Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Trond, Stokke"'
Publikováno v:
Bio-Protocol, Vol 13, Iss 8 (2023)
RNA polymerase II (RNAPII) transcribes DNA into mRNA and thereby plays a critical role in cellular protein production. In addition, RNAPII plays a central role in DNA damage responses. Measurements of RNAPII on chromatin may thus give insight into se
Externí odkaz:
https://doaj.org/article/f04982ebd98b4d418ed0d1102d91b2fc
Autor:
Anja Nilsen, Tiril Hillestad, Vilde E. Skingen, Eva‐Katrine Aarnes, Christina S. Fjeldbo, Tord Hompland, Tina Sandø Evensen, Trond Stokke, Gunnar B. Kristensen, Beata Grallert, Heidi Lyng
Publikováno v:
Molecular Oncology, Vol 16, Iss 6, Pp 1402-1419 (2022)
Many patients with locally advanced cervical cancer experience recurrence within the radiation field after chemoradiotherapy. Biomarkers of tumor radioresistance are required to identify patients in need of intensified treatment. Here, the biomarker
Externí odkaz:
https://doaj.org/article/93f75c6bb99d41ab923b3b2b4e9c7452
Autor:
Morten P. Oksvold, Ulrika Warpman Berglund, Helge Gad, Baoyan Bai, Trond Stokke, Idun Dale Rein, Therese Pham, Kumar Sanjiv, Geir Frode Øy, Jens Henrik Norum, Erlend B. Smeland, June H. Myklebust, Thomas Helleday, Thea Kristin Våtsveen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Chemo-immunotherapy has improved survival in B-cell lymphoma patients, but refractory/relapsed diseases still represent a major challenge, urging for development of new therapeutics. Karonudib (TH1579) was developed to inhibit MTH1, an enzym
Externí odkaz:
https://doaj.org/article/2bf70b7f4423442fb0d96f1650f44291
Autor:
Marion M Malenge, Astri Fjelde Maaland, Ada Repetto-Llamazares, Brian Middleton, Marcel Nijland, Lydia Visser, Sebastian Patzke, Helen Heyerdahl, Arne Kolstad, Trond Stokke, Anne Hansen Ree, Jostein Dahle
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0267543 (2022)
Background and purposePARP inhibitors have been shown to increase the efficacy of radiotherapy in preclinical models. Radioimmunotherapy results in selective radiation cytotoxicity of targeted tumour cells. Here we investigate the combined effect of
Externí odkaz:
https://doaj.org/article/0ff57784aa0f4af780996246d2a8a7e3
Autor:
Marte Jonsson, Christina Sæten Fjeldbo, Ruth Holm, Trond Stokke, Gunnar Balle Kristensen, Heidi Lyng
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 4, Pp 353-362 (2019)
CDK regulatory subunit 2 (CKS2) has a nuclear function that promotes cell division and is a candidate biomarker of chemoradioresistance in cervical cancer. The underlying mechanisms are, however, not completely understood. We investigated whether CKS
Externí odkaz:
https://doaj.org/article/f7cc999a4e3f446098cf1f3d02df8a35
Autor:
Kari-Anne M. Frikstad, Elisa Molinari, Marianne Thoresen, Simon A. Ramsbottom, Frances Hughes, Stef J.F. Letteboer, Sania Gilani, Kay O. Schink, Trond Stokke, Stefan Geimer, Lotte B. Pedersen, Rachel H. Giles, Anna Akhmanova, Ronald Roepman, John A. Sayer, Sebastian Patzke
Publikováno v:
Cell Reports, Vol 28, Iss 7, Pp 1907-1922.e6 (2019)
Summary: CEP104 is an evolutionarily conserved centrosomal and ciliary tip protein. CEP104 loss-of-function mutations are reported in patients with Joubert syndrome, but their function in the etiology of ciliopathies is poorly understood. Here, we sh
Externí odkaz:
https://doaj.org/article/64cd3655c3764130ba8e0811b1fe5fe9
Autor:
Heidi Lyng, Trond Stokke, Gunnar B. Kristensen, Tina S. Evensen, Kjersti V. Lund, Anja Nilsen, Eva-Katrine Aarnes, Unn Beate Salberg, Vilde E. Skingen, Christina S. Fjeldbo, Tord Hompland, Tiril Hillestad
Comparison of MRI with histology, construction of hypoxia images, and hypoxia levels in patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534b8515291f0caf041ed9f9a7e5b6e5
https://doi.org/10.1158/0008-5472.22426381.v1
https://doi.org/10.1158/0008-5472.22426381.v1
Autor:
Heidi Lyng, Trond Stokke, Gunnar B. Kristensen, Tina S. Evensen, Kjersti V. Lund, Anja Nilsen, Eva-Katrine Aarnes, Unn Beate Salberg, Vilde E. Skingen, Christina S. Fjeldbo, Tord Hompland, Tiril Hillestad
DCE-MRI and digital histopathology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55943b12760648b3c3ea3d93faa2d55e
https://doi.org/10.1158/0008-5472.22426378.v1
https://doi.org/10.1158/0008-5472.22426378.v1
Autor:
Heidi Lyng, Trond Stokke, Gunnar B. Kristensen, Tina S. Evensen, Kjersti V. Lund, Anja Nilsen, Eva-Katrine Aarnes, Unn Beate Salberg, Vilde E. Skingen, Christina S. Fjeldbo, Tord Hompland, Tiril Hillestad
Validation of algorithm for assessing hypoxia levels in patient tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ea1f311756ee7a7fa2f23c7cd60877
https://doi.org/10.1158/0008-5472.22426384.v1
https://doi.org/10.1158/0008-5472.22426384.v1
Autor:
Heidi Lyng, Trond Stokke, Gunnar B. Kristensen, Tina S. Evensen, Kjersti V. Lund, Anja Nilsen, Eva-Katrine Aarnes, Unn Beate Salberg, Vilde E. Skingen, Christina S. Fjeldbo, Tord Hompland, Tiril Hillestad
Tumor hypoxia levels range from mild to severe and have different biological and therapeutical consequences but are not easily assessable in patients. Here we present a method based on diagnostic dynamic contrast enhanced (DCE) MRI that reflects a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac52bcc9174ad1c5aa9898390e40ca1
https://doi.org/10.1158/0008-5472.c.6512323.v1
https://doi.org/10.1158/0008-5472.c.6512323.v1