Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Troii, Hall"'
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1096
Hydrophobic interaction chromatography (HIC) is routinely used in the purification of biopharmaceuticals such as antibodies. However, hydrophobic proteins can be difficult to elute resulting in low recovery of product thereby complicating early phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58049029f5bc9c8beba719178cc7ccf5
https://pubmed.ncbi.nlm.nih.gov/30130673
https://pubmed.ncbi.nlm.nih.gov/30130673
Autor:
Bo Qi, Stanley Ng, Richard Chen, Martha L Healy-Fried, Josaih C Adaelu, Rajesh Ambat, Paul Balderes, Julia Lee, Troii Hall, Yun (Kenneth) Kang, Behnam Shanehsaz, William D Holmes, Dale L. Ludwig, Michael Barry, Matthew D Sauffer, Warren R. Emery, Amy Huebner
Publikováno v:
Pharmaceutical Bioprocessing. 3:477-487
6-Chloro- and 6-bromopurines can cross the blood-brain barrier and in situ give rise to substrates of multidrug resistance-associated proteins (MRPs). The electrophilic purines form glutathione conjugates in reactions catalyzed by intracellular gluta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf6e25f7cec067196cbc97bda8b19af
https://doi.org/10.4155/pbp.15.28
https://doi.org/10.4155/pbp.15.28
Autor:
Michelle Kraus, Jay M. Wendling, Olga V. Nemirovskiy, John W. Rains, Vincent Peterkin, Laura E. Zawadzke, Hideji Fujiwara, Ciarán N. Cronin, Troii Hall, Tom Kasten, Maureen K. Highkin, Gina M. Jerome, Arthur J. Wittwer, Matthew P. Yates, Shinji Ogawa, Jeffrey A. Scholten, Jill Chrencik, Marek M. Nagiec, Matthew D. McReynolds, Kaliapan Iyanar, Mark E. Schnute, Kristin Cukyne, Matthew J. Saabye, Richard M. Broadus
Publikováno v:
Biochemical Journal. 444:79-88
SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c29039f87435103ee01d57e1663842f
https://doi.org/10.1042/bj20111929
https://doi.org/10.1042/bj20111929
Autor:
Lyle E. Pegg, Jens Hausmann, Harald M. H. G. Albers, Leonie van Zeijl, Karl Harlos, Wouter H. Moolenaar, Susan S. Smyth, Evangelos Christodoulou, Jacqueline E. Day, Craig W. Vander Kooi, Mobien Kasiem, Andrew J. Morris, Timothy E. Benson, Anna J. S. Houben, Anastassis Perrakis, Maria Andries, Zachary Fulkerson, Mathieu Bollen, Tao Wu, Silvia Jansen, Satwik Kamtekar, Troii Hall, Laurens A. van Meeteren, Huib Ovaa
Publikováno v:
Nature Structural & Molecular Biology. 18:198-204
Autotaxin (ATX, also known as ectonucleotide pyrophosphatase/phosphodiesterase-2, ENPP2) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA), a mitogen and chemoattractant for many cell types. ATX-LPA signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0127ea71e1de23fd487334a953f7a46
https://doi.org/10.1038/nsmb.1980
https://doi.org/10.1038/nsmb.1980
Autor:
James R. Kiefer, Joseph W. Leone, Alfredo G. Tomasselli, Robin A. Weinberg, Akshay Patny, H. David Fischer, Cynthia D. Sommers, Jennifer A. Gormley, Timothy E. Benson, Horng-Chih Huang, E.J. Jacobsen, Jacqueline E. Day, Thomas L. Emmons, Jill Chrencik, Iris K. Leung, Jeffrey L. Hirsch, Tenbrink Ruth E, Jennifer M. Williams, Brian Korniski, Troii Hall
Publikováno v:
Journal of Molecular Biology. 400:413-433
Janus kinases (JAKs) are critical regulators of cytokine pathways and attractive targets of therapeutic value in both inflammatory and myeloproliferative diseases. Although the crystal structures of active JAK1 and JAK2 kinase domains have been repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b19fab0c9dc63112be2b1f9f66fc065
