Gut Microbiome-Modified Polyphenolic Compounds Inhibit α-Synuclein Seeding and Spreading in α-Synucleinopathies

Autor: Tritia R. Yamasaki, Kenjiro Ono, Lap Ho, Giulio M. Pasinetti

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Misfolding, aggregation and deposition of α-synuclein (α-syn) are major pathologic characteristics of Parkinson’s disease (PD) and the related synucleinopathy, multiple system atrophy (MSA). The spread of α-syn pathology across brain regions is

Externí odkaz: https://doaj.org/article/578cb155c9144b0fa34378301391497e

Visualization of the Movement Disorder Society Unified Parkinson’s Disease Rating Scale Results

Autor: Jaimie Hixson, Jorge E. Quintero, Ashley Guiliani, Tritia R. Yamasaki, Greg A. Gerhardt, John T. Slevin, Craig G. van Horne

Publikováno v: Journal of Parkinson's Disease. 13:421-426

We sought to design a data visualization platform to represent the Movement Disorder Society- Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) item scores in an easy-to-use display without modification of the raw data or summary scores. Score i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1e23c9ba75c8b33dcfd8e82899cbce3
https://doi.org/10.3233/jpd-225071

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

Autor: Joaquin A. Vizcarra, Michael A. Schwarzschild, George Perry, Keith A. Josephs, Caroline M. Tanner, Ignacio F. Mata, Rodolfo Savica, Ziv Gan-Or, Luca Marsili, Marcelo Andrés Kauffman, Tritia R. Yamasaki, S. Pablo Sardi, David Simon, Aristide Merola, James B. Leverenz, Anthony E. Lang, Patrik Brundin, Irene Litvan, Hubert H. Fernandez, Todd Sherer, David G. Standaert, J. Timothy Greenamyre, Alfonso Fasano, Alberto J. Espay, Cyrus P. Zabetian, Francesca Morgante, Franca Cambi

Publikováno v: Espay, Alberto J; Vizcarra, Joaquin A; Marsili, Luca; Lang, Anthony E; Simon, David K; Merola, Aristide; et al.(2019). Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.. Neurology, 92(7), 329-337. doi: 10.1212/wnl.0000000000006926. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6240z8z7
Neurology, vol 92, iss 7

The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles. Impl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b356502e2ca2854a565ff5098d980f
https://doi.org/10.1212/wnl.0000000000006926

Gait and Balance Changes with Investigational Peripheral Nerve Cell Therapy during Deep Brain Stimulation in People with Parkinson’s Disease

Autor: Anna Krotinger, John T. Slevin, Geetanjali Gera, Greg A. Gerhardt, Tritia R. Yamasaki, Craig G. van Horne, Monica Chau, Jorge E. Quintero, Zain Guduru, Julie A. Gurwell, Frederick A. Schmitt

Publikováno v: Brain Sciences
Brain Sciences, Vol 11, Iss 500, p 500 (2021)

Background: The efficacy of deep brain stimulation (DBS) and dopaminergic therapy is known to decrease over time. Hence, a new investigational approach combines implanting autologous injury-activated peripheral nerve grafts (APNG) at the time of bila

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287ea44a9e2193b29c7224688fda9b62
http://europepmc.org/articles/PMC8071359

DBS Plus: a clinical trial platform for combining delivery of investigational therapeutics with deep brain stimulation surgery in patients with parkinson’s disease

Autor: Tripp Hines, C. van Horne, John T. Slevin, Julie A. Gurwell, Lisa M. Koehl, Tritia R. Yamasaki, Jorge E. Quintero, Greg A. Gerhardt, Frederick A. Schmitt, Andrew Welleford, A. Granholm-Bentley, Zain Guduru

Publikováno v: Cytotherapy. 23:S125

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33db04bbb2886d2cddef9362345f9011
https://doi.org/10.1016/s1465324921004801