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Akademický článek
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Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
Abstract Background Shigella is a Gram-negative facultative intracellular bacterium that causes bacillary dysentery in humans. Shigella invades cells of the colonic mucosa owing to its virulence plasmid-encoded Type 3 Secretion System (T3SS), and mul
Externí odkaz:
https://doaj.org/article/a060408dabd6405298950f671a8e68b7
Autor:
Sophie Tronnet, Pauline Floch, Laetitia Lucarelli, Deborah Gaillard, Patricia Martin, Matteo Serino, Eric Oswald
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
ABSTRACT The genotoxin colibactin produced by resident bacteria of the gut microbiota may have tumorigenic effect by inducing DNA double-strand breaks in host cells. Yet, the effect of colibactin on gut microbiota composition and functions remains un
Externí odkaz:
https://doaj.org/article/f2626c92bee94e42a1a121d345194193
Autor:
Teresa Pérez-Berezo, Julien Pujo, Patricia Martin, Pauline Le Faouder, Jean-Marie Galano, Alexandre Guy, Claude Knauf, Jean Claude Tabet, Sophie Tronnet, Frederick Barreau, Maud Heuillet, Gilles Dietrich, Justine Bertrand-Michel, Thierry Durand, Eric Oswald, Nicolas Cenac
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Escherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial b
Externí odkaz:
https://doaj.org/article/14fbaec632884e6fbafc02bc5cea62fa
Autor:
Camille V. Chagneau, Christophe Garcie, Nadège Bossuet-Greif, Sophie Tronnet, Alexander O. Brachmann, Jörn Piel, Jean-Philippe Nougayrède, Patricia Martin, Eric Oswald
Publikováno v:
mSphere, Vol 4, Iss 5 (2019)
ABSTRACT Colibactin is a polyketide/nonribosomal peptide produced by Escherichia coli strains that harbor the pks island. This toxin induces DNA double-strand breaks and DNA interstrand cross-links in infected eukaryotic cells. Colibactin-producing s
Externí odkaz:
https://doaj.org/article/f385369a64724228830f1876acd7b499
Autor:
Garcie, Christophe, Tronnet, Sophie, Garénaux, Amélie, McCarthy, Alex J., Brachmann, Alexander O., Pénary, Marie, Houle, Sébastien, Nougayrède, Jean-Philippe, Piel, Jörn, Taylor, Peter W., Dozois, Charles M., Genevaux, Pierre, Oswald, Eric, Martin, Patricia
Publikováno v:
The Journal of Infectious Diseases, 2016 Sep . 214(6), 916-924.
Externí odkaz:
http://www.jstor.org/stable/44007168
Autor:
Sophie Tronnet, Eric Oswald
Publikováno v:
Bio-Protocol, Vol 8, Iss 6 (2018)
The genotoxin colibactin is produced by several species of Enterobacteriaceae. This genotoxin induces DNA damage, cell cycle arrest, senescence and death in eukaryotic cells (Nougayrède et al., 2006; Taieb et al., 2016). Here we describe a method to
Externí odkaz:
https://doaj.org/article/e2e60f8b30a64275b78711b00f51edc5
Autor:
Pedro Salas-Ambrosio, Antoine Tronnet, Mostafa Badreldin, Luzangel Reyes, Marc Since, Sandra Bourgeade-Delmas, Bruno Dupuy, Pierre Verhaeghe, Colin Bonduelle
Publikováno v:
Polymer Chemistry
Polymer Chemistry, 2022, 13 (5), pp.600-612. ⟨10.1039/D1PY01529J⟩
Polymer Chemistry, 2022, 13 (5), pp.600-612. ⟨10.1039/D1PY01529J⟩
International audience; We developed new macromolecular engineering approaches enabling the preparation of star-like polypeptoids by ring-opening polymerization. Parallely to the evaluation of their cytotoxicity of the HepG2 human cell line, their sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4318ea43d34e094ec22ad35e3de1489e
https://doi.org/10.1039/d1py01529j
https://doi.org/10.1039/d1py01529j
Autor:
Pedro Salas-Ambrosio, Antoine Tronnet, Mostafa Badreldin, Sifan Ji, Sebastien Lecommandoux, Simon Harrisson, Pierre Verhaeghe, Colin Bonduelle
Publikováno v:
Polymer Chemistry
Polymer Chemistry, 2022, 13, pp.6149-6161. ⟨10.1039/D2PY00985D⟩
Polymer Chemistry, 2022, 13, pp.6149-6161. ⟨10.1039/D2PY00985D⟩
International audience; Polypeptoids are an emerging class of biomimetic polymers prepared by ring-opening polymerization (ROP) of N-alkylated-N-carboxyanhydride (NNCA) monomers. The N-alkylation provides a unique structural isomerism with peptides b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da0fa9d437ed8543600201c4f6dc857
https://doi.org/10.1039/d2py00985d
https://doi.org/10.1039/d2py00985d