Demethoxycurcumin Is A Potent Inhibitor of P-Type ATPases from Diverse Kingdoms of Life.

Autor: Trong Tuan Dao, Pankaj Sehgal, Truong Thanh Tung, Jesper Vuust Møller, John Nielsen, Michael Palmgren, Søren Brøgger Christensen, Anja Thoe Fuglsang

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0163260 (2016)

P-type ATPases catalyze the active transport of cations and phospholipids across biological membranes. Members of this large family are involved in a range of fundamental cellular processes. To date, a substantial number of P-type ATPase inhibitors h

Externí odkaz: https://doaj.org/article/fab7a7c2f8b941eba66264679c563629

Cladobotric Acids: Metabolites from Cultures of Cladobotryum sp., Semisynthetic Analogues and Antibacterial Activity

Autor: Trong-Tuan Dao, Katherine Williams, Kate M. J. de Mattos-Shipley, Zhongshu Song, Yuiko Takebayashi, Thomas J. Simpson, James Spencer, Andrew M. Bailey, Christine L. Willis

Publikováno v: Dao, T T, Williams, K, de Mattos-Shipley, K M J, Song, Z, Takebayashi, Y, Simpson, T J, Spencer, J, Bailey, A M & Willis, C L 2022, ' Cladobotric acids: Metabolites from cultures of Cladobotryum sp., semi-synthetic analogues and antibacterial activity ', Journal of Natural Products, vol. 85, no. 3, pp. 572-580 . https://doi.org/10.1021/acs.jnatprod.1c01063

Three new polyketide-derived natural products, cladobotric acids G–I (1–3), and six known metabolites (4, 5, 8–11) were isolated from fermentation of the fungus Cladobotryum sp. grown on rice. Their structures were elucidated by extensive spect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7e5b2521ebfde65846ed25cb388880
https://doi.org/10.1021/acs.jnatprod.1c01063

Cleaning the Cellular Factory–Deletion of McrA in Aspergillus oryzae NSAR1 and the Generation of a Novel Kojic Acid Deficient Strain for Cleaner Heterologous Production of Secondary Metabolites

Autor: Katherine Williams, Trong Tuan Dao, Colin M. Lazarus, Christine L. Willis, Kate M. J. de Mattos-Shipley, Andy M. Bailey, Marija K Zacharova, Ian M. Prosser

Publikováno v: Dao, T T, De Mattos-Shipley, K M, Prosser, I M, Williams, K, Zacharova, M K, Lazarus, C M, Willis, C L & Bailey, A M 2021, ' Cleaning the Cellular Factory : Deletion of McrA in Aspergillus oryzae NSAR1 and the generation of a novel kojic acid deficient strain for cleaner heterologous production of secondary metabolites ', Frontiers in Fungal Biology, vol. 2, no. 632542 . https://doi.org/10.3389/ffunb.2021.632542

The use of filamentous fungi as cellular factories, where natural product pathways can be refactored and expressed in a host strain, continues to aid the field of natural product discovery. Much work has been done to develop host strains which are ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d285edc027df24b10cb4da54588a90c3
https://doi.org/10.3389/ffunb.2021.632542

Cladobotric Acids: Metabolites from Cultures of sp., Semisynthetic Analogues and Antibacterial Activity.

Autor: Trong-Tuan Dao, Williams, Katherine, de Mattos-Shipley, Kate M. J., Zhongshu Song, Yuiko Takebayashi, Simpson, Thomas J., Spencer, James, Bailey, Andrew M., Willis, Christine L., Dao, Trong-Tuan, Song, Zhongshu, Takebayashi, Yuiko

Publikováno v: Journal of Natural Products; 3/25/2022, Vol. 85 Issue 3, p572-580, 9p

Triolein from Coix Lacryma-Jobi Induces Cell Cycle Arrest through P53/P21Signaling Pathway

Autor: Do Minh Truong, Nguyen Thanh Hai, Bui Thi Binh, Loi Vu Duc, Thi Hien Tran, Do Thi Ha, Trong Tuan Dao

Publikováno v: Biomedical and Pharmacology Journal. 9:519-524

p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cee646b68d1da400cbb5d410aee0eb4e
https://doi.org/10.13005/bpj/967