Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Troponin T binding"'
Autor:
Simona Scarano, Pasquale Palladino, Alvaro Brittoli, Maria Minunni, Veronica Baldoneschi, Francesca Torrini
Publikováno v:
Analytical and bioanalytical chemistry. 411(29)
Early diagnosis of acute myocardial infarction (AMI) is of outmost importance to reduce the mortality rate, and cardiac troponins are considered the gold standard biomarkers of myocardial necrosis. In this scenario, the characterization of two tropon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187a4c18cfa4f8b2bcc51c0008109624
https://pubmed.ncbi.nlm.nih.gov/31300860
https://pubmed.ncbi.nlm.nih.gov/31300860
Autor:
Galina V. Kopylova, Alexander M. Matyushenko, Anastasia V. Pivovarova, Katerina E. Popruga, Sergey Y. Bershitsky, Dmitrii I. Levitsky, Natalya V. Artemova, D. V. Shchepkin
Publikováno v:
Biochemistry. 56(1)
Hypertrophic cardiomyopathy (HCM) is a severe heart disease caused by missense mutations in genes encoding sarcomeric proteins of cardiac muscle. Many of these mutations are identified in the gene encoding the cardiac isoform of tropomyosin (Tpm), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cf507ab8a124463544896919915f91
https://pubmed.ncbi.nlm.nih.gov/27983818
https://pubmed.ncbi.nlm.nih.gov/27983818
Publikováno v:
Journal of Molecular and Cellular Cardiology. 48:893-898
Tropomyosin plays a key role in controlling calcium regulated sarcomeric contraction through its interactions with actin and the troponin complex. The focus of this review is on striated muscle tropomyosin isoforms and the in vivo approach we have ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536ab6ed1029e4a4416560057fb7ea70
https://doi.org/10.1016/j.yjmcc.2009.10.003
https://doi.org/10.1016/j.yjmcc.2009.10.003
Publikováno v:
European Journal of Biochemistry. 271:4132-4140
Mutations in the protein alpha-tropomyosin (Tm) can cause a disease known as familial hypertrophic cardiomyopathy. In order to understand how such mutations lead to protein dysfunction, three point mutations were introduced into cDNA encoding the hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c1508ae6b58ce928d8a4ab9e9d70dc0
https://doi.org/10.1111/j.1432-1033.2004.04351.x
https://doi.org/10.1111/j.1432-1033.2004.04351.x
Autor:
Greg P. Boivin, Arnold Schwartz, Susan Vahebi, David F. Wieczorek, R. John Solaro, Ganapathy Jagatheesan, Sudarsan Rajan, Pieter deTombe, Erin Labitzke, George M. Hilliard, Natalia Petrashevskaya
Publikováno v:
Journal of Biological Chemistry. 278:23204-23211
Striated muscle tropomyosin (TM) interacts with actin and the troponin complex to regulate calcium-mediated muscle contraction. Previous work by our laboratory established that alpha- and beta-TM isoforms elicit physiological differences in sarcomeri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aceb27d32af611cd1ff8e06096a5a2f
https://doi.org/10.1074/jbc.m303073200
https://doi.org/10.1074/jbc.m303073200
Autor:
Bruce J. Aronow, Arnold Schwartz, Rethinasamy Prabhakar, Natalia Petrashevskaya, Jeffery D. Molkentin, Greg P. Boivin, David F. Wieczorek
Publikováno v:
Molecular and Cellular Biochemistry. 251:33-42
Familial hypertrophic cardiomyopathy, a disease caused by mutations in cardiac contractile proteins, is characterized by left and/or right ventricular hypertrophy, myocyte disarray, fibrosis, and cardiac arrhythmias that may lead to premature sudden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d9206c9d87b89e6fc54724703e4e525
https://doi.org/10.1023/a:1025409227350
https://doi.org/10.1023/a:1025409227350
Autor:
Christian C. Evans, Brian D. Hoit, Greg P. Boivin, R. John Solaro, Beata M. Wolska, David F. Wieczorek, Kathy Pieples, Prabhakar Rethinasamy, Ingrid L. Grupp, Mariappan Muthuchamy
Publikováno v:
Circulation Research. 85:47-56
Abstract —To investigate the functional consequences of a tropomyosin (TM) mutation associated with familial hypertrophic cardiomyopathy (FHC), we generated transgenic mice that express mutant α-TM in the adult heart. The missense mutation, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da301fe44ed0fc35b34c8ab9419a510
https://doi.org/10.1161/01.res.85.1.47
https://doi.org/10.1161/01.res.85.1.47
Publikováno v:
Biophysical Journal. 104(2)
Association of the regulatory N-domain of cardiac troponin C (cNTnC) with the switch region of cardiac troponin I (cTnI147-163) is a major step in Ca2+ regulation of myocardial contraction by troponin as it triggers a series of downstream events that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0d6ffde134cd40f76f6d42b77a59dc
Publikováno v:
Biochemistry. 34:11872-11881
We have studied the properties of rabbit skeletal troponin C (TnC) fully acetylated at its lysine residues (AcTnC). Acetylation causes a decrease in thermal stability of both domains of TnC in the absence of Ca2+. At 25 degrees C, the acetylated C-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416abbf40c1b8128dab8978b6f7d02de
https://doi.org/10.1021/bi00037a027
https://doi.org/10.1021/bi00037a027
Autor:
J.F. Kuo, T A Noland
Publikováno v:
Biochemical Journal. 288:123-129
Effects of phosphorylation of bovine cardiac troponin T (TnT) by protein kinase C on the Ca(2+)-stimulated MgATPase activity of reconstituted actomyosin complex and the binding of TnT to tropomyosin(Tm)-F-actin were investigated. The Ca(2+)-stimulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a2863d4b9f6530954ceb675684287f
https://doi.org/10.1042/bj2880123
https://doi.org/10.1042/bj2880123