Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Tristan J de Jesus"'
Autor:
Kenneth T Farabaugh, Dawid Krokowski, Bo-Jhih Guan, Zhaofeng Gao, Xing-Huang Gao, Jing Wu, Raul Jobava, Greeshma Ray, Tristan J de Jesus, Massimiliano G Bianchi, Evelyn Chukwurah, Ovidio Bussolati, Michael Kilberg, David A Buchner, Ganes C Sen, Calvin Cotton, Christine McDonald, Michelle Longworth, Parameswaran Ramakrishnan, Maria Hatzoglou
Publikováno v:
eLife, Vol 9 (2020)
The inability of cells to adapt to increased environmental tonicity can lead to inflammatory gene expression and pathogenesis. The Rel family of transcription factors TonEBP and NF-κB p65 play critical roles in the switch from osmoadaptive homeostas
Externí odkaz:
https://doaj.org/article/bfbaa90f7d4c41fb9bf0e7ea7e264f23
Autor:
Angela Rose Liu, Nandini Sarkar, Jordan D. Cress, Tristan J. de Jesus, Ananya Vadlakonda, Joshua T. Centore, Alexis D. Griffith, Bethany Rohr, Thomas S. McCormick, Kevin D. Cooper, Parameswaran Ramakrishnan
Publikováno v:
EBioMedicine, Vol 110, Iss , Pp 105452- (2024)
Summary: Background: Nuclear factor kappa B (NF-κB) c-Rel is a psoriasis susceptibility locus, however mechanisms underlying c-Rel transactivation during disease are poorly understood. Inflammation in psoriasis can be triggered following Toll-like R
Externí odkaz:
https://doaj.org/article/50d8c9876c9a43f7bbc4b068aa7dd51a
Autor:
Tristan J de Jesus, Angela R Liu, Parameswaran Ramakrishnan, Franklin D Staback Rodriguez, Joshua Centore, Ruchira A Agarwal, Timothy S. Kern, Jeffrey Tomalka
Publikováno v:
Glycobiology, vol 31, iss 7
Glycobiology
Glycobiology
O-GlcNAcylation is a reversible post-translational protein modification that regulates fundamental cellular processes including immune responses and autoimmunity. Previously, we showed that hyperglycemia increases O-GlcNAcylation of the transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec215eae60c0099a88ec1a17805ba8cc
https://escholarship.org/uc/item/4wh8q17t
https://escholarship.org/uc/item/4wh8q17t
Publikováno v:
Diabetes. 69
The NF-kappaB protein c-Rel is essential for the expression of forkhead box P3 (FOXP3), the master transcription factor that governs development and function of T regulatory cells. We found that O-GlcNAcylation of c-Rel at serine residue 350 suppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63620796f24adfebbee0d6ab04c919da
https://doi.org/10.2337/db20-1668-p
https://doi.org/10.2337/db20-1668-p
Autor:
Zhaofeng Gao, Dawid Krokowski, Christine McDonald, Tristan J de Jesus, Xing-Huang Gao, David A. Buchner, Ganes C. Sen, Raul Jobava, Evelyn Chukwurah, Greeshma Ray, Calvin U. Cotton, Kenneth T. Farabaugh, Parameswaran Ramakrishnan, Bo-Jhih Guan, Michael S. Kilberg, Maria Hatzoglou, Jing Wu, Ovidio Bussolati, Massimiliano G. Bianchi, Michelle Suzanne Longworth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::153bdcc7d1b708b5151f9c1e7ff6a5e1
https://doi.org/10.7554/elife.52241.sa2
https://doi.org/10.7554/elife.52241.sa2
Publikováno v:
Cellular Immunology. 333:85-92
O-linked β-N-acetyl glucosamine modification (O-GlcNAcylation) is a dynamic, reversible posttranslational modification of cytoplasmic and nuclear proteins. O-GlcNAcylation depends on nutrient availability and the hexosamine biosynthetic pathway (HBP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1b674ccb0b22be2efbfb5293916baa
https://doi.org/10.1016/j.cellimm.2018.05.010
https://doi.org/10.1016/j.cellimm.2018.05.010
Autor:
Tristan J de Jesus, Calvin U. Cotton, Maria Hatzoglou, Zhaofeng Gao, Michael S. Kilberg, Massimiliano G. Bianchi, Xing-Huang Gao, David A. Buchner, Jing Wu, Ovidio Bussolati, Bo-Jhih Guan, Ganes C. Sen, Raul Jobava, Evelyn Chukwurah, Greeshma Ray, Christine McDonald, Kenneth T. Farabaugh, Dawid Krokowski, Michelle Suzanne Longworth, Parameswaran Ramakrishnan
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
The inability of cells to adapt to increased environmental tonicity can lead to inflammatory gene expression and pathogenesis. The Rel family of transcription factors TonEBP and NF-κB p65 play critical roles in the switch from osmoadaptive homeostas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c6c2957b8ba510c6d402072505f8fb
https://pubmed.ncbi.nlm.nih.gov/32175843
https://pubmed.ncbi.nlm.nih.gov/32175843
Publikováno v:
Diabetes. 68
Type 1 diabetes is an autoimmune disease associated with hyperglycemia. Increased glucose flux enhances the hexosamine biosynthetic pathway and intracellular posttranslational modification of proteins by the sugar N-acetyl glucosamine (GlcNAc) in a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be68530d7eb3bae881c30bba520cf1d5
https://doi.org/10.2337/db19-1176-p
https://doi.org/10.2337/db19-1176-p
Publikováno v:
Cellular and Molecular Immunology
Recognition of pathogens by Toll-like receptors (TLR) activate multiple signaling cascades and expression of genes tailored to mount a primary immune response, inflammation, cell survival and apoptosis. Although TLR-induced activation of pathways, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080b78c55e3934cbbeeeb94b27d6d978
https://doi.org/10.1038/cmi.2016.32
https://doi.org/10.1038/cmi.2016.32
Autor:
Tristan J de Jesus, Jeffery Tomalka, Sudhanshu Shukla, Franklin Staback, Ruchira Agarwal, Joshua Centore, Parameswaran Ramakrishnan
Publikováno v:
The Journal of Immunology. 202:116.15-116.15
The NF-kappaB protein c-Rel plays a critical role in controlling autoimmunity through regulating T cell function and T regulatory cell development. Type 1 diabetes is a T cell-mediated autoimmune disease associated with hyperglycemia and chronic infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd94a9c2638ca966fd3f20e36c46afb3
https://doi.org/10.4049/jimmunol.202.supp.116.15
https://doi.org/10.4049/jimmunol.202.supp.116.15