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Akademický článek

Strategies to Overcome Failures in T-Cell Immunotherapies by Targeting PI3K-δ and –γ

Autor: Sanjay Chandrasekaran, Christopher Ronald Funk, Troy Kleber, Chrystal M. Paulos, Mala Shanmugam, Edmund K. Waller

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

PI3K-δ and PI3K-γ are critical regulators of T-cell differentiation, senescence, and metabolism. PI3K-δ and PI3K-γ signaling can contribute to T-cell inhibition via intrinsic mechanisms and regulation of suppressor cell populations, including reg

Externí odkaz: https://doaj.org/article/92be64c2bfd64173a0da04ef9adb7601

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Whole-lung low-dose radiation therapy (LD-RT) for non-intubated oxygen-dependent patients with COVID-19-related pneumonia receiving dexamethasone and/or remdesevir

Autor: Brent D. Weinberg, Rafi Ahmed, Alvaro Perez Daisson, Soumon Rudra, Troy Kleber, Jeffrey M. Switchenko, Clayton B. Hess, Tony Y. Eng, Tahseen H. Nasti, Mohammad K. Khan, Vishal R. Dhere, Nadine Rouphael, Sibo Tian, Luisa S. Taverna

Publikováno v: Radiotherapy and Oncology

BACKGROUND: Low-dose radiotherapy (LD-RT) has produced anti-inflammatory effects in both animal models and early human trials of COVID-19-related pneumonia. The role of whole-lung LD-RT within existing treatment paradigms merits further study. METHOD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f08e534f48ef3b597e8b29da826652b
https://pubmed.ncbi.nlm.nih.gov/35065144

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Effect of immunotherapy time-of-day infusion on overall survival among patients with advanced melanoma in the USA (MEMOIR): a propensity score-matched analysis of a single-centre, longitudinal study

Autor: Melinda L. Yushak, Jim Zhong, David H. Lawson, David C. Qian, Brianna Brammer, Chrystal M. Paulos, Mohammad K. Khan, James Janopaul-Naylor, Troy Kleber, Jeffrey M. Switchenko, R. Donald Harvey, Karen M. Xu, Zachary S. Buchwald, Ragini R. Kudchadkar

Publikováno v: The Lancet. Oncology. 22(12)

Summary Background The dependence of the adaptive immune system on circadian rhythm is an emerging field of study with potential therapeutic implications. We aimed to determine whether specific time-of-day patterns of immune checkpoint inhibitor infu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2aa58804aa58530e8af7c7c37c8591
https://pubmed.ncbi.nlm.nih.gov/35266675

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Reduced Intubation Rates Following Whole-Lung Low-Dose Radiation Therapy (LD-RT) in Patients With COVID-19-Related Pneumonia

Autor: Tony Y. Eng, Vishal R. Dhere, Mostofa K. Khan, Soumon Rudra, L.S. Taverna, Tahseen H. Nasti, A. Perez, Brent D. Weinberg, Troy Kleber, Sibo Tian, Clayton B. Hess, Nadine Rouphael, Rafi Ahmed, Jeffrey M. Switchenko

Publikováno v: International Journal of Radiation Oncology, Biology, Physics

Purpose/Objective(s) Low-dose radiotherapy (LD-RT) is a well-established treatment for multiple human inflammatory conditions. Whole-lung LD-RT may be effective in COVID-19-related pneumonia. Materials/Methods Patients hospitalized with COVID-19-rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d64553441e5a0cb1ca29c471304a8ef
http://europepmc.org/articles/PMC8536245

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Response to Whole-Lung Low-Dose Radiation Therapy (LD-RT) Predicts Freedom from Intubation in Patients Receiving Dexamethasone and/or Remdesevir for COVID-19-Related Acute Respiratory Distress Syndrome (ARDS)

Autor: L.S. Taverna, Vishal R. Dhere, Rafi Ahmed, J. Switchenko, Tony Y. Eng, Soumon Rudra, Mostofa K. Khan, Tahseen H. Nasti, A. Perez, Sibo Tian, Brent D. Weinberg, Troy Kleber, Nadine Rouphael, Clayton B. Hess