https://doi.org/10.1016/j.jmb.2010.05.020
https://doi.org/10.1016/j.jmb.2010.05.020
Autor:
Thomas L. Emmons, Alfredo G. Tomasselli, Robin A. Weinberg, H. David Fischer, Jill Chrencik, Brian Korniski, Jacqueline E. Day, Stacy Brown, Joseph W. Leone, Ann D. Wrightstone, Cynthia D. Sommers, Jeffrey L. Hirsch, Arthur J. Wittwer, Troii Hall, Jennifer A. Gormley
Publikováno v:
Biochemical and Biophysical Research Communications. 396:543-548
The Janus kinase family consists of four members: JAK-1, -2, -3 and TYK-2. While JAK-2 and JAK-3 have been well characterized biochemically, there is little data on TYK-2. Recent work suggests that TYK-2 may play a critical role in the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4568dae04b1e101103ca4b31d2d17487
https://doi.org/10.1016/j.bbrc.2010.04.141
https://doi.org/10.1016/j.bbrc.2010.04.141
Autor:
Thomas L. Emmons, James R. Kiefer, Joseph W. Leone, John F. Schindler, Melissa S. Harris, Jacqueline E. Day, Siradanahalli Guru, Alfredo G. Tomasselli, Robin A. Weinberg, Sandra Lightle, H. David Fischer, Jeffrey L. Hirsch, Jill Chrencik, Jennifer A. Gormley, Jennifer M. Williams, Matthew J. Saabye, Troii Hall
Publikováno v:
Protein Expression and Purification. 69:54-63
Janus-associated kinases (JAKs) play critical roles in cytokine signaling, and have emerged as viable therapeutic targets in inflammation and oncology related diseases. To date, targeting JAK proteins with highly selective inhibitor compounds have re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68adb1eba9066345bc1000db1eef31a2
https://doi.org/10.1016/j.pep.2009.09.011
https://doi.org/10.1016/j.pep.2009.09.011
Autor:
Marc D. Zack, Matthew P. Yates, Micky D. Tortorella, Melissa R. Radabaugh, Joseph W. Leone, Robert L. Hills, David W. Griggs, James T. Alston, Adam Skepner, Troii Hall, Anne-Marie Malfait, Elizabeth C. Arner, Olga V. Nemirovskiy
Publikováno v:
Arthritis & Rheumatism. 60:2704-2713
Objective Fibronectin fragments are thought to play a critical role in the initiation and progression of cartilage degradation in arthritis. In a recent study, fibronectin neoepitopes resulting from cleavage of intact fibronectin at the Ala271/Val272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba595df08bec6aa93b2f6f2b561a097
https://doi.org/10.1002/art.24753
https://doi.org/10.1002/art.24753
Publikováno v:
Journal of pharmaceutical sciences. 105(5)
Decreases in polysorbate (PS80) content were observed while evaluating the long-term storage stability of Chinese hamster ovary-derived, purified monoclonal antibodies. It was determined that polysorbate had been enzymatically degraded; therefore, st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffb1fe67ac469515766877cfb1d2c23
https://pubmed.ncbi.nlm.nih.gov/27056628
https://pubmed.ncbi.nlm.nih.gov/27056628
Autor:
Sumathy Mathialagan, Hymavathi Boddupalli, Q. Khai Huynh, Sharon Rouw, Gary Lange, Troii Hall, David Creely, Rodney G. Combs, Catherine S. Tripp, Ann M. Donnelly, Kuniko Kretzmer, Beverley Reitz, James Caroll, Nandini Kishore
Publikováno v:
Journal of Biological Chemistry. 277:13840-13847
NF-kappaB is sequestered in the cytoplasm by the inhibitory IkappaB proteins. Stimulation of cells by agonists leads to the rapid phosphorylation of IkappaBs leading to their degradation that results in NF-kappaB activation. IKK-1 and IKK-2 are two d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e2af8226f4a10b1f6807157139c867
https://doi.org/10.1074/jbc.m110474200
https://doi.org/10.1074/jbc.m110474200