Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Tristan FRUM"'
Autor:
Tristan Frum, Peggy P. Hsu, Renee F. C. Hein, Ansley S. Conchola, Charles J. Zhang, Olivia R. Utter, Abhinav Anand, Yi Zhang, Sydney G. Clark, Ian Glass, Jonathan Z. Sexton, Jason R. Spence
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-19 (2023)
Abstract Alveolar type 2 (AT2) cells function as stem cells in the adult lung and aid in repair after injury. The current study aimed to understand the signaling events that control differentiation of this therapeutically relevant cell type during hu
Externí odkaz:
https://doaj.org/article/5ca897a5633c4b8a87c9e8f808121ad2
Autor:
Bradford W Daigneault, Marcela Vilarino, Sandeep K Rajput, Tristan Frum, George W Smith, Pablo J Ross
Publikováno v:
BioTechniques, Vol 65, Iss 5, Pp 281-283 (2018)
CRISPR technologies used for mammalian embryology have wide implications from basic research to applications in agriculture and biomedicine. Confirmation of successful gene editing following CRISPR/Cas9 delivery is often limited to either protein exp
Externí odkaz:
https://doaj.org/article/6fb30c05086b486cb58e16d06a7bd51c
Publikováno v:
eLife, Vol 7 (2018)
During mammalian development, the challenge for the embryo is to override intrinsic cellular plasticity to drive cells to distinct fates. Here, we unveil novel roles for the HIPPO signaling pathway in controlling cell positioning and expression of So
Externí odkaz:
https://doaj.org/article/d5fa56eaab5e4c5782b7bd75d977e6b1
Autor:
Eryn Wicklow, Stephanie Blij, Tristan Frum, Yoshikazu Hirate, Richard A Lang, Hiroshi Sasaki, Amy Ralston
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004618 (2014)
Pluripotent epiblast (EPI) cells, present in the inner cell mass (ICM) of the mouse blastocyst, are progenitors of both embryonic stem (ES) cells and the fetus. Discovering how pluripotency genes regulate cell fate decisions in the blastocyst provide
Externí odkaz:
https://doaj.org/article/65e842a109774c90a28b1b9a660b66d8
Autor:
Renee F. C. Hein, Ansley S. Conchola, Alexis S. Fine, Zhiwei Xiao, Tristan Frum, Lindy K. Brastrom, Mayowa A. Akinwale, Charlie J. Childs, Yu-Hwai Tsai, Emily M. Holloway, Sha Huang, John Mahoney, Idse Heemskerk, Jason R. Spence
Publikováno v:
Development. 149
Bud tip progenitors (BTPs) in the developing lung give rise to all epithelial cell types found in the airways and alveoli. This work aimed to develop an iPSC organoid model enriched with NKX2-1+ BTP-like cells. Building on previous studies, we optimi
Autor:
Ansley S. Conchola, Tristan Frum, Zhiwei Xiao, Peggy P. Hsu, Renee F.C. Hein, Alyssa Miller, Yu-Hwai Tsai, Angeline Wu, Kamika Kaur, Emily M. Holloway, Abhinav Anand, Preetish K. L. Murthy, Ian Glass, Purushothama R. Tata, Jason R. Spence
Recent advances using single cell genomic approaches have identified new epithelial cell types and uncovered cellular heterogeneity in the murine and human lung (1). Here, using scRNA-seq and microscopy we identify and describe a secretory-like cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e037f265c82ad85dc07220adcff7cf3
https://doi.org/10.1101/2022.06.13.495813
https://doi.org/10.1101/2022.06.13.495813
Autor:
Renee F.C. Hein, Ansley S. Conchola, Alexis Fine, Zhiwei Xiao, Tristan Frum, Charlie J. Childs, Yu-Hwai Tsai, Emily M. Holloway, Sha Huang, John Mahoney, Jason R. Spence
Bud tip progenitors (BTPs) in the developing lung give rise to all epithelial cell types found in the airways and alveoli. The current work aimed to develop an iPSC organoid model enriched with stable NKX2-1+ BTP-like cells. Building on prior work, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68ab1ee13a6fae377908f0fb2927dca2
https://doi.org/10.1101/2022.02.25.481981
https://doi.org/10.1101/2022.02.25.481981
Autor:
Jason R. Spence, Tristan Frum
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Organoids derived from human pluripotent stem cells (hPSCs) have emerged as important models for investigating human-specific aspects of development and disease. Here we discuss hPSC-derived organoids through the lens of development—highlighting ho
Autor:
Lijia Li, Fangnong Lai, Xiaoyu Hu, Bofeng Liu, Xukun Lu, Zili Lin, Ling Liu, Yunlong Xiang, Tristan Frum, Michael Halbisen, Fengling Chen, Qiang Fan, Amy Ralston, Wei Xie
Publikováno v:
SSRN Electronic Journal.
Autor:
Renee F.C. Hein, Joshua H. Wu, Emily M. Holloway, Tristan Frum, Ansley S. Conchola, Yu-Hwai Tsai, Angeline Wu, Alexis S. Fine, Alyssa J. Miller, Emmanuelle Szenker-Ravi, Kelley S. Yan, Calvin J. Kuo, Ian Glass, Bruno Reversade, Jason R. Spence
Publikováno v:
Developmental Cell
The human respiratory epithelium is derived from a progenitor cell in the distal buds of the developing lung. These ""bud tip progenitors'' are regulated by reciprocal signaling with surrounding mesenchyme; however, mesenchymal heterogeneity and func