Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Trinh T. Tran"'
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 3, Pp 756-763 (2010)
Although it is generally accepted that Aβ contributes to the pathogenesis of Alzheimer's disease (AD), other factors that impact the severity and time of onset of the disease are not well known. Aside from genetic factors, environmental factors such
Externí odkaz:
https://doaj.org/article/ae5e0b3222564292922dc83a30d4c1ed
Autor:
Michelle C.D. Bridi, Kaiwen He, Se-Young Choi, Trinh T. Tran, Yu Gu, Crystal L. Lantz, Andrew Dykman, Andrew Borrell, Alfredo Kirkwood, Elizabeth M. Quinlan, Roberto De Pasquale, Hey Kyoung Lee, Su Z. Hong
Publikováno v:
Nature Neuroscience. 21:843-850
Models of firing rate homeostasis such as synaptic scaling and the sliding synaptic plasticity modification threshold predict that decreasing neuronal activity (for example, by sensory deprivation) will enhance synaptic function. Manipulations of cor
Publikováno v:
Neurobiol Aging
Aging often impairs cognitive functions associated with the medial temporal lobe (MTL). Anatomical studies identified the layer II pyramidal cells of the lateral entorhinal cortex (LEC) as one of the most vulnerable elements within the MTL. These cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23fd4a2beee738fef146074e4692bc3
https://europepmc.org/articles/PMC9216165/
https://europepmc.org/articles/PMC9216165/
Autor:
Guanglin Wang, Jiaqian Qiu, Kaiwen He, Nancy Luo, Daniel Severin, Xia Min, Zheng-Jiang Zhu, Michelle C.D. Bridi, Trinh T. Tran, Fang Jiao Zong, Alfredo Kirkwood, Xue Ting Zhang
Publikováno v:
Neuron
A dynamic balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing. In line with this idea, measures of the E/I balance are reportedly comparable acros
Autor:
Horacio G. Rotstein, Daniel Severin, Trinh T. Tran, Cagri T. Unal, Alfredo Kirkwood, Laszlo Zaborszky, Jorge Golowasch
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Ionic currents, whether measured as conductance amplitude or as ion channel transcript numbers, can vary many-fold within a population of identified neurons. In invertebrate neuronal types multiple currents can be seen to vary while at the same time
Publikováno v:
The Journal of Neuroscience. 36:10285-10295
Maturation of excitatory drive onto fast-spiking interneurons (FS INs) in the visual cortex has been implicated in the control of the timing of the critical period for ocular dominance plasticity. However, the mechanisms that regulate the strength of
Autor:
Michela Gallagher, Alvaro O. Ardiles, Paul F. Worley, Gonzalo Valdivia, Adrian G. Palacios, Alfredo Kirkwood, Sunggu Yang, Rafael Posada-Duque, Yang An Chuang, Trinh T. Tran, Min Baek, Hui Wang
Publikováno v:
The Journal of Neuroscience. 36:1723-1729
Activity-dependent bidirectional modifications of excitatory synaptic strength are essential for learning and storage on new memories. Research on bidirectional synaptic plasticity has largely focused on long-term potentiation (LTP) and long-term dep
Publikováno v:
Neurobiology of aging. 70
Hyperactivity within the hippocampal formation, frequently observed in aged individuals, is thought to be a potential contributing mechanism to the memory decline often associated with aging. Consequently, we evaluated the postsynaptic strength of ex
Autor:
Trinh T. Tran, Kiara C. Eldred, Hey Kyoung Lee, Alfredo Kirkwood, Hyang Sook Hoe, Andrea Megill, Nathanael J. Lee, Philip C. Wong
Publikováno v:
Journal of Neuroscience. 35:11346-11357
Much of the molecular understanding of synaptic pathology in Alzheimer9s disease (AD) comes from studies of various mouse models that express familial AD (FAD)-linked mutations, often in combinations. Most studies compare the absolute magnitudes of l
Autor:
Trinh T. Tran, Karim A. Alkadhi
Publikováno v:
Brain Research. 1588:150-158
The CA1 and dentate gyrus regions of the hippocampus are physically and functionally closely related but they react differently to insults. This study examined the effect of chronic psychosocial stress on the dentate gyrus of an at-risk (preclinical)