Elevated basal AMP-activated protein kinase activity sensitizes colorectal cancer cells to growth inhibition by metformin.

Autor: Morrison KR; Flinders Health and Medical Research Institute, Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, SA 5042, Australia., Wang T; Flinders Health and Medical Research Institute, Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, SA 5042, Australia., Chan KY; Cancer Research UK Manchester Institute, Alderley Park, Macclesfield SK10 4TG, UK., Trotter EW; Cancer Research UK Manchester Institute, Alderley Park, Macclesfield SK10 4TG, UK., Gillespie A; Flinders Health and Medical Research Institute, Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, SA 5042, Australia., Michael MZ; Flinders Health and Medical Research Institute, Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, SA 5042, Australia.; Flinders Centre for Innovation in Cancer, Dept. Gastroenterology and Hepatology, Flinders Medical Centre, Bedford Park, SA 5042, Australia., Oakhill JS; Metabolic Signalling Laboratory, St Vincent's Institute of Medical Research, School of Medicine, University of Melbourne, Victoria 3065, Australia.; Mary MacKillop Institute for Health Research, Australian Catholic University, Victoria 3000, Australia., Hagan IM; Cancer Research UK Manchester Institute, Alderley Park, Macclesfield SK10 4TG, UK., Petersen J; Flinders Health and Medical Research Institute, Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, SA 5042, Australia.; Nutrition and Metabolism, South Australia Health and Medical Research Institute, Adelaide, SA 5000, Australia.

Publikováno v: Open biology [Open Biol] 2023 Apr; Vol. 13 (4), pp. 230021. Date of Electronic Publication: 2023 Apr 12.

Exploiting phenotypic heterogeneity to improve production of glutathione by yeast.

Autor: Xu, Mingzhi¹ (AUTHOR), Vallières, Cindy¹ (AUTHOR), Finnis, Chris² (AUTHOR), Winzer, Klaus¹ (AUTHOR), Avery, Simon V.¹ (AUTHOR) Simon.Avery@nottingham.ac.uk

Publikováno v: Microbial Cell Factories. 10/7/2024, Vol. 23 Issue 1, p1-12. 12p.

Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor

Autor: Antal, CE, Hudson, AM, Kang, E, Zanca, C, Wirth, C, Stephenson, NL, Trotter, EW, Gallegos, LL, Miller, CJ, Furnari, FB, Hunter, T, Brognard, J, Newton, AC

Publikováno v: Antal, CE; Hudson, AM; Kang, E; Zanca, C; Wirth, C; Stephenson, NL; et al.(2015). Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor. Cell, 160(3), 489-502. doi: 10.1016/j.cell.2015.01.001. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/5903j9zb

© 2015 Elsevier Inc.Protein kinase C (PKC) isozymes have remained elusive cancer targets despite the unambiguous tumor promoting function of their potent ligands, phorbol esters, and the prevalence of their mutations. We analyzed 8% of PKC mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::3d908200df73f2a9f11a55b6aae0502c
http://www.escholarship.org/uc/item/5903j9zb

Systems analysis of transcription factor activities in environments with stable and dynamic oxygen concentrations

Autor: Rolfe, MD, Ocone, A, Stapleton, MR, Hall, S, Trotter, EW, Poole, RK, Sanguinetti, G, Green, J, SysMO-SUMO consortium

Publikováno v: Open Biology, 2(7), 120091. (2012).

Understanding gene regulation requires knowledge of changes in transcription factor (TF) activities. Simultaneous direct measurement of numerous TF activities is currently impossible. Nevertheless, statistical approaches to infer TF activities have y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2658::ff19c41e01181739b93866c972caaf94
http://orbilu.uni.lu/handle/10993/4546

Immunologists’ Perspectives on Monogenic Inflammatory Bowel Diseases.

Autor: Ali Osman, Maryiam Jama^1,2, Aydoğdu, Emine Selva³, Mackeh, Rafah², Özen, Ahmet^4,5,6, Lo, Bernice^1,2 blo@sidra.org

Publikováno v: Turkish Journal of Immunology. 2024 Suppl 1, Vol. 12, p17-36. 20p.