Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Troy Dumenil"'
Autor:
Romal Stewart, Kexin Yan, Sevannah A. Ellis, Cameron R. Bishop, Troy Dumenil, Bing Tang, Wilson Nguyen, Thibaut Larcher, Rhys Parry, Julian De Jun Sng, Alexander A. Khromykh, Robert K. P. Sullivan, Mary Lor, Frédéric A. Meunier, Daniel J. Rawle, Andreas Suhrbier
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
The reduced pathogenicity of the omicron BA.1 sub-lineage compared to earlier variants is well described, although whether such attenuation is retained for later variants like BA.5 and XBB remains controversial. We show that BA.5 and XBB isolates wer
Externí odkaz:
https://doaj.org/article/e3bb846c283046a5ad1923ef2b19de68
Autor:
Cameron R Bishop, Troy Dumenil, Daniel J Rawle, Thuy T Le, Kexin Yan, Bing Tang, Gunter Hartel, Andreas Suhrbier
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010867 (2022)
How well mouse models recapitulate the transcriptional profiles seen in humans remains debatable, with both conservation and diversity identified in various settings. Herein we use RNA-Seq data and bioinformatics approaches to analyze the transcripti
Externí odkaz:
https://doaj.org/article/a1b4187f3c6b4ab09dc55588b8b10abd
Autor:
Daniel J Rawle, Thuy T Le, Troy Dumenil, Cameron Bishop, Kexin Yan, Eri Nakayama, Phillip I Bird, Andreas Suhrbier
Publikováno v:
eLife, Vol 11 (2022)
Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma-/- mouse studies having informed our understanding of GZMA’s physiological function. We show herein that Gzma-/- mice have a mixed C57BL/6J and C57BL/6N genetic bac
Externí odkaz:
https://doaj.org/article/52beee401a264cc08b6f6799d457738e
Autor:
Lochlan Fennell, Troy Dumenil, Leesa Wockner, Gunter Hartel, Katia Nones, Catherine Bond, Jennifer Borowsky, Cheng Liu, Diane McKeone, Lisa Bowdler, Grant Montgomery, Kerenaftali Klein, Isabell Hoffmann, Ann-Marie Patch, Stephen Kazakoff, John Pearson, Nicola Waddell, Pratyaksha Wirapati, Paul Lochhead, Yu Imamura, Shuji Ogino, Renfu Shao, Sabine Tejpar, Barbara Leggett, Vicki Whitehall
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 2, Pp 269-290 (2019)
Background & Aims: Colorectal cancer is an epigenetically heterogeneous disease, however, the extent and spectrum of the CpG island methylator phenotype (CIMP) is not clear. Methods: Genome-scale methylation and transcript expression were measured by
Externí odkaz:
https://doaj.org/article/896d8d83832d45a6a844a6f3efd1b27a
Autor:
Jessamine E Hazlewood, Troy Dumenil, Thuy T Le, Andrii Slonchak, Stephen H Kazakoff, Ann-Marie Patch, Lesley-Ann Gray, Paul M Howley, Liang Liu, John D Hayball, Kexin Yan, Daniel J Rawle, Natalie A Prow, Andreas Suhrbier
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009215 (2021)
Poxvirus systems have been extensively used as vaccine vectors. Herein a RNA-Seq analysis of intramuscular injection sites provided detailed insights into host innate immune responses, as well as expression of vector and recombinant immunogen genes,
Externí odkaz:
https://doaj.org/article/51873aa015164c15b3f0332db477b26b
Autor:
Bryony A. Thompson, Rhiannon Walters, Michael T. Parsons, Troy Dumenil, Mark Drost, Yvonne Tiersma, Noralane M. Lindor, Sean V. Tavtigian, Niels de Wind, Amanda B. Spurdle, the InSiGHT Variant Interpretation Committee, Fahd Al-Mulla, Daniel Buchanan, Susan Farrington, Ian Frayling, Maurizio Genuardi, Elke Holinski-Feder, Maija R. J. Kohonen-Corish, Andreas Laner, Alexandra Martins, Finlay Macrae, Pål Møller, Monika Morak, Elisabet Ognedal, John-Paul Plazzer, Lene Juel Rasmussen, Carli Tops
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Functional assays that assess mRNA splicing can be used in interpretation of the clinical significance of sequence variants, including the Lynch syndrome-associated mismatch repair (MMR) genes. The purpose of this study was to investigate the contrib
Externí odkaz:
https://doaj.org/article/9cc3036b8517473a900b9588e8069c13
Autor:
Catherine E. Bond, Cheng Liu, Futoshi Kawamata, Diane M. McKeone, Winnie Fernando, Saara Jamieson, Sally-Ann Pearson, Alexandra Kane, Susan L. Woods, Tamsin R. M. Lannagan, Roshini Somashekar, Young Lee, Troy Dumenil, Gunter Hartel, Kevin J. Spring, Jennifer Borowsky, Lochlan Fennell, Mark Bettington, Jason Lee, Daniel L. Worthley, Barbara A. Leggett, Vicki L. J. Whitehall
Publikováno v:
Epigenetics, Vol 13, Iss 1, Pp 40-48 (2018)
Colorectal cancer is a major cause of cancer death and approximately 20% arises within serrated polyps, which are under-recognized and poorly understood. Human serrated colorectal polyps frequently exhibit both oncogenic BRAF mutation and widespread
Externí odkaz:
https://doaj.org/article/a0eb35f1f5c1498b9b8dd60644c1c526
Autor:
Daniel J. Rawle, Wilson Nguyen, Troy Dumenil, Rhys Parry, David Warrilow, Bing Tang, Thuy T. Le, Andrii Slonchak, Alexander A. Khromykh, Viviana P. Lutzky, Kexin Yan, Andreas Suhrbier
Publikováno v:
Pathogens, Vol 9, Iss 10, p 848 (2020)
Getah virus (GETV) is a mosquito-transmitted alphavirus primarily associated with disease in horses and pigs in Asia. GETV was also reported to have been isolated from mosquitoes in Australia in 1961; however, retrieval and sequencing of the original
Externí odkaz:
https://doaj.org/article/9f535f6c52dc484190ea3356d535731e
Autor:
Lochlan J. Fennell, Alexandra Kane, Cheng Liu, Diane McKeone, Winnie Fernando, Chang Su, Catherine Bond, Saara Jamieson, Troy Dumenil, Ann-Marie Patch, Stephen H. Kazakoff, John V. Pearson, Nicola Waddell, Barbara Leggett, Vicki L. J. Whitehall
Publikováno v:
Cancers, Vol 12, Iss 5, p 1171 (2020)
Background: WNT activation is a hallmark of colorectal cancer. BRAF mutation is present in 15% of colorectal cancers, and the role of mutations in WNT signaling regulators in this context is unclear. Here, we evaluate the mutational landscape of WNT
Externí odkaz:
https://doaj.org/article/5cff4ce571d5417ba20c679bc7889c46
Autor:
Romal Stewart, Sevannah Ellis, Kexin Yan, Troy Dumenil, Cameron Bishop, Bing Tang, Wilson Nguyen, Thibaut Larcher, Robert Sullivan, Mary Lor, Frederic Meunier, Daniel Rawle, Andreas Suhrbier
The reduced pathogenicity of the omicron BA.1 sub-lineage compared to earlier variants is well described, although whether such attenuation is retained for later variants like BA.5 remains controversial. We show that a BA.5 isolate was significantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8925c0fdedd0359bfee298fa88a51b47
https://doi.org/10.21203/rs.3.rs-2702556/v1
https://doi.org/10.21203/rs.3.rs-2702556/v1