A.6 INDIGO: a global, randomized, double-blinded, Phase 3 study of vorasidenib versus placebo in patients with grade 2 glioma with an IDH1/2 mutation (mIDH1/2)

Autor: Perry, JR, Mellinghoff, IK, van den Bent, M, Blumenthal, DT, Touat, M, Peters, KB, Clarke, J, Mendez, J, Yust-Katz, S, Mason, W, Ducray, F, Umemura, Y, Nabors, B, Holdhoff, M, Hottinger, AF, Arakawa, Y, Sepúlveda, J, Wick, W, Soffietti, R, Giglio, P, de la Fuente, M, Maher, E, Ellingson, BM, Bottomley, A, Zhao, D, Pandya, SS, Tron, AE, Steelman, L, Hassan, I, Wen, PY, Cloughesy, TF

Publikováno v: The Canadian Journal of Neurological Sciences; June 2024, Vol. 51 Issue: Supplement 1 pS4-S4, 1p

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Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity.

Autor: Wu MJ; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Kondo H; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Kammula AV; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Shi L; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Xiao Y; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Dhiab S; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Xu Q; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Slater CJ; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Universite Paris-Saclay, Institut Gustave Roussy, INSERM U1015, Villejuif, France.; Servier Pharmaceuticals LLC, Boston, MA, USA., Avila OI; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Merritt J; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Kato H; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Kattel P; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Sussman J; Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Graduate Group in Genomics and Computational Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Gritti I; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Eccleston J; Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Sun Y; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA., Cho HM; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Olander K; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Katsuda T; Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Shi DD; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA, USA., Savani MR; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX, USA., Smith BC; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA., Cleary JM, Mostoslavsky R; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Vijay V; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Kitagawa Y; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Wakimoto H; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jenkins RW; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, MA, USA., Yates KB; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Paik J; Department of Pathology and Laboratory Medicine, Sandra and Edward Meyer Cancer Center, Weill Medical College of Cornell University, New York, NY, USA., Tassinari A; Servier Pharmaceuticals LLC, Boston, MA, USA., Saatcioglu DH; Servier Pharmaceuticals LLC, Boston, MA, USA., Tron AE; Servier Pharmaceuticals LLC, Boston, MA, USA., Haas W; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Cahill D; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., McBrayer SK; Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA., Manguso RT; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Bardeesy N; Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Jul 12; Vol. 385 (6705), pp. eadl6173. Date of Electronic Publication: 2024 Jul 12.

Safety, efficacy, and PK/PD of vorasidenib in previously treated patients with mIDH1/2 hematologic malignancies: A phase 1 study.

Autor: DiNardo CD; MD Anderson Cancer Center, University of Texas, Houston, Texas, USA., De Botton S; Institut Gustave Roussy, Villejuif, France., Pollyea DA; Division of Hematology, School of Medicine, University of Colorado, Aurora, Colorado, USA., Stone RM; Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Altman JK; Northwestern University, Chicago, Illinois, USA., Fathi AT; Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Limsakun T; Servier BioInnovation LLC, Boston, Massachusetts, USA., Liang M; Agios Pharmaceuticals, Inc, Cambridge, Massachusetts, USA., Choe S; Servier BioInnovation LLC, Boston, Massachusetts, USA., Hossain M; Servier BioInnovation LLC, Boston, Massachusetts, USA., Tron AE; Servier BioInnovation LLC, Boston, Massachusetts, USA., Meng Q; Servier BioInnovation LLC, Boston, Massachusetts, USA., Kapsalis SM; Servier BioInnovation LLC, Boston, Massachusetts, USA., Pandya SS; Servier BioInnovation LLC, Boston, Massachusetts, USA., Stein EM; Memorial Sloan Kettering Cancer Center, New York City, New York, USA.

Publikováno v: American journal of hematology [Am J Hematol] 2023 Sep; Vol. 98 (9), pp. E233-E236. Date of Electronic Publication: 2023 Jun 24.