An Original and Efficient Antibiotic Adjuvant Strategy to Enhance the Activity of Macrolide Antibiotics against Gram-Negative Resistant Strains.

Autor: Troudi, Azza^1,2 (AUTHOR), Bolla, Jean Michel¹ (AUTHOR), Klibi, Naouel² (AUTHOR), Brunel, Jean Michel¹ (AUTHOR) jean-michel.brunel@inserm.fr

Publikováno v: International Journal of Molecular Sciences. Oct2022, Vol. 23 Issue 20, p12457-N.PAG. 14p.

Novel sulfonamide-β-lactam hybrids incorporating the piperazine moiety as potential iNOS inhibitors with promising antibacterial activity

Autor: Heiran, Roghayeh, Jarrahpour, Aliasghar, Riazimontazer, Elham, Gholami, Ahmad, Troudi, Azza, Di Giorgio, Carole, Michel Brunel, Jean, Turos, Edward

Publikováno v: ChemistrySelect
ChemistrySelect, 2021, 6 (21), pp.5313-5319. ⟨10.1002/slct.202101194⟩
ChemistrySelect, Wiley, 2021, 6 (21), pp.5313-5319. ⟨10.1002/slct.202101194⟩

International audience; Supporting information for this article is given via a link at the end of the document.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7e5e03c909af351dfe9eb05d2e6296a7
https://hal.science/hal-03368290/document

Chemical highlight supporting the Lipid A role in efficient biological adaptation of Gram-negative bacteria face to external stresses

Autor: Troudi, Azza, Pagès, Jean Marie, Brunel, Jean Michel

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (4), pp.1816-1834. ⟨10.1021/acs.jmedchem.0c02185⟩
Journal of Medicinal Chemistry, 2021, 64 (4), pp.1816-1834. ⟨10.1021/acs.jmedchem.0c02185⟩

International audience; The outer membrane (OM) of Gram-negative bacteria provides an efficient barrier against external noxious compounds such as antimicrobial agents. Associated with drug target modification it contributes to the overall failure of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::15e8a4746907ff501aca900ff5a04a85
https://doi.org/10.1021/acs.jmedchem.0c02185

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Sulfonamide‐β‐lactam Hybrids Incorporating the Piperazine Moiety as Potential Antiinflammatory Agent with Promising Antibacterial Activity.

Autor: Heiran, Roghayeh, Jarrahpour, Aliasghar, Riazimontazer, Elham, Gholami, Ahmad, Troudi, Azza, Digiorgio, Carole, Brunel, Jean Michel, Turos, Edward

Publikováno v: ChemistrySelect; 6/8/2021, Vol. 6 Issue 21, p5313-5319, 7p