Výsledky vyhledávání - "Trista L. Thorn"

Akademický článek

Interleukin-1β Protects Neurons against Oxidant-Induced Injury via the Promotion of Astrocyte Glutathione Production

Autor: Twinkle Chowdhury, Matthew F. Allen, Trista L. Thorn, Yan He, Sandra J. Hewett

Publikováno v: Antioxidants, Vol 7, Iss 8, p 100 (2018)

Interleukin-1β (IL-1β), a key cytokine that drives neuroinflammation in the Central Nervous System (CNS), is enhanced in many neurological diseases/disorders. Although IL-1β contributes to and/or sustains pathophysiological processes in the CNS, w

Externí odkaz: https://doaj.org/article/1f6f70bc191b4542b00e91289273a20c

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Akademický článek

A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System x Mediates Aglycemic Neuronal Cell Death

Autor: Trista L. Thorn, Yan He, Nicole A. Jackman, Doug Lobner, James A. Hewett, Sandra J. Hewett

Publikováno v: ASN Neuro, Vol 7 (2015)

The astrocyte cystine/glutamate antiporter (system x c − ) contributes substantially to the excitotoxic neuronal cell death facilitated by glucose deprivation. The purpose of this study was to determine the mechanism by which this occurred. Using p

Externí odkaz: https://doaj.org/article/0af5ee3359c240bb910e56410531664c

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Intestine-specific deletion of metal transporter Zip14 (Slc39a14) causes brain manganese overload and locomotor defects of manganism

Autor: Tolunay Beker Aydemir, Marcelo Febo, Trista L. Thorn, Robert Cousins, Courtney H. Ruggiero, Marjory Pompilus

Publikováno v: Am J Physiol Gastrointest Liver Physiol

Impaired manganese (Mn) homeostasis can result in excess Mn accumulation in specific brain regions and neuropathology. Maintaining Mn homeostasis and detoxification is dependent on effective Mn elimination. Specific metal transporters control Mn home

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b544af5945e38df2b246a63c1f4c73

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Interleukin-1β Protects Neurons against Oxidant-Induced Injury via the Promotion of Astrocyte Glutathione Production

Autor: Sandra J. Hewett, Twinkle Chowdhury, Matthew F Allen, Trista L. Thorn, Yan He

Publikováno v: Antioxidants, Vol 7, Iss 8, p 100 (2018)
Antioxidants
Volume 7
Issue 8

Interleukin-1&beta
(IL-1&beta
), a key cytokine that drives neuroinflammation in the Central Nervous System (CNS), is enhanced in many neurological diseases/disorders. Although IL-1&beta
contributes to and/or sustains pathophysiologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6b483bb840950861a5c8a7735d18a4
http://www.mdpi.com/2076-3921/7/8/100

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Interleukin-1β protects astrocytes against oxidant-induced injury via an NF-κB-Dependent upregulation of glutathione synthesis

Autor: Trista L. Thorn, Valarie E. Vought, Sandra J. Hewett, Nicole A. Jackman, Yan He

Publikováno v: Glia. 63:1568-1580

Astrocytes produce and export the antioxidant glutathione (GSH). Previously, we found that interleukin-1β (IL-1β) enhanced the expression of astrocyte system xc (-) , the transporter that delivers the rate-limiting substrate for GSH synthesis-cyst(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae1ad832fd41f23ddf50795b298d4bc3
https://doi.org/10.1002/glia.22828

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Biochemical and biophysical changes underlie the mechanisms of basement membrane disruptions in a mouse model of dystroglycanopathy

Autor: Trista L. Thorn, Yuan Yang, Noel W. Gray, Huaiyu Hu, Joseph Candiello, Peng Zhang, Willi Halfter

Publikováno v: Matrix Biology. 32:196-207

Mutations in glycosyltransferases, such as protein O-mannose N-acetylglucosaminyltransferase 1 (POMGnT1), causes disruptions of basement membranes (BMs) that results in neuronal ectopias and muscular dystrophy. While the mutations diminish dystroglyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c6f3a874657f85399272da1768e29e
https://doi.org/10.1016/j.matbio.2013.02.002

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A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System xc- Mediates Aglycemic Neuronal Cell Death

Autor: Nicole A. Jackman, James A. Hewett, Trista L. Thorn, Yan He, Sandra J. Hewett, Doug Lobner

Publikováno v: ASN NEURO
ASN Neuro, Vol 7 (2015)

The astrocyte cystine/glutamate antiporter (system xc−) contributes substantially to the excitotoxic neuronal cell death facilitated by glucose deprivation. The purpose of this study was to determine the mechanism by which this occurred. Using pure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c60ad590bee79251f52372ac0a98c2d
https://pubmed.ncbi.nlm.nih.gov/26553727

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Interleukin-1β protects astrocytes against oxidant-induced injury via an NF-κB-dependent upregulation of glutathione synthesis

Autor: Yan, He, Nicole A, Jackman, Trista L, Thorn, Valarie E, Vought, Sandra J, Hewett

Publikováno v: Glia. 63(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d34994d46e0800a1bfb69545497584dd
https://pubmed.ncbi.nlm.nih.gov/25880604

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