Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Tristan J. Tyler"'
Publikováno v:
Molecules, Vol 28, Iss 7, p 3189 (2023)
Bioactive peptides are a highly abundant and diverse group of molecules that exhibit a wide range of structural and functional variation. Despite their immense therapeutic potential, bioactive peptides have been traditionally perceived as poor drug c
Externí odkaz:
https://doaj.org/article/93a1f8c1e1b74194b60f70dbf34e4b99
Autor:
David J. Craik, Tristan J. Tyler
Publikováno v:
Total Chemical Synthesis of Proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cedc7983493e2b2d2d150b82e6effcf
https://doi.org/10.1002/9783527823567.ch21
https://doi.org/10.1002/9783527823567.ch21
Publikováno v:
Angewandte Chemie. 133:4050-4054
The use of enzymes for the site-specific modification of proteins/peptides has become a highly accessible, widespread approach to study protein/peptide functions or to generate therapeutic conjugates. Asparaginyl endopeptidases (AEPs) that preferenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a680ba6a243de1e150678c82d0710f8
https://doi.org/10.1002/ange.202013584
https://doi.org/10.1002/ange.202013584
Publikováno v:
Angewandte Chemie (International ed. in English). 61(11)
Transpeptidase-catalyzed protein and peptide modifications have been widely utilized for generating conjugates of interest for biological investigation or therapeutic applications. However, all known transpeptidases are constrained to ligating in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc558253885e1fcb380121e99490d08
https://pubmed.ncbi.nlm.nih.gov/35018698
https://pubmed.ncbi.nlm.nih.gov/35018698
Autor:
Tristan J. Tyler, Thomas Durek, David J. Craik, Simon J. de Veer, Kuok Yap, Fabian B. H. Rehm
Publikováno v:
Journal of the American Chemical Society. 143(46)
Chemoenzymatic protein and peptide modification is a powerful means of generating defined, homogeneous conjugates for a range of applications. However, the use of transpeptidases is limited by the need to prepare synthetic peptide conjugates to be li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a938ac1332a433043794856a9fc749ab
https://pubmed.ncbi.nlm.nih.gov/34761936
https://pubmed.ncbi.nlm.nih.gov/34761936