Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Trond Myhrer"'
Publikováno v:
Toxicology Reports, Vol 1, Iss C, Pp 102-113 (2014)
Four medical therapies previously shown to exert varying degrees of protection against a convulsant dose of soman were assessed for potential behavioral side effects in a novelty test. In Experiment 1, HI-6 (1-[([4-(aminocarbonyl)pyridino] methoxy)me
Externí odkaz:
https://doaj.org/article/329b5b6c495641d8a0ca95b5367bbcfb
Publikováno v:
NeuroToxicology. 65:144-165
Nerve agent-induced seizures can cause varying degrees of neuropathology depending on level of poisoning and duration of seizing. The intention of this review was to validate a novel approach for establishing effective treatment regimens against soma
Publikováno v:
Toxicology. 314:221-228
A treatment regimen consisting of HI-6, scopolamine, and physostigmine (termed the physostigmine regimen) has been based on the serendipitous discovery that it exerts powerful antidotal effects against high levels of soman poisoning if it is administ
Publikováno v:
European Journal of Pharmacology. 718:253-260
Current treatment of nerve agent poisoning with ionotropic drugs proves inadequate, and alternative treatment strategies are searched for. Based on positive findings with metabotropic glutamate modulators in microinfusion studies, the present study w
Publikováno v:
NeuroToxicology. 34:128-134
Microinfusion of anticonvulsants into the perirhinal cortex through 1 guide cannula in each hemisphere only invades a small area of this seizure controlling site in rats exposed to soman. The purpose of the present study was to examine whether infusi
Autor:
Pål Aas, Trond Myhrer
Publikováno v:
Neuroscience and biobehavioral reviews. 71
The threat of chemical warfare agents like nerve agents requires life saving measures of medical pretreatment combined with treatment after exposure. Pretreatment (pyridostigmine) may cause some side effects in a small number of individuals. A compre
Publikováno v:
Drug Testing and Analysis. 5:693-701
More effective countermeasures against nerve-agent poisoning are needed, because current ones do not protect sufficiently, particularly the central nervous system (CNS). The purpose of the present study was to make a comparison of the antidotal capab
Publikováno v:
NeuroToxicology. 32:923-930
Results from studies based on microinfusions into seizure controlling brain sites (area tempestas, medial septum, perirhinal cortex, posterior piriform cortex) have shown that procyclidine, muscimol, caramiphen, and NBQX, but not ketamine, exert anti
Publikováno v:
Pharmacology Biochemistry and Behavior. 95:338-343
Acetylcholinesterase inhibitors in combination with an anticholinergic, particularly anticholinergics with antiglutamatergic properties, can effectively protect against nerve agent-induced seizures and lethality. The objective of the present study wa
Publikováno v:
NeuroToxicology. 31:147-153
Identification of critical receptors in seizure controlling brain regions may facilitate the development of more efficacious pharmacological therapies against nerve agent intoxication. In the present study, a number of drugs with anticonvulsant poten