Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tristan J. Lubinski"'
Autor:
Shenghua Wen, Srividya B. Balachander, Francis D. Gibbons, Michael Zinda, William McCoull, Nancy Su, Barry R. Davies, Stephen E. Kurtz, Terry MacIntyre, Edward J. Hennessy, Martin Wild, Paula Lewis, Ricky W. Johnstone, Jamal Carlos Saeh, Kathleen A. Burke, Omid Tavana, Andrea Newbold, Elizabeth A. Coker, Alwin Schuller, Justin Cidado, Diebold R Bruce, Tristan J. Lubinski, Steven Criscione, J. Paul Secrist, Kate Byth, Gareth P. Gregory, Deborah Lawson, Ammar Adam, Shannon K. McWeeney, Stephen Fawell, Thomas Gero, Jeffrey G. Varnes, Eric Gangl, Patricia Jaaks, Jeffrey W. Tyner, Mathew J. Garnett, Areya Tabatabai, Stephanos Ioannidis
Publikováno v:
Clinical Cancer Research. 26:6535-6549
Purpose: Targeting Bcl-2 family members upregulated in multiple cancers has emerged as an important area of cancer therapeutics. While venetoclax, a Bcl-2–selective inhibitor, has had success in the clinic, another family member, Bcl-xL, has also e
Autor:
Barrett Nuttall, Brian Dougherty, Daniel Stetson, Tristan J. Lubinski, Justin Johnson, Xing Xu, J. Carl Barrett, Ambar Ahmed
Publikováno v:
JCO Precision Oncology. :1-9
PURPOSE Discordance between plasma and tumor variant calling has been attributed primarily to tumor heterogeneity, whereas technical variables remain largely unexplored. MATERIALS AND METHODS To measure these variables, we tested four next-generation
Autor:
Ambar Ahmed, Tristan J. Lubinski, J. Carl Barrett, Daniel Stetson, Brian Dougherty, Barrett Nuttall
Publikováno v:
Clinical Cancer Research. 26:A63-A63
Noninvasive circulating tumor DNA (ctDNA) assays have the potential to revolutionize clinical trial design; however, challenges still remain in using ctDNA for the molecular profiling of cancer with next-generation sequencing (NGS). Our previous work
Autor:
Francis S. Wolenski, John R. Finnerty, Derek J. Stefanik, Michael R. Garbati, Nikki Traylor-Knowles, Haley Goucher, Tristan J. Lubinski, Erica C. Dresselhaus, Thomas D. Gilmore
Publikováno v:
Molecular and Cellular Biology. 31:1076-1087
Under many circumstances, the NF-κB transcription factor signaling pathway is activated to enable animals to respond to environmental stresses, such as pathogens, chemicals, and UV light (14). Once activated, NF-κB transcription factors alter the e
Autor:
Rory Kirchner, Lara McGrath, Elizabeth Maloney, Tristan J. Lubinski, Daniel Stetson, J. Carl Barrett, Brian Dougherty
Publikováno v:
Cancer Research. 78:4582-4582
Introduction Understanding the tumor microenvironment is challenging in situations where a tumor biopsy is unavailable. In these situations, liquid biopsies provide a less invasive alternative that can be collected at multiple timepoints throughout t
Autor:
Tristan J. Lubinski, Fakhera Afshar, Brian Dougherty, Carl Barrett, Daniel Stetson, Barrett Nuttall, Ambar Ahmed, Amelia Raymond
Publikováno v:
Cancer Research. 78:LB-223
The increased reliance on liquid biopsy next generation sequencing assays for oncology clinical decisions has highlighted the importance of understanding the factors that impact the analytical validation and clinical utility of these tests. Although
Autor:
Barrett Nuttall, Ambar Ahmed, J. Carl Barrett, Aleksandra Markovets, Brian Dougherty, Robert McEwen, David Whitston, Gaia Schiavon, Tristan J. Lubinski, Kenneth S. Thress, Daniel Stetson
Publikováno v:
Cancer Research. 77:LB-249
The increased usage of circulating tumor DNA (ctDNA) sequencing for oncology clinical research demonstrates a critical need for sensitive and specific testing. While we have observed a high degree of concordance between single tumor mutations in tumo
Autor:
Allyson L. Byrd, Allison Lorenc, John R. Finnerty, Derek J. Stefanik, Lukas B. DeFilippo, Tristan J. Lubinski, Adam M. Reitzel, Brian R. Granger
Publikováno v:
BMC Genomics
Background The lined sea anemone Edwardsiella lineata is an informative model system for evolutionary-developmental studies of parasitism. In this species, it is possible to compare alternate developmental pathways leading from a larva to either a fr
Autor:
Sara Garamszegi, Yu Xia, Jarrod A. Marto, Tristan J. Lubinski, Les Kaufman, Nikki Traylor-Knowles, Jignesh R. Parikh, John R. Finnerty, Brian R. Granger
Publikováno v:
BMC Genomics, Vol 12, Iss 1, p 585 (2011)
BMC Genomics
BMC Genomics
Background Motivated by the precarious state of the world's coral reefs, there is currently a keen interest in coral transcriptomics. By identifying changes in coral gene expression that are triggered by particular environmental stressors, we can beg
Publikováno v:
Current genetics. 58(1)
While the counterselectable Schizosaccharomyces pombe ura4 + gene can be used to prepare a site in the S. pombe genome to receive an unmarked mutant allele (loss of ura4 + confers 5FOA-resistant (5FOAR) growth), the desired unmarked knock-in strains