b8535d54b5689b2d175700764dc
Autor:
Timothy H. Tran, Albert H. Chan, Lucy C. Young, Lakshman Bindu, Chris Neale, Simon Messing, Srisathiyanarayanan Dharmaiah, Troy Taylor, John-Paul Denson, Dominic Esposito, Dwight V. Nissley, Andrew G. Stephen, Frank McCormick, Dhirendra K. Simanshu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The molecular details of the RAS-RAF interaction are still not fully understood. Here, the authors present crystal structures of wild-type and mutant KRAS in complex with the RAS-binding and membrane-interacting cysteine-rich domains of RAF1, and pro
Externí odkaz:
https://doaj.org/article/8075c5993bfb4f61bc8bb5d453321337
Autor:
Ying Fu, Juliana da Fonseca Rezende E Mello, Bryan D Fleming, Alex Renn, Catherine Z Chen, Xin Hu, Miao Xu, Kirill Gorshkov, Quinlin Hanson, Wei Zheng, Emily M Lee, Lalith Perera, Robert Petrovich, Manisha Pradhan, Richard T Eastman, Zina Itkin, Thomas B Stanley, Allen Hsu, Venkata Dandey, Kedar Sharma, William Gillette, Troy Taylor, Nitya Ramakrishnan, Shelley Perkins, Dominic Esposito, Eunkeu Oh, Kimihiro Susumu, Mason Wolak, Marc Ferrer, Matthew D Hall, Mario J Borgnia, Anton Simeonov
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272364 (2022)
Neutralizing antibodies targeting the SARS-CoV-2 spike protein have shown a great preventative/therapeutic potential. Here, we report a rapid and efficient strategy for the development and design of SARS-CoV-2 neutralizing humanized nanobody construc
Externí odkaz:
https://doaj.org/article/f2f1ebb6cd9a4991a32d3546fa2987d7
Autor:
Farid A. Siddiqui, Catharina Alam, Petja Rosenqvist, Mikko Ora, Ahmed Sabt, Ganesh babu Manoharan, Lakshman Bindu, Sunday Okutachi, Marie Catillon, Troy Taylor, Omaima M. Abdelhafez, Harri Lönnberg, Andrew G. Stephen, Anastassios C. Papageorgiou, Pasi Virta, Daniel Abankwa
Publikováno v:
ACS Omega, Vol 5, Iss 1, Pp 832-842 (2019)
Externí odkaz:
https://doaj.org/article/3c425549098741d9ab67574c49453cfb
Autor:
Fa-An Chao, Srisathiyanarayanan Dharmaiah, Troy Taylor, Simon Messing, William Gillette, Dominic Esposito, Dwight V. Nissley, Frank McCormick, R. Andrew Byrd, Dhirendra K. Simanshu, Gabriel Cornilescu
Publikováno v:
Journal of the American Chemical Society. 144:4196-4205
KRAS is the most frequently mutated RAS protein in cancer patients, and it is estimated that about 20% of the cancer patients in the United States carried mutant RAS proteins. To accelerate therapeutic development, structures and dynamics of RAS prot
Autor:
Nicolas W. Hengartner, Timothy H. Tran, Andrew G. Stephen, Daniel Scott, Oleg Chertov, Arvind Ramanathan, William K. Gillette, Debsindhu Bhowmik, Michael L. Gross, Mathias Lösche, Xiaoying Ye, Frank Heinrich, Que N. Van, Dhirendra K. Simanshu, Simon Messing, Marco Tonelli, Troy Taylor, Sandrasegaram Gnanakaran, John L. Markley, Patrick Alexander, Dominic Esposito, Christopher B. Stanley, Matt Drew, Ben Niu, Cesar A. Lopez, Dwight V. Nissley, William M. Westler, Peter Frank, Frank McCormick
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 39
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 39
The small GTPase KRAS is localized at the plasma membrane where it functions as a molecular switch, coupling extracellular growth factor stimulation to intracellular signaling networks. In this process, KRAS recruits effectors, such as RAF kinase, to
Autor:
Andrew G. Stephen, Farid Ahmad Siddiqui, Lakshman Bindu, Pasi Virta, Ganesh babu Manoharan, Mikko Ora, Marie Catillon, Catharina Alam, Daniel Abankwa, Omaima M. Abdelhafez, Anastassios C. Papageorgiou, Sunday Ojochegbe Okutachi, Ahmed Sabt, Harri Lönnberg, Petja Rosenqvist, Troy Taylor
Publikováno v:
ACS Omega, Vol 5, Iss 1, Pp 832-842 (2019)
ACS Omega
ACS Omega
The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in the perinuclear area is significant for correct K-Ras localization and
Autor:
Ying Fu, Juliana da Fonseca Rezende e Mello, Bryan D. Fleming, Alex Renn, Catherine Z. Chen, Xin Hu, Miao Xu, Kirill Gorshkov, Quinlin Hanson, Wei Zheng, Emily M. Lee, Lalith Perera, Robert Petrovich, Manisha Pradhan, Richard T. Eastman, Zina Itkin, Thomas B. Stanley, Allen Hsu, Venkata Dandey, Kedar Sharma, William Gillette, Troy Taylor, Nitya Ramakrishnan, Shelley Perkins, Dominic Esposito, Eunkeu Oh, Kimihiro Susumu, Mason Wolak, Marc Ferrer, Matthew D. Hall, Mario J. Borgnia, Anton Simeonov
Publikováno v:
bioRxiv
Neutralizing antibodies targeting the SARS-CoV-2 spike protein have shown a great preventative/therapeutic potential. Here, we report a rapid and efficient strategy for the development and design of SARS-CoV-2 neutralizing humanized nanobody construc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e229c55e6f9f11419c5c35925abed82
https://doi.org/10.1101/2021.10.22.465476
https://doi.org/10.1101/2021.10.22.465476
KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner
Autor:
Marco Tonelli, Simon Messing, Frank McCormick, Lakshman Bindu, Rodolfo Ghirlando, Constance Agamasu, Dwight V. Nissley, Troy Taylor, Andrew G. Stephen, Timothy H. Tran
Publikováno v:
Biophysical journal, vol 116, iss 6
Biophysical Journal
Biophysical Journal
Deregulation of KRAS4b signaling pathway has been implicated in 30% of all cancers. Membrane localization of KRAS4b is an essential step for the initiation of the downstream signaling cascades that guide various cellular mechanisms. KRAS4b plasma mem