Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Troy A. A. Harkness"'
Autor:
Carla Almendáriz-Palacios, Zoe E. Gillespie, Matthew Janzen, Valeria Martinez, Joanna M. Bridger, Troy A. A. Harkness, Darrell D. Mousseau, Christopher H. Eskiw
Publikováno v:
Biomedicines, Vol 8, Iss 7, p 188 (2020)
Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging.
Externí odkaz:
https://doaj.org/article/dabe5c2be942465da22e52566196e34a
Autor:
Troy A. A. Harkness
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1888 (2018)
In aging cells, genomic instability is now recognized as a hallmark event. Throughout life, cells encounter multiple endogenous and exogenous DNA damaging events that are mostly repaired, but inevitably DNA mutations, chromosome rearrangements, and e
Externí odkaz:
https://doaj.org/article/2bd3148ef25943aa98f06daff2396889
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
Externí odkaz:
https://doaj.org/article/81a424f15abf4df485247264426c3b9c
Autor:
Terra G. Arnason, Valerie MacDonald-Dickinson, Matthew Casey Gaunt, Gerald F. Davies, Liubov Lobanova, Brett Trost, Zoe E. Gillespie, Matthew Waldner, Paige Baldwin, Devon Borrowman, Hailey Marwood, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Christopher H. Eskiw, Anthony Kusalik, Troy A. A. Harkness
Publikováno v:
Cancers; Volume 14; Issue 17; Pages: 4215
Like humans, canine lymphomas are treated by chemotherapy cocktails and frequently develop multiple drug resistance (MDR). Their shortened clinical timelines and tumor accessibility make canines excellent models to study MDR mechanisms. Insulin-sensi
Publikováno v:
Aging (Albany NY)
The Anaphase Promoting Complex (APC), a multi-subunit ubiquitin ligase, facilitates mitotic and G1 progression, and is now recognized to play a role in maintaining genomic stability. Many APC substrates have been observed overexpressed in multiple ca
Autor:
Rachel E. Harris, Troy A. A. Harkness
Publikováno v:
Cancer Research. 83:B024-B024
The Anaphase Promoting Complex (APC), a large and highly conserved ubiquitin ligase, is involved in genome stability, resistance to cancer progression, and has an important role in promoting health and lifespan. While best known for its function duri
Publikováno v:
Aging Cell
The ribosomal DNA (rDNA) in Saccharomyces cerevisiae is in one tandem repeat array on Chromosome XII. Two regions within each repetitive element, called intergenic spacer 1 (IGS1) and IGS2, are important for organizing the rDNA within the nucleolus.
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608678
The budding yeast is a valuable model system for discovering molecular mechanisms underlying cellular aging. This is due to the ease of performing genetic manipulations in yeast and the vast number of evolutionarily conserved genes that have been fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b5104e73ec8ecae89b34c73680670fc
https://doi.org/10.1007/978-1-0716-0868-5_18
https://doi.org/10.1007/978-1-0716-0868-5_18
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2196
The budding yeast is a valuable model system for discovering molecular mechanisms underlying cellular aging. This is due to the ease of performing genetic manipulations in yeast and the vast number of evolutionarily conserved genes that have been fou
Autor:
Troy A. A. Harkness, Joanna M. Bridger, Zoe E. Gillespie, Christopher H. Eskiw, Valeria Martinez, Carla Almendáriz-Palacios, Matthew Janzen, Darrell D. Mousseau
Publikováno v:
Biomedicines
Biomedicines, Vol 8, Iss 188, p 188 (2020)
Biomedicines, Vol 8, Iss 188, p 188 (2020)
Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging.