Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression

Autor: Dressman, Bruce A., Tromiczak, Eric G., Chappell, Mark D., Tripp, Allie E., Quimby, Steven J., Vetman, Tatiana, Fivush, Adam M., Matt, James, Jaramillo, Carlos, Li, Renhua, Khilevich, Albert, Blanco, Maria-Jesus, Smith, Stephon C., Carpintero, Mercedes, de Diego, José Eugenio, Barberis, Mario, García-Cerrada, Susana, Soriano, José F., Schkeryantz, Jeffrey M., Witkin, Jeffrey M., Wafford, Keith A., Seidel, Wesley, Britton, Thomas, Overshiner, Carl D., Li, Xia, Wang, Xu-Shan, Heinz, Beverly A., Catlow, John T., Swanson, Steven, Bedwell, David, Ornstein, Paul L., Mitch, Charles H.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 1 December 2016 26(23):5663-5668

Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like...

Autor: Chappell, Mark D., Renhua Li, Smith, Stephon C., Dressman, Bruce A., Tromiczak, Eric G., Tripp, Allie E., Blanco, Maria-Jesus, Vetman, Tatiana, Quimby, Steven J., Matt, James, Britton, Thomas C., Fivush, Adam M., Schkeryantz, Jeffrey M., Mayhugh, Daniel, Erickson, Jon A., Bures, Mark G., Jaramillo, Carlos, Carpintero, Mercedes, Diego, José Eugenio de, Barberis, Mario

Publikováno v: Journal of Medicinal Chemistry; Dec2016, Vol. 59 Issue 24, p10974-10993, 20p

Mutation of serine-39 to threonine in thermostable secondary alcohol dhydrogenase from...

Autor: Tripp, Allie E., Burdette, Douglas S., Zeikus, J. Gregory, Phillips, Robert S.

Publikováno v: Journal of the American Chemical Society. 06/03/98, Vol. 120 Issue 21, p5137. 5p. 1 Diagram, 4 Charts, 2 Graphs.

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Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.

Autor: Xu Y; Lilly Research Laboratories, A Division of Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA. xu_yanping@lilly.com, Rito CJ, Etgen GJ, Ardecky RJ, Bean JS, Bensch WR, Bosley JR, Broderick CL, Brooks DA, Dominianni SJ, Hahn PJ, Liu S, Mais DE, Montrose-Rafizadeh C, Ogilvie KM, Oldham BA, Peters M, Rungta DK, Shuker AJ, Stephenson GA, Tripp AE, Wilson SB, Winneroski LL, Zink R, Kauffman RF, McCarthy JR

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2004 May 06; Vol. 47 (10), pp. 2422-5.