Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Tristan A. Scott"'
Autor:
Tristan A. Scott, Aroon Supramaniam, Adi Idris, Angelo A. Cardoso, Surya Shrivastava, Gabrielle Kelly, Nicole A. Grepo, Citradewi Soemardy, Roslyn M. Ray, Nigel A.J. McMillan, Kevin V. Morris
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 355-366 (2022)
SARS-CoV-2 (CoV-2) viral infection results in COVID-19 disease, which has caused significant morbidity and mortality worldwide. A vaccine is crucial to curtail the spread of SARS-CoV-2, while therapeutics will be required to treat ongoing and reemerg
Externí odkaz:
https://doaj.org/article/e0be4145231641698c313c54ca4c5a8c
Autor:
Surya Shrivastava, Roslyn M. Ray, Leo Holguin, Lilliana Echavarria, Nicole Grepo, Tristan A. Scott, John Burnett, Kevin V. Morris
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
A strategy to control HIV-1 infection is to stably repress HIV-1 and induce “deep latency”. Here the authors show that a recombinant anti-HIV-1-1 protein can be packaged as mRNA into exosomes and delivered systemically to repress HIV-1-1 within t
Externí odkaz:
https://doaj.org/article/c2f5bfdbc83d4fcc98387b48cc1d19d1
Autor:
Tristan A. Scott, Denis O’Meally, Nicole Anne Grepo, Citradewi Soemardy, Daniel C. Lazar, Yue Zheng, Marc S. Weinberg, Vicente Planelles, Kevin V. Morris
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 18-29 (2021)
Human immunodeficiency virus type 1 (HIV-1) causes a persistent viral infection resulting in the demise of immune regulatory cells. Clearance of HIV-1 infection results in integration of proviral DNA into the genome of host cells, which provides a me
Externí odkaz:
https://doaj.org/article/1f554cb5e02940e1a1a103dbbd42a73a
Autor:
Tristan A. Scott, Kevin V. Morris
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Viral oncogenic transformation of healthy cells into a malignant state is a well-established phenomenon but took decades from the discovery of tumor-associated viruses to their accepted and established roles in oncogenesis. Viruses cause ~ 1
Externí odkaz:
https://doaj.org/article/f24d799388b84416b39844fca025919a
Autor:
Daniel O. Pinto, Tristan A. Scott, Catherine DeMarino, Michelle L. Pleet, Thy T. Vo, Mohammed Saifuddin, Dmytro Kovalskyy, James Erickson, Maria Cowen, Robert A. Barclay, Chen Zeng, Marc S. Weinberg, Fatah Kashanchi
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-17 (2019)
Abstract Background HIV-1 patients receiving combination antiretroviral therapy (cART) survive infection but require life-long adherence at high expense. In chronic cART-treated patients with undetectable viral titers, cell-associated viral RNA is st
Externí odkaz:
https://doaj.org/article/a041f36c688d441cbb365e5ac91b9eeb
Autor:
Tiina Nieminen, Tristan A. Scott, Feng-Mao Lin, Zhen Chen, Seppo Yla-Herttuala, Kevin V. Morris
Publikováno v:
Non-Coding RNA, Vol 4, Iss 4, p 34 (2018)
The role and function of long non-coding RNAs (lncRNAs) in modulating gene expression is becoming apparent. Vascular endothelial growth factor A (VEGF-A) is a key regulator of blood vessel formation and maintenance making it a promising therapeutic t
Externí odkaz:
https://doaj.org/article/cb327e31f6f74c74a27ce7c415678504
Publikováno v:
Cancer Gene Therapy. 29:1477-1486
One of the greatest challenges in the treatment of cancer is tumor heterogeneity which results in differential responses to chemotherapy and drugs that work through a single pathway. A therapeutic agent that targets cancer cells for death through mul
Publikováno v:
NAR Cancer. 5
Human T-lymphotropic virus type I (HTLV-I) infects CD4+ T-cells resulting in a latent, life-long infection in patients. Crosstalk between oncogenic viral factors results in the transformation of the host cell into an aggressive cancer, adult T-cell l
Autor:
Laura Lim, Ryan Urak, Citradewi Soemardy, Shirley Li, Roslyn M. Ray, Galina Shevchenko, Xiuli Wang, Kevin V. Morris, Tristan A. Scott
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 285-294 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Human immunodeficiency virus (HIV) is an attractive target for chimeric antigen receptor (CAR) therapy. CAR T cells have proved remarkably potent in targeted killing of cancer cells, and we surmised that CAR T cells could prove useful in eradicating
Autor:
Denis O’Meally, Tristan A. Scott, Vicente Planelles, Yue Zheng, Marc S. Weinberg, Kevin V. Morris, Citradewi Soemardy, Nicole Grepo, Daniel C. Lazar
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 18-29 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 18-29 (2021)
Human immunodeficiency virus type 1 (HIV-1) causes a persistent viral infection resulting in the demise of immune regulatory cells. Clearance of HIV-1 infection results in integration of proviral DNA into the genome of host cells, which provides a me