Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Troels Bundgaard Jensen"'
Publikováno v:
Karlsen, K K, Jensen, T B & Wengel, J 2009, ' Synthesis of an unlocked nucleic acid terpyridine monomer and binding of divalent metal ion in nucleic acid duplexes ', Journal of Organic Chemistry, vol. 74, no. 22, pp. 8838-8841 . https://doi.org/10.1021/jo9019978
Herein we present the synthesis and thermal stability studies of modified oligonucleotides containing an unlocked nucleic acid (UNA) terpyridine monomer. Incorporation of this monomer into both strands of a DNA duplex allowed reversible thermal stabi
Publikováno v:
Madsen, A S, Jørgensen, A S, Jensen, T B & Wengel, J 2012, ' Large Scale Synthesis of 2'-Amino-LNA Thymine and 5-Methylcytosine Nucleosides ', Journal of Organic Chemistry, vol. 77, no. 23, pp. 10718-28 . https://doi.org/10.1021/jo302036h
Thymine intermediate 17 has been synthesized on a multigram scale (50 g, 70 mmol) from starting sugar 1 in 15 steps in an overall yield of 73%, with only 5 purification steps. The key thymine intermediate 18 was obtained from 17 in a single step in 9
Pyrene-modified unlocked nucleic acids: synthesis, thermodynamic studies, and fluorescent properties
Publikováno v:
Karlsen, K K, Pasternak, A, Jensen, T B & Wengel, J 2012, ' Pyrene-modified unlocked nucleic acids: synthesis, thermodynamic studies, and fluorescent properties ', ChemBioChem, vol. 13, no. 4, pp. 590-601 . https://doi.org/10.1002/cbic.201100689
Two pyrene-modified UNA monomers were synthesized and incorporated into 21-mer DNA oligonucleotides. Melting temperatures and thermodynamic properties of the modified duplexes were measured, and the fluorescence properties of single strands and duple
Autor:
Patrick J. Hrdlicka, Poul Nielsen, Rie L. Rathje, Troels Bundgaard Jensen, Brooke A. Anderson, Sanne Andersen, Saswata Karmakar
Publikováno v:
Karmakar, S, Anderson, B A, Rathje, R L, Andersen, S, Jensen, T B, Nielsen, P & Hrdlicka, P J 2011, ' High-affinity DNA-targeting using Readily Accessible Mimics of N2’-Functionalized 2’-Amino-α-L-LNA ', Journal of Organic Chemistry, vol. 76, pp. 7119-7131 . https://doi.org/10.1021/jo201095p
N2'-Pyrene-functionalized 2'-amino-α-L-LNAs (locked nucleic acids) display extraordinary affinity toward complementary DNA targets due to favorable preorganization of the pyrene moieties for hybridization-induced intercalation. Unfortunately, the sy
Autor:
Michael B. Petersen, Jesper Wengel, Anna Pasternak, Troels Bundgaard Jensen, Andreas Stahl Madsen
Publikováno v:
Bundgaard Jensen, T, Pasternak, A, Stahl Madsen, A, Petersen, M & Wengel, J 2011, ' Synthesis and Structural Characterization of 2'-Fluoro-α-L-RNA-Modified Oligonucleotides ', ChemBioChem, vol. 12, no. 12, pp. 1904-11 . https://doi.org/10.1002/cbic.201100161
We describe the synthesis and binding properties of oligonucleotides that contain one or more 2'-fluoro-α-L-RNA thymine monomer(s). Incorporation of 2'-fluoro-α-L-RNA thymine into oligodeoxynucleotides decreased thermal binding stability slightly u
Autor:
Troels Bundgaard Jensen, Anna Pasternak, Lars Melholt Rasmussen, Jesper Wengel, Jonas Rosager Henriksen, Bjarne E. Rasmussen, Thomas Lars Andresen
Publikováno v:
Jensen, T B, Henriksen, J R, Rasmussen, L B, Rasmussen, L M, Andresen, T L, Wengel, J & Pasternak, A 2011, ' Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 2'-C-piperazino-UNA monomer ', Bioorganic & Medicinal Chemistry, vol. 19, no. 16, pp. 4739-45 . https://doi.org/10.1016/j.bmc.2011.06.087
Thrombin binding aptamer is a DNA 15-mer which forms a G-quadruplex structure and possess promising anticoagulant properties due to specific interactions with thrombin. Herein we present the influence of a single 2'-C-piperazino-UNA residue and UNA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e9432b51a7c69b41c7fb04234d8a48
https://portal.findresearcher.sdu.dk/da/publications/eacc2e44-11b1-4d7f-b2af-467acadcc4b3
https://portal.findresearcher.sdu.dk/da/publications/eacc2e44-11b1-4d7f-b2af-467acadcc4b3
Publikováno v:
Scopus-Elsevier
A study on the thermal stability of duplexes formed between unlocked nucleic acid (UNA) modified DNA and RNA oligonucleotides and complementary DNA and RNA is presented. The acyclic UNA monomers are shown to induce a decrease in duplex thermal stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d644cfff8c39a466f8467504287a5202
http://www.scopus.com/inward/record.url?eid=2-s2.0-78649428611&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-78649428611&partnerID=MN8TOARS