Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Trond Stokke"'
Publikováno v:
Bio-Protocol, Vol 13, Iss 8 (2023)
RNA polymerase II (RNAPII) transcribes DNA into mRNA and thereby plays a critical role in cellular protein production. In addition, RNAPII plays a central role in DNA damage responses. Measurements of RNAPII on chromatin may thus give insight into se
Externí odkaz:
https://doaj.org/article/f04982ebd98b4d418ed0d1102d91b2fc
Autor:
Anja Nilsen, Tiril Hillestad, Vilde E. Skingen, Eva‐Katrine Aarnes, Christina S. Fjeldbo, Tord Hompland, Tina Sandø Evensen, Trond Stokke, Gunnar B. Kristensen, Beata Grallert, Heidi Lyng
Publikováno v:
Molecular Oncology, Vol 16, Iss 6, Pp 1402-1419 (2022)
Many patients with locally advanced cervical cancer experience recurrence within the radiation field after chemoradiotherapy. Biomarkers of tumor radioresistance are required to identify patients in need of intensified treatment. Here, the biomarker
Externí odkaz:
https://doaj.org/article/93f75c6bb99d41ab923b3b2b4e9c7452
Autor:
Morten P. Oksvold, Ulrika Warpman Berglund, Helge Gad, Baoyan Bai, Trond Stokke, Idun Dale Rein, Therese Pham, Kumar Sanjiv, Geir Frode Øy, Jens Henrik Norum, Erlend B. Smeland, June H. Myklebust, Thomas Helleday, Thea Kristin Våtsveen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Chemo-immunotherapy has improved survival in B-cell lymphoma patients, but refractory/relapsed diseases still represent a major challenge, urging for development of new therapeutics. Karonudib (TH1579) was developed to inhibit MTH1, an enzym
Externí odkaz:
https://doaj.org/article/2bf70b7f4423442fb0d96f1650f44291
Autor:
Marion M Malenge, Astri Fjelde Maaland, Ada Repetto-Llamazares, Brian Middleton, Marcel Nijland, Lydia Visser, Sebastian Patzke, Helen Heyerdahl, Arne Kolstad, Trond Stokke, Anne Hansen Ree, Jostein Dahle
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0267543 (2022)
Background and purposePARP inhibitors have been shown to increase the efficacy of radiotherapy in preclinical models. Radioimmunotherapy results in selective radiation cytotoxicity of targeted tumour cells. Here we investigate the combined effect of
Externí odkaz:
https://doaj.org/article/0ff57784aa0f4af780996246d2a8a7e3
Autor:
Marte Jonsson, Christina Sæten Fjeldbo, Ruth Holm, Trond Stokke, Gunnar Balle Kristensen, Heidi Lyng
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 4, Pp 353-362 (2019)
CDK regulatory subunit 2 (CKS2) has a nuclear function that promotes cell division and is a candidate biomarker of chemoradioresistance in cervical cancer. The underlying mechanisms are, however, not completely understood. We investigated whether CKS
Externí odkaz:
https://doaj.org/article/f7cc999a4e3f446098cf1f3d02df8a35
Autor:
Kari-Anne M. Frikstad, Elisa Molinari, Marianne Thoresen, Simon A. Ramsbottom, Frances Hughes, Stef J.F. Letteboer, Sania Gilani, Kay O. Schink, Trond Stokke, Stefan Geimer, Lotte B. Pedersen, Rachel H. Giles, Anna Akhmanova, Ronald Roepman, John A. Sayer, Sebastian Patzke
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1907-1922.e6 (2019)
Summary: CEP104 is an evolutionarily conserved centrosomal and ciliary tip protein. CEP104 loss-of-function mutations are reported in patients with Joubert syndrome, but their function in the etiology of ciliopathies is poorly understood. Here, we sh
Externí odkaz:
https://doaj.org/article/64cd3655c3764130ba8e0811b1fe5fe9
Autor:
Johan Sternemalm, Stefan Geimer, Kari-Anne M Frikstad, Kay O Schink, Trond Stokke, Sebastian Patzke
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134789 (2015)
Deleterious mutations of the Centrosome/Spindle Pole associated Protein 1 gene, CSPP1, are causative for Joubert-syndrome and Joubert-related developmental disorders. These disorders are defined by a characteristic mal-development of the brain, but f
Externí odkaz:
https://doaj.org/article/dce97ab5960547fd95facee072d143e8
Autor:
Jon Halvor Jonsrud Knutsen, Idun Dale Rein, Christiane Rothe, Trond Stokke, Beáta Grallert, Erik Boye
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17175 (2011)
The cell cycle of the fission yeast, Schizosaccharomyces pombe, does not easily lend itself to analysis by flow cytometry, mainly because cells in G(1) and G(2) phase contain the same amount of DNA. This occurs because fission yeast cells under stand
Externí odkaz:
https://doaj.org/article/c03b9dae075b45529f13719fcdb2d898
Autor:
Yuanyuan Ma, Dongming Liang, Jian Liu, Karol Axcrona, Gunnar Kvalheim, Trond Stokke, Jahn M Nesland, Zhenhe Suo
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29170 (2011)
Hypoxia is an important environmental change in many cancers. Hypoxic niches can be occupied by cancer stem/progenitor-like cells that are associated with tumor progression and resistance to radiotherapy and chemotherapy. However, it has not yet been
Externí odkaz:
https://doaj.org/article/7274d7e943f745c480a5d05352698b1f
Autor:
Malin Lando, Marit Holden, Linn C Bergersen, Debbie H Svendsrud, Trond Stokke, Kolbein Sundfør, Ingrid K Glad, Gunnar B Kristensen, Heidi Lyng
Publikováno v:
PLoS Genetics, Vol 5, Iss 11, p e1000719 (2009)
Integrative analysis of gene dosage, expression, and ontology (GO) data was performed to discover driver genes in the carcinogenesis and chemoradioresistance of cervical cancers. Gene dosage and expression profiles of 102 locally advanced cervical ca
Externí odkaz:
https://doaj.org/article/e4e6bd4517c540658eebd15dd8257ae6