Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy

Autor: Matthias R. Lambert, Emanuela Gussoni

Publikováno v: Skeletal Muscle, Vol 13, Iss 1, Pp 1-18 (2023)

Abstract The tropomyosin genes (TPM1-4) contribute to the functional diversity of skeletal muscle fibers. Since its discovery in 1988, the TPM3 gene has been recognized as an indispensable regulator of muscle contraction in slow muscle fibers. Recent

Externí odkaz: https://doaj.org/article/b84bc009df984d0481b3726d61a9edce

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PolyC-RNA-binding protein 1 (PCBP1) enhances tropomyosin 3 (TPM3) mRNA stability to promote the progression of esophageal squamous cell carcinoma

Autor: Kaiming, Peng, Xiaoqiang, Chen, Anqin, Lin, Zhangwei, Tong, Wenwei, Lin

Publikováno v: Bioengineered. 13:8581-8592

The molecular etiology of esophageal squamous cell carcinoma (ESCC) has not been fully elucidated. Understanding the molecular mechanisms and finding new therapeutic targets for ESCC are of crucial importance. PolyC-RNA-binding protein 1 (PCBP1) is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d27872ddf975e2607312f436bef319
https://doi.org/10.1080/21655979.2022.2053801

The R168G heterozygous mutation of tropomyosin 3 (TPM3) was identified in three family members and has manifestations ranging from asymptotic to serve scoliosis and respiratory complications.

Autor: Xu H; Department of Orthopedic, Chongqing Children's Hospital, Chongqing Medical University, No. 136 of Zhong Shan Er Lu, Chongqing, 400014, PR China., Liu H; Department of Orthopedic, Chongqing Children's Hospital, Chongqing Medical University, No. 136 of Zhong Shan Er Lu, Chongqing, 400014, PR China., Chen T; Department of Orthopedic, Chongqing Children's Hospital, Chongqing Medical University, No. 136 of Zhong Shan Er Lu, Chongqing, 400014, PR China., Song B; Department of Orthopedic, Chongqing Children's Hospital, Chongqing Medical University, No. 136 of Zhong Shan Er Lu, Chongqing, 400014, PR China., Zhu J; Department of Pathology, Chongqing Children's Hospital, Chongqing Medical University, No. 136 of Zhong Shan Er Lu, Chongqing, 400014, PR China., Liu X; Department of Orthopedic, Chongqing Children's Hospital, Chongqing Medical University, No. 136 of Zhong Shan Er Lu, Chongqing, 400014, PR China.; Molecular Oncology Laboratory, Department of Orthopaedic Surgery, The University of Chicago Medical Center, Chicago, IL 60637, USA., Li M; Department of Orthopedic, Chongqing Children's Hospital, Chongqing Medical University, No. 136 of Zhong Shan Er Lu, Chongqing, 400014, PR China., Luo C; Department of Orthopedic, Chongqing Children's Hospital, Chongqing Medical University, No. 136 of Zhong Shan Er Lu, Chongqing, 400014, PR China.

Publikováno v: Genes & diseases [Genes Dis] 2020 Jan 25; Vol. 8 (5), pp. 715-720. Date of Electronic Publication: 2020 Jan 25 (Print Publication: 2021).

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