Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Trisha A Rettig"'
Autor:
Trisha A Rettig, Bailey A Bye, Nina C Nishiyama, Savannah Hlavacek, Claire Ward, Michael J Pecaut, Stephen K Chapes
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210284 (2019)
Spaceflight affects the immune system, but the effects on the antibody repertoire, responsible for humoral immunity, has not been well explored. In particular, the complex gene assembly and expression process; including mutations, might make this pro
Externí odkaz:
https://doaj.org/article/29bb7291121a4eae9c89de2e8c698669
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190982 (2018)
Antibody specificity and diversity are generated through the enzymatic splicing of genomic gene segments within each B cell. Antibodies are heterodimers of heavy- and light-chains encoded on separate loci. We studied the antibody repertoire from pool
Externí odkaz:
https://doaj.org/article/b916f12c94c848c79999cecc802933c0
Publikováno v:
ImmunoHorizons. 5:675-686
Ab repertoire diversity plays a critical role in the host’s ability to fight pathogens. CDR3 is partially responsible for Ab–Ag binding and is a significant source of diversity in the repertoire. CDR3 diversity is generated during VDJ rearrangeme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e240c0d6c126c5a42867356006abc055
https://doi.org/10.4049/immunohorizons.2100056
https://doi.org/10.4049/immunohorizons.2100056
Publikováno v:
Gravitational and Space Research. 5:2-23
Spaceflight is known to affect immune cell populations. In particular, splenic B cell numbers decrease during spaceflight and in ground-based physiological models. Although antibody isotype changes have been assessed during and after space flight, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e2593c35c739cc6f3584ebc21917f32
https://doi.org/10.2478/gsr-2017-0001
https://doi.org/10.2478/gsr-2017-0001
Publikováno v:
Life Sci Space Res (Amst)
Spaceflight is known to impact the immune system in multiple ways. However, its effect on the antibody repertoire, especially in response to challenge, has not been well characterized. The development of the repertoire has multiple steps that could b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeba619912d6d88908708fd0570fc5f0
https://europepmc.org/articles/PMC6703179/
https://europepmc.org/articles/PMC6703179/
Publikováno v:
FASEB bioAdvances
Sequencing antibody repertoires has steadily become cheaper and easier. Sequencing methods usually rely on some form of amplification, often a massively multiplexed PCR prior to sequencing. To eliminate potential biases and create a data set that cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfab20a5c5207ba0d24d6828b8f3bb9
https://europepmc.org/articles/PMC6366624/
https://europepmc.org/articles/PMC6366624/
Publikováno v:
Gravitational and space research : publication of the American Society for Gravitational and Space Research. 5(1)
Spaceflight is known to affect immune cell populations. In particular, splenic B cell numbers decrease during spaceflight and in ground-based physiological models. Although antibody isotype changes have been assessed during and after space flight, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::35f92305fd07ac6fde944bc7bac1b66c
https://pubmed.ncbi.nlm.nih.gov/29270444
https://pubmed.ncbi.nlm.nih.gov/29270444
Autor:
Michael J. Pecaut, Savannah Hlavacek, Trisha A. Rettig, Bailey A. Bye, Stephen K. Chapes, Claire Ward
Spaceflight has been shown to suppress the adaptive immune response, altering the distribution and function of lymphocyte populations. B lymphocytes express highly specific and highly diversified receptors, known as immunoglobulins (Ig), that directl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16680337ea0fbbcc9a68a52ef0224143
https://europepmc.org/articles/PMC5826609/
https://europepmc.org/articles/PMC5826609/
Publikováno v:
The Journal of Immunology. 202:123.6-123.6
Each B cell produces an antibody composed of two heavy chains paired with two light chains. During development, B cells rearrange V-, D- (heavy chain only), and J-gene segments. These rearrangements along with the imprecisions in recombination and mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2485e511bfada63c7ea15a6e8c0efb2b
https://doi.org/10.4049/jimmunol.202.supp.123.6
https://doi.org/10.4049/jimmunol.202.supp.123.6
Publikováno v:
The Journal of Immunology. 196:64.7-64.7
While the process of antibody generation in response to pathogens and immunization is well understood, the normal antibody repertoire needs characterization to better understand the diversity of the antibody response. The antibody molecule is generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fc386a532fcd1e5977c7aaa0a43dd39
https://doi.org/10.4049/jimmunol.196.supp.64.7
https://doi.org/10.4049/jimmunol.196.supp.64.7