Zobrazeno 1 - 10
of 955
pro vyhledávání: '"Trono, P"'
Classification algorithms using RNA-Sequencing (RNA-Seq) data as input are used in a variety of biological applications. By nature, RNA-Seq data is subject to uncontrolled fluctuations both within and especially across datasets, which presents a majo
Externí odkaz:
http://arxiv.org/abs/2301.04653
Autor:
Nikolaos M. R. Lykoskoufis, Evarist Planet, Halit Ongen, Didier Trono, Emmanouil T. Dermitzakis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Transposable elements (TEs) are prevalent repeats in the human genome, play a significant role in the regulome, and their disruption can contribute to tumorigenesis. However, TE influence on gene expression in cancer remains unclear. Here, w
Externí odkaz:
https://doaj.org/article/751f2c122b234bc69f931cf20a362f13
Autor:
Norman Moullan, Josephat Asiago, Kathryn Stecco, Salah Hadi, Moetaz Albizem, Holly Tieu, Björn Hock, Craig Fenwick, Kai Lin, Thomas Lengsfeld, Lauren Poffenbarger, David Liu, Didier Trono, Giuseppe Pantaleo, Rajeev Venkayya, Prakash Bhuyan
Publikováno v:
Infectious Diseases and Therapy, Vol 13, Iss 1, Pp 173-187 (2024)
Abstract Introduction COVID-19 remains a significant risk for the immunocompromised given their lower responsiveness to vaccination or infection. Therefore, passive immunity through long-acting monoclonal antibodies (mAbs) offers a needed approach fo
Externí odkaz:
https://doaj.org/article/ae010852240d435b8fc87f0fafd48f33
Autor:
María Aldana Vissani, Florencia Alamos, María Silvia Tordoya, Leonardo Minatel, Juan Manuel Schammas, María José Dus Santos, Karina Trono, María E. Barrandeguy, Udeni B. R. Balasuriya, Mariano Carossino
Publikováno v:
Viruses, Vol 16, Iss 10, p 1594 (2024)
Western equine encephalitis virus (WEEV) is a mosquito-borne arbovirus (genus Alphavirus, family Togaviridae) that has re-emerged in South America in late 2023, causing severe disease in both horses and humans after a nearly 40-year intermission peri
Externí odkaz:
https://doaj.org/article/1d8f50b9faef4622a7d3dd0eeee11baa
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-21 (2023)
Abstract In recent years, research focused on the multifaceted landscape and functions of cancer-associated fibroblasts (CAFs) aimed to reveal their heterogeneity and identify commonalities across diverse tumors for more effective therapeutic targeti
Externí odkaz:
https://doaj.org/article/e09281ff7fdb4567b0b0bb9f575a4fa5
Autor:
Francisco S. Mesquita, Laurence Abrami, Lucie Bracq, Nattawadee Panyain, Vincent Mercier, Béatrice Kunz, Audrey Chuat, Joana Carlevaro-Fita, Didier Trono, F. Gisou van der Goot
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract SARS-CoV-2 infection requires Spike protein-mediated fusion between the viral and cellular membranes. The fusogenic activity of Spike depends on its post-translational lipid modification by host S-acyltransferases, predominantly ZDHHC20. Pre
Externí odkaz:
https://doaj.org/article/c0981672337f4d919ad77a75de8bbe28
Autor:
Cyril Pulver, Delphine Grun, Julien Duc, Shaoline Sheppard, Evarist Planet, Alexandre Coudray, Raphaël de Fondeville, Julien Pontis, Didier Trono
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-40 (2023)
Abstract Background Transposable elements (TEs) have colonized the genomes of most metazoans, and many TE-embedded sequences function as cis-regulatory elements (CREs) for genes involved in a wide range of biological processes from early embryogenesi
Externí odkaz:
https://doaj.org/article/e4b7bc915ee949289443e890c3baf6b7
Akademický článek
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Akademický článek
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Autor:
Julien Pontis, Cyril Pulver, Christopher J. Playfoot, Evarist Planet, Delphine Grun, Sandra Offner, Julien Duc, Andrea Manfrin, Matthias P. Lutolf, Didier Trono
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The human genome harbors more than 4.5 million transposable element (TE)-derived insertions, the result of recurrent waves of invasion and internal propagation. Here they show that TEs belonging to evolutionarily recent subfamilies go on to regulate
Externí odkaz:
https://doaj.org/article/e82e220d3511449c9d94b1deeffca8a6