Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic

Autor: Trist, BG, Hilton, JB, Hare, DJ, Crouch, PJ, Double, KL

Cu/Zn superoxide dismutase (SOD1) is a frontline antioxidant enzyme catalysing superoxide breakdown and is important for most forms of eukaryotic life. The evolution of aerobic respiration by mitochondria increased cellular production of superoxide,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::8186086eca3531b1d575b20c4bd642ce
https://hdl.handle.net/10453/154476

Novel tools to quantify total, phospho-Ser129 and aggregated alpha-synuclein in the mouse brain.

Autor: Trist BG; Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia. benjamin.trist@sydney.edu.au.; Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia. benjamin.trist@sydney.edu.au., Wright CJ; Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.; Brain Repair and Imaging in Neural Systems (BRAINS), Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden., Rangel A; Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.; Melanoma Institute Australia, Sydney, NSW, Australia., Cottle L; Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia., Prasad A; Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia., Jensen NM; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, Aarhus, Denmark., Gram H; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, Aarhus, Denmark., Dzamko N; Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia., Jensen PH; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Danish Research Institute of Translational Neuroscience - DANDRITE, Aarhus University, Aarhus, Denmark., Kirik D; Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, Australia.; Brain Repair and Imaging in Neural Systems (BRAINS), Department of Experimental Medical Science, Faculty of Medicine, Lund University, Lund, Sweden.

Publikováno v: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2024 Nov 08; Vol. 10 (1), pp. 217. Date of Electronic Publication: 2024 Nov 08.

Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord.

Autor: Trist BG; Brain and Mind Centre and School of Medical Sciences (Neuroscience), Faculty of Medicine and Health, The University of Sydney, Sydney 2006, Australia., Genoud S; Brain and Mind Centre and School of Medical Sciences (Neuroscience), Faculty of Medicine and Health, The University of Sydney, Sydney 2006, Australia., Roudeau S; University Bordeaux, CNRS, CENBG, UMR 5797, F-33170 Gradignan, France., Rookyard A; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney 2006, Australia., Abdeen A; Brain and Mind Centre and School of Medical Sciences (Neuroscience), Faculty of Medicine and Health, The University of Sydney, Sydney 2006, Australia., Cottam V; Brain and Mind Centre and School of Medical Sciences (Neuroscience), Faculty of Medicine and Health, The University of Sydney, Sydney 2006, Australia., Hare DJ; School of Biosciences, The University of Melbourne, Parkville 3010, Australia.; Atomic Medicine Initiative, University of Technology Sydney, Broadway 2007, Australia., White M; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney 2006, Australia., Altvater J; Sydney Mass Spectrometry, The University of Sydney, Sydney 2006, Australia., Fifita JA; Centre for Motor Neuron Disease Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia., Hogan A; Centre for Motor Neuron Disease Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia., Grima N; Centre for Motor Neuron Disease Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia., Blair IP; Centre for Motor Neuron Disease Research, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia., Kysenius K; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville 3010, Australia., Crouch PJ; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville 3010, Australia., Carmona A; University Bordeaux, CNRS, CENBG, UMR 5797, F-33170 Gradignan, France., Rufin Y; Plateforme Biochimie, University of Bordeaux, Bordeaux, France., Claverol S; Plateforme Protéome, University of Bordeaux, Bordeaux, France., Van Malderen S; Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607 Hamburg, Germany., Falkenberg G; Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607 Hamburg, Germany., Paterson DJ; Australian Synchrotron, ANSTO, Clayton 3168, Australia., Smith B; Maurice Wohl Clinical Neuroscience Institute and the Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RT London, UK., Troakes C; UK Dementia Research Institute at King's College London, London SE5 9RT, UK., Vance C; Maurice Wohl Clinical Neuroscience Institute and the Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 9RT London, UK., Shaw CE; UK Dementia Research Institute at King's College London, London SE5 9RT, UK., Al-Sarraj S; London Neurodegenerative Diseases Brain Bank, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, SE5 8AF London, UK., Cordwell S; School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney 2006, Australia., Halliday G; Brain and Mind Centre and School of Medical Sciences (Neuroscience), Faculty of Medicine and Health, The University of Sydney, Sydney 2006, Australia., Ortega R; University Bordeaux, CNRS, CENBG, UMR 5797, F-33170 Gradignan, France., Double KL; Brain and Mind Centre and School of Medical Sciences (Neuroscience), Faculty of Medicine and Health, The University of Sydney, Sydney 2006, Australia.

Publikováno v: Brain : a journal of neurology [Brain] 2022 Sep 14; Vol. 145 (9), pp. 3108-3130.

Empirical evidence for biometal dysregulation in Parkinson's disease from a systematic review and Bradford Hill analysis.

Autor: Abdeen AH; Brain and Mind Centre and School of Medical Sciences (Neuroscience), Faculty of Medicine and Health, The University of Sydney, Camperdown, Sydney, NSW, 2050, Australia., Trist BG; Brain and Mind Centre and School of Medical Sciences (Neuroscience), Faculty of Medicine and Health, The University of Sydney, Camperdown, Sydney, NSW, 2050, Australia., Double KL; Brain and Mind Centre and School of Medical Sciences (Neuroscience), Faculty of Medicine and Health, The University of Sydney, Camperdown, Sydney, NSW, 2050, Australia. kay.double@sydney.edu.au.

Publikováno v: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2022 Jun 27; Vol. 8 (1), pp. 83. Date of Electronic Publication: 2022 Jun 27.

Superoxide Dismutase 1 in Health and Disease: How a Frontline Antioxidant Becomes Neurotoxic.

Autor: Trist BG; Brain and Mind Centre and Discipline of Pharmacology, The University of Sydney, Camperdown, Sydney, New South Wales, 2050, Australia., Hilton JB; Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, 3052, Australia., Hare DJ; Brain and Mind Centre and Discipline of Pharmacology, The University of Sydney, Camperdown, Sydney, New South Wales, 2050, Australia.; School of BioSciences, The University of Melbourne, Parkville, Victoria, 3052, Australia.; Atomic Medicine Initiative, The University of Technology Sydney, Broadway, New South Wales, 2007, Australia., Crouch PJ; Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, 3052, Australia., Double KL; Brain and Mind Centre and Discipline of Pharmacology, The University of Sydney, Camperdown, Sydney, New South Wales, 2050, Australia.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Apr 19; Vol. 60 (17), pp. 9215-9246. Date of Electronic Publication: 2020 Nov 19.