TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy

Autor: Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)

Background Adoptive cell therapy (ACT) has shown promising results for the treatment of cancer and viral infections. Successful ACT relies on ex vivo expansion of large numbers of desired T-cells with strong cytotoxic capacity and in vivo persistence

Externí odkaz: https://doaj.org/article/a25dad34aae2492e8875e883c1894921

Three doses of BNT162b2 COVID-19 mRNA vaccine establish long-lasting CD8+ T cell immunity in CLL and MDS patients

Autor: Susana Patricia Amaya Hernandez, Ditte Stampe Hersby, Kamilla Kjærgaard Munk, Tripti Tamhane, Darya Trubach, Maria Tagliamonte, Luigi Buonaguro, Anne Ortved Gang, Sine Reker Hadrup, Sunil Kumar Saini

Publikováno v: Frontiers in Immunology, Vol 13 (2023)

Patients with hematological malignancies are prioritized for COVID-19 vaccine due to their high risk for severe SARS-CoV-2 infection-related disease and mortality. To understand T cell immunity, its long-term persistence, and its correlation with ant

Externí odkaz: https://doaj.org/article/446f232763fe40f585f32949304fb662

CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

Autor: Natasja Wulff Pedersen, Anja Holm, Nikolaj Pagh Kristensen, Anne-Mette Bjerregaard, Amalie Kai Bentzen, Andrea Marion Marquard, Tripti Tamhane, Kristoffer Sølvsten Burgdorf, Henrik Ullum, Poul Jennum, Stine Knudsen, Sine Reker Hadrup, Birgitte Rahbek Kornum

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Autoreactive T cells are suspected to destroy hypocretin-producing neurons in narcolepsy. Here the authors detect CD8 T cells recognizing narcolepsy-related proteins in healthy individuals and in patients with narcolepsy, and show that the frequency

Externí odkaz: https://doaj.org/article/c43cf63b8c6f40c4b300f382f6e4affb

Construction of a plasmid coding for green fluorescent protein tagged cathepsin L and data on expression in colorectal carcinoma cells

Autor: Tripti Tamhane, Brit K. Wolters, Rukshala Illukkumbura, Gunhild M. Maelandsmo, Mads H. Haugen, Klaudia Brix

Publikováno v: Data in Brief, Vol 5, Iss C, Pp 468-475 (2015)

The endo-lysosomal cysteine cathepsin L has recently been shown to have moonlighting activities in that its unexpected nuclear localization in colorectal carcinoma cells is involved in cell cycle progression (Tamhane et al., 2015) [1]. Here, we show

Externí odkaz: https://doaj.org/article/0d409390a2544446a09bc55fc68454d1

Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma

Autor: Jeppe Sejerø Holm, Samuel A. Funt, Annie Borch, Kamilla Kjærgaard Munk, Anne-Mette Bjerregaard, James L. Reading, Colleen Maher, Ashley Regazzi, Phillip Wong, Hikmat Al-Ahmadie, Gopa Iyer, Tripti Tamhane, Amalie Kai Bentzen, Nana Overgaard Herschend, Susan De Wolf, Alexandra Snyder, Taha Merghoub, Jedd D. Wolchok, Morten Nielsen, Jonathan E. Rosenberg, Dean F. Bajorin, Sine Reker Hadrup

Publikováno v: Holm, J S, Funt, S A, Borch, A, Munk, K K, Bjerregaard, A-M, Reading, J L, Maher, C, Regazzi, A, Wong, P, Al-Ahmadie, H, Iyer, G, Tamhane, T, Bentzen, A K, Herschend, N O, De Wolf, S, Snyder, A, Merghoub, T, Wolchok, J D, Nielsen, M, Rosenberg, J E, Bajorin, D F & Hadrup, S R 2022, ' Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma ', Nature Communications, vol. 13, 1935 . https://doi.org/10.1038/s41467-022-29342-0

CD8+ T cell reactivity towards tumor mutation-derived neoantigens is widely believed to facilitate the antitumor immunity induced by immune checkpoint blockade (ICB). Here we show that broadening in the number of neoantigen-reactive CD8+ T cell (NART

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813ac1e222dad279434a7f8ea0fb16c3
https://pubmed.ncbi.nlm.nih.gov/35410325