BackgroundPhase I/II clinical trials have explored whole-lung low-dose radiotherapy (LD-RT) as a potential treatment for patients with COVID-19-related acute respiratory distress syndrome (ARDS). Initial findings require reproduction. Concomitant LD-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::295454c6beb5693166f85447f2aef1e3
https://doi.org/10.1101/2021.02.10.21251242

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Single Institutional Outcomes of Whole Brain Radiotherapy for Metastatic Melanoma Brain Metastases

Autor: Troy Kleber, Mohammad K. Khan, Jeffrey M. Switchenko, Cecilia Jiang

Publikováno v: Radiation Oncology, Vol 16, Iss 1, Pp 1-11 (2021)
Radiation Oncology (London, England)

Background The management of melanoma with brain metastases (MBM) is increasingly complex, especially given recent improvements in targeted agents, immunotherapy, and radiotherapy. Whole brain radiation therapy (WBRT) is a longstanding radiotherapy t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d2c07b8f5568382f78a0bd03d91826
https://doi.org/10.21203/rs.3.rs-89350/v1

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Immunomodulatory Low-Dose Whole-Lung Radiation for Patients with Coronavirus Disease 2019-Related Pneumonia

Autor: Brent D. Weinberg, David J. Murphy, Troy Kleber, Rafi Ahmed, Walter J. Curran, Jeffrey M. Switchenko, Karen D. Godette, James P. Steinberg, Tahseen H. Nasti, Clayton B. Hess, William A. Stokes, Nadine Rouphael, Vishal R. Dhere, Zachary S. Buchwald, Mohammad K. Khan

Publikováno v: International Journal of Radiation Oncology, Biology, Physics
International Journal of Radiation Oncology*Biology*Physics

Purpose Phase 1 clinical trials have established low-dose, whole-lung radiation therapy (LD-RT) as safe for patients with coronavirus disease 2019 (COVID-19)-related pneumonia. By focally dampening cytokine hyperactivation, LD-RT may improve disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b9528a1499d68f9f89bb4bc62ddc8c
https://pubmed.ncbi.nlm.nih.gov/33340603

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Phase 1, 2 trial of concurrent anti-PD1 and stereotactic radiosurgery for melanoma and non-small cell lung cancer brain metastases (NCT02858869)

Autor: David H. Lawson, Troy Kleber, David G. Wallington, Taofeek K. Owonikoko, Tahseen H. Nasti, Suresh S. Ramalingam, Rafi Ahmed, Mohammad K. Khan, Jeffrey M. Switchenko, Melinda L. Yushak, Khadija Kirmani

Publikováno v: Journal of Clinical Oncology. 39:2022-2022

2022 Background: The safety and efficacy of concurrent pembrolizumab (anti-PD1) and stereotactic radiosurgery (SRS) for brain metastases (BM) is unknown. Methods: Patients with melanoma or NSCLC, 1-10 brain metastases, ≥ 1 extra-cranial lesion, age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97ea411aedcb929ab44be81614253e5a
https://doi.org/10.1200/jco.2021.39.15_suppl.2022

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Interim results of prospective pilot phase II trial of concurrent anti-PD-1 and stereotactic radiosurgery (SRS) for melanoma and NSCLC patients with brain metastases (NCT02858869)

Autor: Mohammad K. Khan, Troy Kleber, Melinda L. Yushak, David H. Lawson, Taofeek K. Owonikoko, Rafi Ahmed, Jeffrey M. Switchenko, Suresh Ramalingam, David G. Wallington, Khadija Kirmani, Tahseen H. Nasti

Publikováno v: Journal of Clinical Oncology. 38:e22002-e22002

e22002 Background: The safety and efficacy of concurrent radiotherapy (SRS) and single agent (anti-PD-1) checkpoint inhibitor have not been established. We report the first results of an interim analysis from a prospective pilot phase II trial of coc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::811e4737392f6232799444069412f4b3
https://doi.org/10.1200/jco.2020.38.15_suppl.e22002

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