Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer

Autor: Steven M. Hill, Shulin Xiang, David T. Pointer, David E. Blask, Tripp Frasch, Robert T. Dauchy, Aaron E. Hoffman

Publikováno v: J Pineal Res

Disruption of circadian time structure and suppression of circadian nocturnal melatonin (MLT) production by exposure to dim light at night (dLAN), as occurs with night shift work and/or disturbed sleep-wake cycles, is associated with a significantly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2300cf765a9e63ad0b81811f9c33c4
https://pubmed.ncbi.nlm.nih.gov/31077613

Doxorubicin resistance in breast cancer is driven by light at night-induced disruption of the circadian melatonin signal

Autor: Tripp Frasch, Lulu Mao, Adam Hauch, Victoria P. Belancio, Lin Yuan, Debasis Mondal, David E. Blask, Robert T. Dauchy, Shulin Xiang, Melissa A. Wren, Steven M. Hill

Publikováno v: Journal of Pineal Research. 59:60-69

Chemotherapeutic resistance, particularly to doxorubicin (Dox), represents a major impediment to successfully treating breast cancer and is linked to elevated tumor metabolism and tumor over-expression and/or activation of various families of recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9b5d71b8a8eeb50bdc7566cf749358
https://doi.org/10.1111/jpi.12239

Oscillation of Clock and Clock Controlled Genes Induced by Serum Shock in Human Breast Epithelial and Breast Cancer Cells: Regulation by Melatonin

Autor: Erin M. Dauchy, Tripp Frasch, Lin Yuan, Steven M. Hill, Tamika Duplessis, Lulu Mao, Shulin Xiang, Robert T. Dauchy, David E. Blask

Publikováno v: Breast Cancer: Basic and Clinical Research, Vol 2012, Iss 6, Pp 137-150 (2012)
Breast Cancer : Basic and Clinical Research
Breast Cancer: Basic and Clinical Research, Vol 6 (2012)

This study investigates differences in expression of clock and clock-controlled genes (CCGs) between human breast epithelial and breast cancer cells and breast tumor xenografts in circadian intact rats and examines if the pineal hormone melatonin inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2baa28bb1e562d2000dd2961082f801e
http://la-press.com/oscillation-of-clock-and-clock-controlled-genes-induced-by-serum-shock-a3334

Molecular Mechanisms of Melatonin Anticancer Effects

Autor: Tripp Frasch, Shulin Xiang, Lin Yuan, Tamika Duplessis, Steven M. Hill, Lulu Mao

Publikováno v: Integrative Cancer Therapies. 8:337-346

The authors have shown that, via activation of its MT1 receptor, melatonin modulates the transcriptional activity of various nuclear receptors and the proliferation of both ERα+ and ERα- human breast cancer cells. Employing dominant-negative (DN) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb4aee61b1afa493ea558962b35c261
https://doi.org/10.1177/1534735409353332

Melatonin suppression of aerobic glycolysis (Warburg effect), survival signalling and metastasis in human leiomyosarcoma

Autor: Lulu Mao, Kara Smith, Melissa A. Wren, Robert T. Dauchy, Lin Yuan, Samantha Brimer, Victoria P. Belancio, Lauren M. Slakey, Adam Hauch, Steven M. Hill, David E. Blask, Erin M. Dauchy, Tripp Frasch, Shulin Xiang

Publikováno v: Journal of pineal research. 60(2)

Leiomyosarcoma (LMS) represents a highly malignant, rare soft tissue sarcoma with high rates of morbidity and mortality. Previously, we demonstrated that tissue-isolated human LMS xenografts perfused in situ are highly sensitive to the direct antican

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbc547f7e5d7b46c6cb3d53a7b181d4
https://pubmed.ncbi.nlm.nih.gov/26607298