Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Tristan S Maurer"'
Autor:
Jangir Selimkhanov, W Clayton Thompson, Terrell A Patterson, John R Hadcock, Dennis O Scott, Tristan S Maurer, Cynthia J Musante
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155674 (2016)
The purpose of this work is to develop a mathematical model of energy balance and body weight regulation that can predict species-specific response to common pre-clinical interventions. To this end, we evaluate the ability of a previously published m
Externí odkaz:
https://doaj.org/article/b8265b1953804725b8d28146b34ee9e1
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/4d032b2f4a5340a1a1ca1152a8f435f8
Autor:
Irena Loryan, Andreas Reichel, Bo Feng, Christoffer Bundgaard, Christopher Shaffer, Cory Kalvass, Dallas Bednarczyk, Denise Morrison, Dominique Lesuisse, Edmund Hoppe, Georg C. Terstappen, Holger Fischer, Li Di, Nicola Colclough, Scott Summerfield, Stephen T. Buckley, Tristan S. Maurer, Markus Fridén
Publikováno v:
Pharmaceutical Research. 39:1321-1341
Purpose More than 15 years have passed since the first description of the unbound brain-to-plasma partition coefficient (Kp,uu,brain) by Prof. Margareta Hammarlund-Udenaes, which was enabled by advancements in experimental methodologies including cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450f3186fa63b212c77d3ed7977fbf35
https://doi.org/10.1007/s11095-022-03246-6
https://doi.org/10.1007/s11095-022-03246-6
Autor:
Christopher Keefer, Tristan S. Maurer, David A. Tess, Heather Eng, Anthony Carlo, Zhenhong Li, John Litchfield
Publikováno v:
Journal of Medicinal Chemistry. 63:6489-6498
Drug precipitation in the nephrons of the kidney can cause drug-induced crystal nephropathy (DICN). To aid mitigation of this risk in early drug discovery, we developed a physiologically based in silico model to predict DICN in rats, dogs, and humans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1317753305e0bc4b81f1263f1467df8
https://doi.org/10.1021/acs.jmedchem.9b01995
https://doi.org/10.1021/acs.jmedchem.9b01995
Autor:
David A, Tess, Tristan S, Maurer, Zhenhong, Li, Christine, Bulawa, James, Fleming, Amy T, Moody
Tafamidis inhibits progression of transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) by binding TTR tetramer and inhibiting dissociation to monomers capable of denaturation and deposition in cardiac tissue. While the phase 3 ATTR-ACT trial demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfc615598710bd8f22c71aacc171c96
Autor:
Tristan S. Maurer
Publikováno v:
Clinical Pharmacology & Therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d01d780ba578da22b748fcfd15a3793
https://doi.org/10.1002/cpt.2159
https://doi.org/10.1002/cpt.2159
Autor:
Patrick Robert Verhoest, David Hepworth, Tristan S. Maurer, Charlotte Moira Norfor Allerton, Martin Paul Edwards
Publikováno v:
Drug discovery today. 27(2)
Successful small-molecule drug design requires a molecular target with inherent therapeutic potential and a molecule with the right properties to unlock its potential. Present-day drug design strategies have evolved to leave little room for improveme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8390524276e222b24b7f53fa740fa2af
https://pubmed.ncbi.nlm.nih.gov/34601124
https://pubmed.ncbi.nlm.nih.gov/34601124
Autor:
Nandini Chaturbhai Patel, Jennifer L. Liras, Patrick Trapa, Mark A. West, Tristan S. Maurer, Bo Feng, Patrick Robert Verhoest, Simone Sciabola, Travis T. Wager, Xinjun Hou
Publikováno v:
ACS chemical neuroscience. 12(6)
One of the objectives within the medicinal chemistry discipline is to design tissue targeting molecules. The objective of tissue specificity can be either to gain drug access to the compartment of interest (e.g., the CNS) for Neuroscience targets or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62bdff50f4f1777f718bef119679853
https://pubmed.ncbi.nlm.nih.gov/33651587
https://pubmed.ncbi.nlm.nih.gov/33651587
Autor:
Atli, Thorarensen, Paul, Balbo, Mary E, Banker, Robert M, Czerwinski, Max, Kuhn, Tristan S, Maurer, Jean-Baptiste, Telliez, Fabien, Vincent, Arthur J, Wittwer
Publikováno v:
Bioorganicmedicinal chemistry. 29
Recent years have seen a resurgence in drug discovery efforts aimed at the identification of covalent inhibitors which has led to an explosion of literature reports in this area and most importantly new approved therapies. These reports and breakthro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56f2f6c0d2c58d96767fd02cd0a3598e
https://pubmed.ncbi.nlm.nih.gov/33285410
https://pubmed.ncbi.nlm.nih.gov/33285410
Autor:
Zhenhong, Li, John, Litchfield, David A, Tess, Anthony A, Carlo, Heather, Eng, Christopher, Keefer, Tristan S, Maurer
Publikováno v:
Journal of medicinal chemistry. 63(12)
Drug precipitation in the nephrons of the kidney can cause drug-induced crystal nephropathy (DICN). To aid mitigation of this risk in early drug discovery, we developed a physiologically based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::20607fb330951ed8126019440152b17d
https://pubmed.ncbi.nlm.nih.gov/32130005
https://pubmed.ncbi.nlm.nih.gov/32130005