Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Trond-André Kråkenes"'
Autor:
María Teresa Bueno-Carrasco, Jorge Cuéllar, Marte I. Flydal, César Santiago, Trond-André Kråkenes, Rune Kleppe, José R. López-Blanco, Miguel Marcilla, Knut Teigen, Sara Alvira, Pablo Chacón, Aurora Martinez, José M. Valpuesta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the catecholamine neurotransmitters and hormones dopamine (DA), adrenaline and noradrenaline. Here, the authors present the cryo-EM structures of full-length human TH in t
Externí odkaz:
https://doaj.org/article/3b54c91d09444b37ba25ca02cc815dcd
Autor:
Trond-André Kråkenes, Mary Dayne S. Tai, Marte I. Flydal, Aurora Martinez, Knut Teigen, Maria P.A. Tran
Publikováno v:
Biochimie. 183:126-132
Tyrosine hydroxylase (TH) catalyses the (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4)-dependent conversion of L-tyrosine to L-3,4-dihydroxyphenylalanine (L-Dopa), which is the rate-limiting step in the synthesis of dopamine and other catecholamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6115a0bbf828ee9e47299b4fcb9e71
https://doi.org/10.1016/j.biochi.2020.12.002
https://doi.org/10.1016/j.biochi.2020.12.002
Autor:
Aurora Martinez, Maria Teresa Bezem, Fredrik Gullaksen Johannessen, Michael J. Sailor, Trond-André Kråkenes
Publikováno v:
Molecular Pharmaceutics
Tyrosine hydroxylase (TH) is the enzyme catalyzing the rate-limiting step in the synthesis of dopamine in the brain. Developing enzyme replacement therapies using TH could therefore be beneficial to patient groups with dopamine deficiency, and the us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641b8a60bdb553c47b2c668f5f13c376
https://doi.org/10.1021/acs.molpharmaceut.0c00960
https://doi.org/10.1021/acs.molpharmaceut.0c00960
Autor:
Knut Teigen, José Ramón López-Blanco, Pablo Chacón, Jorge Cuéllar, Rune Kleppe, Aurora Martinez, César Santiago, Marte I. Flydal, José M. Valpuesta, Trond-André Kråkenes, Sara Alvira, Teresa Bueno-Carrasco
Tyrosine hydroxylase (TH) is a highly regulated enzyme that catalyses the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines. Mutations and dysfunction in this enzyme lead to DA deficiency and parkinsonisms of different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03a8c8befef21a868f87c0a99aa3f0d4
https://doi.org/10.21203/rs.3.rs-64971/v1
https://doi.org/10.21203/rs.3.rs-64971/v1
