Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Trine V. Axelsen"'
Autor:
Soojung Lee, Nicolai J. Toft, Trine V. Axelsen, Maria Sofia Espejo, Tina M. Pedersen, Marco Mele, Helene L. Pedersen, Eva Balling, Tonje Johansen, Mark Burton, Mads Thomassen, Pernille Vahl, Peer Christiansen, Ebbe Boedtkjer
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-27 (2023)
Abstract Background Carbonic anhydrases catalyze CO2/HCO3 – buffer reactions with implications for effective H+ mobility, pH dynamics, and cellular acid–base sensing. Yet, the integrated consequences of carbonic anhydrases for cancer and stromal
Externí odkaz:
https://doaj.org/article/43eb9c61abb047289a64eb505c8ecf73
Autor:
Nicolai J Toft, Trine V Axelsen, Helene L Pedersen, Marco Mele, Mark Burton, Eva Balling, Tonje Johansen, Mads Thomassen, Peer M Christiansen, Ebbe Boedtkjer
Publikováno v:
eLife, Vol 10 (2021)
Breast cancer heterogeneity in histology and molecular subtype influences metabolic and proliferative activity and hence the acid load on cancer cells. We hypothesized that acid-base transporters and intracellular pH (pHi) dynamics contribute inter-i
Externí odkaz:
https://doaj.org/article/d654619d0e9a42edb5ad6ac158c69716
Autor:
Rasmus A. Sloth, Trine V. Axelsen, Maria Sofia Espejo, Nicolai J. Toft, Ninna C. S. Voss, Mark Burton, Mads Thomassen, Pernille Vahl, Ebbe Boedtkjer
Publikováno v:
Sloth, R A, Axelsen, T V, Espejo, M S, Toft, N J, Voss, N C S, Burton, M, Thomassen, M, Vahl, P & Boedtkjer, E 2022, ' Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival ', British Journal of Cancer, vol. 127, no. 7, pp. 1226-1238 . https://doi.org/10.1038/s41416-022-01911-6
Background: While cellular metabolism and acidic waste handling accelerate during breast carcinogenesis, temporal patterns of acid–base regulation and underlying molecular mechanisms responding to the tumour microenvironment remain unclear. Methods
Autor:
Mads Thomassen, Peer Christiansen, Trine V Axelsen, Ebbe Boedtkjer, Marco Mele, Helene L Pedersen, Tonje Johansen, Mark Burton, Eva Balling, Nicolai J Toft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbe84be00a67f928d3ce2c04baa5fba9
https://doi.org/10.7554/elife.68447.sa2
https://doi.org/10.7554/elife.68447.sa2
Autor:
Nicolai Jessen, Ebbe Boedtkjer, Stine F. Pedersen, Trine V Axelsen, Soojung Lee, Pernille Vahl
Publikováno v:
Lee, S, Axelsen, T V, Jessen, N, Pedersen, S F, Vahl, P & Boedtkjer, E 2018, ' Na +,HCO 3 –-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice ', Oncogene, vol. 37, no. 41, pp. 5569-5584 . https://doi.org/10.1038/s41388-018-0353-6
Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7654b11d4dea51650c8a3abd257d60ad
https://pure.au.dk/portal/da/publications/na-hco3cotransporter-nbcn1-slc4a7-accelerates-erbb2induced-breast-cancer-development-and-tumor-growth-in-mice(b1077be5-30cd-4d20-acfa-cbf2016586c9).html
https://pure.au.dk/portal/da/publications/na-hco3cotransporter-nbcn1-slc4a7-accelerates-erbb2induced-breast-cancer-development-and-tumor-growth-in-mice(b1077be5-30cd-4d20-acfa-cbf2016586c9).html
Autor:
Soojung, Lee, Trine V, Axelsen, Nicolai, Jessen, Stine F, Pedersen, Pernille, Vahl, Ebbe, Boedtkjer
Publikováno v:
Oncogene. 37(41)
Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribu
Publikováno v:
Vaccine. 29:3260-3269
Alzheimer's disease (AD) is characterized by neurofibrillary tangles, consisting of hyperphosphorylated tau protein and senile plaques, which are consisting mainly of amyloid-β (Aβ). Attempts to generate a safe vaccine against Aβ rely on both B- a
Autor:
Trine V Axelsen
Publikováno v:
Alzheimer's & Dementia. 6
Autor:
Svend Birkelund, Gunna Christiansen, Michael Ploug, Trine V Axelsen, Arne Holm, Ida Elisabeth Holm
Publikováno v:
Axelsen, T V, Holm, A, Birkelund, S, Christiansen, G, Ploug, M & Holm, I E 2009, ' Specific recognition of the C-terminal end of A beta 42 by a high affinity monoclonal antibody ', Molecular Immunology, vol. 46, no. 11-12, pp. 2267-73 . https://doi.org/10.1016/j.molimm.2009.04.007
Udgivelsesdato: 2009-Jul The neurotoxic peptide A beta(42) is derived from the amyloid precursor protein by proteolytic cleavage and is deposited in the brain of patients suffering from Alzheimer's disease (AD). In this study we generate a high affin