Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity.

Autor: Pigoni M; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Uzquiano A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Paulsen B; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kedaigle AJ; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Yang SM; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Symvoulidis P; McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA., Adiconis X; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Velasco S; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Sartore R; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kim K; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Tucewicz A; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Tropp SY; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Tsafou K; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jin X; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Society of Fellows, Harvard University, Cambridge, MA 02138, USA., Barrett L; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Chen F; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Boyden ES; McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; MIT Center for Neurobiological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Harvard-MIT Health Sciences & Technology Program (HST), Harvard Medical School, Boston, MA 02115, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, MIT, Cambridge, MA 02138, USA.; Department of Brain of Cognitive Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Department of Media Arts and Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Levin JZ; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Arlotta P; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2023 Sep 05; Vol. 32 (18), pp. 2773-2786.