Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Tristan Rousseaux"'
Autor:
Laurence Millet, Angelina Besse, Stéphanie Tissandié, Gernot Zech, Marie-Francoise Bordes, Alain Badorc, Lassalle Gilbert, Valerie Fossey, Jean-Pascal Herault, Frédérique Dol, Christophe Boldron, Benjamin Gau, Christophe Briot, Nathalie Delesque, Anne-Marie Pflieger, Françoise Bono, Xavier Yvon, Marc Nazaré, Guillaume Barre, Tristan Rousseaux, Jean-Marc Herbert, Sandrine Bonnet-Lignon, Jerome Meneyrol, Pierre Savi
Publikováno v:
Journal of medicinal chemistry. 57(17)
In the search of a potential backup for clopidogrel, we have initiated a HTS campaign designed to identify novel reversible P2Y12 antagonists. Starting from a hit with low micromolar binding activity, we report here the main steps of the optimization
Autor:
Christophe Briot, Paul J. Schaeffer, Jean-Michel Altenburger, Herman Schreuder, Tristan Rousseaux, Guillaume Barre, Lassalle Gilbert, Frédérique Dol, Laurence Millet, Jean-Marc Herbert, Jerome Meneyrol, Freddy Sadoun, Peter Florian, Frédéric Petit, Jean-Pascal Herault, Zsolt Böcskei, Volkmar Wehner, Markus Follmann, Françoise Bono, Nathalie Alet, Sylvie Klieber
Publikováno v:
Journal of medicinal chemistry. 56(23)
Compound 15 (SAR107375), a novel potent dual thrombin and factor Xa inhibitor resulted from a rational optimization process. Starting from compound 14, with low factor Xa and modest anti-thrombin inhibitory activities (IC50's of 3.5 and 0.39 μM, res