Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Trisha N Davis"'
CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation
Autor:
Axel F Brilot, Andrew S Lyon, Alex Zelter, Shruthi Viswanath, Alison Maxwell, Michael J MacCoss, Eric G Muller, Andrej Sali, Trisha N Davis, David A Agard
Publikováno v:
eLife, Vol 10 (2021)
Microtubule (MT) nucleation is regulated by the γ-tubulin ring complex (γTuRC), conserved from yeast to humans. In Saccharomyces cerevisiae, γTuRC is composed of seven identical γ-tubulin small complex (γTuSC) sub-assemblies, which associate hel
Externí odkaz:
https://doaj.org/article/d01c66d5a03743a7bf70f392cb7c8a89
Autor:
Grace E Hamilton, Luke A Helgeson, Cameron L Noland, Charles L Asbury, Yoana N Dimitrova, Trisha N Davis
Publikováno v:
eLife, Vol 9 (2020)
Partitioning duplicated chromosomes equally between daughter cells is a microtubule-mediated process essential to eukaryotic life. A multi-protein machine, the kinetochore, drives chromosome segregation by coupling the chromosomes to dynamic microtub
Externí odkaz:
https://doaj.org/article/832496a2e804424d87487e54736748fa
Autor:
Matthew P Miller, Rena K Evans, Alex Zelter, Elisabeth A Geyer, Michael J MacCoss, Luke M Rice, Trisha N Davis, Charles L Asbury, Sue Biggins
Publikováno v:
PLoS Genetics, Vol 15, Iss 10, p e1008423 (2019)
Accurate segregation of chromosomes to daughter cells is a critical aspect of cell division. It requires the kinetochores on duplicated chromosomes to biorient, attaching to microtubules from opposite poles of the cell. Bioriented attachments come un
Externí odkaz:
https://doaj.org/article/57ed7cbe60a946b1820b321a2a777c91
Publikováno v:
eLife, Vol 8 (2019)
Regulation of the outer kinetochore complex Ndc80 is essential to ensure correct kinetochore-microtubule attachments during mitosis. Here, we present a novel mechanism of regulation that is intrinsic to its structure; tight bending of the Ndc80 compl
Externí odkaz:
https://doaj.org/article/22548cf8af974371b5add468e7389c1b
Autor:
Jae ook Kim, Alex Zelter, Neil T Umbreit, Athena Bollozos, Michael Riffle, Richard Johnson, Michael J MacCoss, Charles L Asbury, Trisha N Davis
Publikováno v:
eLife, Vol 6 (2017)
Strong kinetochore-microtubule attachments are essential for faithful segregation of sister chromatids during mitosis. The Dam1 and Ndc80 complexes are the main microtubule binding components of the Saccharomyces cerevisiae kinetochore. Cooperation b
Externí odkaz:
https://doaj.org/article/5f0cbcb043664709adff91b73532d04c
Autor:
Stephanie Berger, Erik Procko, Daciana Margineantu, Erinna F Lee, Betty W Shen, Alex Zelter, Daniel-Adriano Silva, Kusum Chawla, Marco J Herold, Jean-Marc Garnier, Richard Johnson, Michael J MacCoss, Guillaume Lessene, Trisha N Davis, Patrick S Stayton, Barry L Stoddard, W Douglas Fairlie, David M Hockenbery, David Baker
Publikováno v:
eLife, Vol 5 (2016)
Many cancers overexpress one or more of the six human pro-survival BCL2 family proteins to evade apoptosis. To determine which BCL2 protein or proteins block apoptosis in different cancers, we computationally designed three-helix bundle protein inhib
Externí odkaz:
https://doaj.org/article/da3cabaf1a264379bba52814db23e987
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15426 (2010)
The Saccharomyces cerevisiae centrosome or spindle pole body (SPB) is a dynamic structure that is remodeled in a cell cycle dependent manner. The SPB increases in size late in the cell cycle and during most cell cycle arrests and exchanges components
Externí odkaz:
https://doaj.org/article/cfdcfaa35e57453782881689098fa2fa
Autor:
Lars Malmström, Michael Riffle, Charlie E M Strauss, Dylan Chivian, Trisha N Davis, Richard Bonneau, David Baker
Publikováno v:
PLoS Biology, Vol 5, Iss 4, p e76 (2007)
Saccharomyces cerevisiae is one of the best-studied model organisms, yet the three-dimensional structure and molecular function of many yeast proteins remain unknown. Yeast proteins were parsed into 14,934 domains, and those lacking sequence similari
Externí odkaz:
https://doaj.org/article/3d2903ae1917477193ee6bb42bfab50a
Autor:
Michael R. Hoopmann, David D. Shteynberg, Alex Zelter, Michael Riffle, Andrew S. Lyon, David A. Agard, Qing Luan, Brad J. Nolen, Michael J. MacCoss, Trisha N. Davis, Robert L. Moritz
Publikováno v:
Journal of Proteome Research. 22:647-655
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecaadf997bac307fb8bc70bce06c5af7
https://doi.org/10.1021/acs.jproteome.2c00670
https://doi.org/10.1021/acs.jproteome.2c00670
Autor:
Michael Riffle, Michael R. Hoopmann, Daniel Jaschob, Guo Zhong, Robert L. Moritz, Michael J. MacCoss, Trisha N. Davis, Nina Isoherranen, Alex Zelter
Publikováno v:
Analytical Chemistry. 94:3501-3509
Drugs are often metabolized to reactive intermediates that form protein adducts. Adducts can inhibit protein activity, elicit immune responses, and cause life-threatening adverse drug reactions. The masses of reactive metabolites are frequently unkno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4e26e0e02745978e59c3429642d536
https://doi.org/10.1021/acs.analchem.1c04101
https://doi.org/10.1021/acs.analchem.1c04101