Zobrazeno 1 - 10
of 241
pro vyhledávání: '"Troy R, Torgerson"'
Autor:
Samir Rachid Zaim, Mark-Phillip Pebworth, Imran McGrath, Lauren Okada, Morgan Weiss, Julian Reading, Julie L. Czartoski, Troy R. Torgerson, M. Juliana McElrath, Thomas F. Bumol, Peter J. Skene, Xiao-jun Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) is being increasingly used to study gene regulation. However, major analytical gaps limit its utility in studying gene regulatory programs in complex diseas
Externí odkaz:
https://doaj.org/article/510a659dc6a34101b8936defcaa98168
Autor:
Sarah Alice Long, Virginia S. Muir, Britta E. Jones, Valerie Z. Wall, Alyssa Ylescupidez, Anne M. Hocking, Stephan Pribitzer, Jerill Thorpe, Bryce Fuchs, Alice E. Wiedeman, Megan Tatum, Katharina Lambert, Hannes Uchtenhagen, Cate Speake, Bernard Ng, Alexander T. Heubeck, Troy R. Torgerson, Adam K. Savage, Michael A. Maldonado, Neelanjana Ray, Vadim Khaychuk, Jinqi Liu, Peter S. Linsley, Jane H. Buckner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Exhausted CD8 T cells (TEX) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT+KLRG1+ TEX with teplizumab therapy in type 1 diabetes (T1D), in the absence of treatment we f
Externí odkaz:
https://doaj.org/article/848afa4859044e9fb280078686f378e7
Autor:
Aarthi Talla, Suhas V. Vasaikar, Gregory Lee Szeto, Maria P. Lemos, Julie L. Czartoski, Hugh MacMillan, Zoe Moodie, Kristen W. Cohen, Lamar B. Fleming, Zachary Thomson, Lauren Okada, Lynne A. Becker, Ernest M. Coffey, Stephen C. De Rosa, Evan W. Newell, Peter J. Skene, Xiaojun Li, Thomas F. Bumol, M. Juliana McElrath, Troy R. Torgerson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Long COVID or post-acute sequelae of SARS-CoV-2 (PASC) is a clinical syndrome featuring diverse symptoms that can persist for months following acute SARS-CoV-2 infection. The aetiologies may include persistent inflammation, unresolved tissue
Externí odkaz:
https://doaj.org/article/0a4ada69f9a3464f8bb10065779fdcc5
Autor:
Suhas V. Vasaikar, Adam K. Savage, Qiuyu Gong, Elliott Swanson, Aarthi Talla, Cara Lord, Alexander T. Heubeck, Julian Reading, Lucas T. Graybuck, Paul Meijer, Troy R. Torgerson, Peter J. Skene, Thomas F. Bumol, Xiao-jun Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The analysis of longitudinal bulk and single-cell multi-omics data is a highly complex task. Here, the authors introduce PALMO, a software platform with five modules to analyse longitudinal bulk and single-cell multi-omics data, which is extensively
Externí odkaz:
https://doaj.org/article/9167378588ad444cbf7f985a5e41ce2a
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/62ab0b285871410ab5d44df79257d6e3
Autor:
Sara E Vazquez, Sabrina A Mann, Aaron Bodansky, Andrew F Kung, Zoe Quandt, Elise MN Ferré, Nils Landegren, Daniel Eriksson, Paul Bastard, Shen-Ying Zhang, Jamin Liu, Anthea Mitchell, Irina Proekt, David Yu, Caleigh Mandel-Brehm, Chung-Yu Wang, Brenda Miao, Gavin Sowa, Kelsey Zorn, Alice Y Chan, Veronica M Tagi, Chisato Shimizu, Adriana Tremoulet, Kara Lynch, Michael R Wilson, Olle Kämpe, Kerry Dobbs, Ottavia M Delmonte, Rosa Bacchetta, Luigi D Notarangelo, Jane C Burns, Jean-Laurent Casanova, Michail S Lionakis, Troy R Torgerson, Mark S Anderson, Joseph L DeRisi
Publikováno v:
eLife, Vol 11 (2022)
Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understo
Externí odkaz:
https://doaj.org/article/fc84c5436a6d424088e17402a161e72b
Autor:
Alice S. Chau, Bonnie L. Cole, Jason S. Debley, Kabita Nanda, Aaron B. I. Rosen, Michael J. Bamshad, Deborah A. Nickerson, Troy R. Torgerson, Eric J. Allenspach
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 18, Iss 1, Pp 1-9 (2020)
Abstract Background Heme oxygenase-1 (HMOX1) catalyzes the metabolism of heme into carbon monoxide, ferrous iron, and biliverdin. Through biliverdin reductase, biliverdin becomes bilirubin. HMOX1-deficiency is a rare autosomal recessive disorder with
Externí odkaz:
https://doaj.org/article/a9dddf2d6b2440e3adddb7c6d95d90b8
Autor:
Palak C. Genge, Charles R. Roll, Alexander T. Heubeck, Elliott Swanson, Nina Kondza, Cara Lord, Morgan Weiss, Veronica Hernandez, Cole Phalen, Zachary Thomson, Troy R. Torgerson, Peter J. Skene, Thomas F. Bumol, Julian Reading
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100900- (2021)
Summary: Deep immune profiling is essential for understanding the human immune system in health and disease. Successful biological interpretation of this data requires consistent laboratory processing with minimal batch-to-batch variation. Here, we d
Externí odkaz:
https://doaj.org/article/fae212fe174d4a2a85ae33c7cb9322d0
Autor:
Adam K. Savage, Miriam V. Gutschow, Tony Chiang, Kathy Henderson, Richard Green, Monica Chaudhari, Elliott Swanson, Alexander T. Heubeck, Nina Kondza, Kelli C. Burley, Palak C. Genge, Cara Lord, Tanja Smith, Zachary Thomson, Aldan Beaubien, Ed Johnson, Jeff Goldy, Hamid Bolouri, Jane H. Buckner, Paul Meijer, Ernest M. Coffey, Peter J. Skene, Troy R. Torgerson, Xiao-jun Li, Thomas F. Bumol
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102404- (2021)
Summary: Multi-omic profiling of human peripheral blood is increasingly utilized to identify biomarkers and pathophysiologic mechanisms of disease. The importance of these platforms in clinical and translational studies led us to investigate the impa
Externí odkaz:
https://doaj.org/article/a1e55c9d0af740fea6a687681949f26b
Autor:
Elliott Swanson, Cara Lord, Julian Reading, Alexander T Heubeck, Palak C Genge, Zachary Thomson, Morgan DA Weiss, Xiao-jun Li, Adam K Savage, Richard R Green, Troy R Torgerson, Thomas F Bumol, Lucas T Graybuck, Peter J Skene
Publikováno v:
eLife, Vol 10 (2021)
Single-cell measurements of cellular characteristics have been instrumental in understanding the heterogeneous pathways that drive differentiation, cellular responses to signals, and human disease. Recent advances have allowed paired capture of prote
Externí odkaz:
https://doaj.org/article/046189b6ef98402f806f13d5a7619de7