Zobrazeno 1 - 10
of 9 519
pro vyhledávání: '"Tropomyosin receptor kinase A"'
Publikováno v:
Journal of Pain Research, Vol Volume 17, Pp 3919-3932 (2024)
Yeeun Kim,1,2,* Min-A Je,1,2,* Myeongguk Jeong,1,2 Hyeokjin Kwon,1,2 Aelee Jang,3 Jungho Kim,1,2 Go-Eun Choi1,2 1Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan, 46252, Republic of Ko
Externí odkaz:
https://doaj.org/article/8dca9e31faa64faf9eda5d0083b61e3c
Autor:
M. Svrcek, A. Cayre, T. Samaille, R. Colle, L. Mas, P. Bourgoin, E. Guillerm, R. Cohen, F. Penault-Llorca, T. André, N. Radosevic-Robin
Publikováno v:
ESMO Gastrointestinal Oncology, Vol 5, Iss , Pp 100084- (2024)
Background: Currently, mismatch repair deficient/microsatellite instable (dMMR/MSI) status constitutes a validated predictive marker of response to immune checkpoint inhibitors (ICIs) in patients with metastatic colorectal cancer (mCRC). Unfortunatel
Externí odkaz:
https://doaj.org/article/c13e226ef8ae42d482ef71c5b131358b
Publikováno v:
Cancer Medicine, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract Background Members of the neurotrophic tropomyosin receptor kinase (NTRK) gene family, NTRK1, NTRK2, and NTRK3 encode TRK receptor tyrosine kinases. Intra‐ or inter‐chromosomal gene rearrangements produce NTRK gene fusions encoding fusio
Externí odkaz:
https://doaj.org/article/0c4e6c216d3d4e609290f7e2ce658c5f
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 26, Iss 6, Pp 701-707 (2023)
Objective(s): To investigate the potential of Tropomyosin receptor kinase A (TrkA) for the treatment of interstitial cystitis/ bladder pain syndrome (IC/BPS).Materials and Methods: Sixty-four female rats were randomly assigned to the control and cycl
Externí odkaz:
https://doaj.org/article/7d805ea219fa475db4809cfc6ffd2d1b
Autor:
Audrey Roussel-Gervais, Stéphanie Sgroi, Yves Cambet, Sylvain Lemeille, Tamara Seredenina, Karl-Heinz Krause, Vincent Jaquet
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The tropomyosin receptor kinase B (TrkB) is encoded by the NTRK2 gene. It belongs to the family of transmembrane tyrosine kinases, which have key roles in the development and maintenance of the nervous system. Brain-derived neurotrophic factor (BDNF)
Externí odkaz:
https://doaj.org/article/5490a6c7719248d6b37acd6f28691abb
Autor:
Raquel Comaposada-Baró, Andrea Benito-Martínez, Juan Julian Escribano-Saiz, María Luisa Franco, Lorenzo Ceccarelli, Isabel Calatayud-Baselga, Helena Mira, Marçal Vilar
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Degeneration of basal forebrain cholinergic neurons (BFCNs) is a hallmark of Alzheimer’s disease (AD). However, few mouse models of AD recapitulate the neurodegeneration of the cholinergic system. The p75 neurotrophin receptor, p75NTR, has been ass
Externí odkaz:
https://doaj.org/article/b32bcd3bb77444a1a7f76966aae5d7b9
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 6, Pp 1220-1228 (2023)
Aging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading to cognitive decline. This process represents the major risk factor for aging-related diseases such as Alzheimer’s disease, Parkinson’
Externí odkaz:
https://doaj.org/article/4b61785e40e249cd81266dc21d7773e4
Autor:
Mohd Aizuddin Mohd Lazaldin, Igor Iezhitsa, Renu Agarwal, Puneet Agarwal, Nafeeza Mohd Ismail
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 2, Pp 382-388 (2023)
Amyloid-beta (Aβ)-related alterations, similar to those found in the brains of patients with Alzheimer’s disease, have been observed in the retina of patients with glaucoma. Decreased levels of brain-derived neurotrophic factor (BDNF) are believed
Externí odkaz:
https://doaj.org/article/05accb6a252b47c88caec6c5aaac9be8
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
AimsHuntingtin-associated protein 1 (HAP1) is a neuronal protein closely associated with microtubules and might facilitate neurological function rehabilitation. This study aimed to investigate the effects of HAP1 on SCI and the underlying mechanisms.
Externí odkaz:
https://doaj.org/article/20e96e50cbe1460d90d0d0e10ae5ac53
Autor:
Rua M. Mukhtar, Nihal Abdelmoniem, Hisham A. Elrufaie, Alaa Edris, Hiba Ghaboosh, Mohanad A. Mahgoub, Elrashied A. E. Garelnabi, Wadah Osman, Asmaa E. Sherif, Ahmed Ashour, Kholoud F. Ghazawi, Waad A. Samman, Aisha A. Alhaddad, Rawan Bafail, Sabrin R. M. Ibrahim, Gamal A. Mohamed, Abdulrahim A. Alzain
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Tropomyosin-receptor kinase A (TrkA) is the primary isoform among the tropomyosin-receptor kinases that have been associated with human cancer development, contributing to approximately 7.4% of all cancer cases. TrkA represents an attractive target f
Externí odkaz:
https://doaj.org/article/aa633d32a35748db8b9b28e5292dd174