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Identification of pre-existing microbiome and metabolic vulnerabilities to escalation of oxycodone self-administration and identification of a causal role of short-chain fatty acids in addiction-like behaviors

Autor: Sierra Simpson, Adam Kimbrough, Gregory Peters, Emma Wellmeyer, Rio Mclellan, Natalie Walker, Haoyu Jia, Sharon Hu, Mohini Iyer, Varshini Sathish, Sharona Sedighim, Marsida Kallupi, Molly Brennan, Lisa Maturin, Talyn Hughes, Tristin Xie, Veronika Espinoza, Lieselot Carrette, Lauren C. Smith, Jonathan Seaman, Leah C. Solberg Woods, Abraham A. Palmer, Giordano DeGuglielmo, Olivier George

The gut brain axis is thought to play a role in behavior and physiological responses through chemical, immunological, and metabolite signaling. Antibiotics, diet, and drugs can alter the transit time of gut contents as well as the makeup of the micro

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