Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Trine S. Nicolaisen"'
Autor:
Anders B. Klein, Trine S. Nicolaisen, Niels Ørtenblad, Kasper D. Gejl, Rasmus Jensen, Andreas M. Fritzen, Emil L. Larsen, Kristian Karstoft, Henrik E. Poulsen, Thomas Morville, Ronni E. Sahl, Jørn W. Helge, Jens Lund, Sarah Falk, Mark Lyngbæk, Helga Ellingsgaard, Bente K. Pedersen, Wei Lu, Brian Finan, Sebastian B. Jørgensen, Randy J. Seeley, Maximilian Kleinert, Bente Kiens, Erik A. Richter, Christoffer Clemmensen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The physiological role of GDF15 remains poorly defined. Here, the authors show that circulating GDF15 increases in response to prolonged exercise, but that this exercise-induced GDF15, unlike pharmacological GDF15, does not affect post-exercise food
Externí odkaz:
https://doaj.org/article/8f1d9eea4091471ca84ea46086fb7636
Autor:
Anne-Marie Lundsgaard, Andreas M. Fritzen, Trine S. Nicolaisen, Christian S. Carl, Kim A. Sjøberg, Steffen H. Raun, Anders B. Klein, Eva Sanchez-Quant, Jakob Langer, Cathrine Ørskov, Christoffer Clemmensen, Matthias H. Tschöp, Erik A. Richter, Bente Kiens, Maximilian Kleinert
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 1, Pp 10-19 (2020)
Excessive circulating FAs have been proposed to promote insulin resistance (IR) of glucose metabolism by increasing the oxidation of FAs over glucose. Therefore, inhibition of FA oxidation (FAOX) has been suggested to ameliorate IR. However, prolonge
Externí odkaz:
https://doaj.org/article/d93f2afb21af4c3f990999f0bf005ed4
Autor:
Andreas Mæchel Fritzen, Joan Domingo-Espín, Anne-Marie Lundsgaard, Maximilian Kleinert, Ida Israelsen, Christian S. Carl, Trine S. Nicolaisen, Rasmus Kjøbsted, Jacob F. Jeppesen, Jørgen F.P. Wojtaszewski, Jens O. Lagerstedt, Bente Kiens
Publikováno v:
Molecular Metabolism, Vol 35, Iss , Pp - (2020)
Objective: Acute administration of the main protein component of high-density lipoprotein, apolipoprotein A-I (ApoA-1), improves glucose uptake in skeletal muscle. The molecular mechanisms mediating this are not known, but in muscle cell cultures, Ap
Externí odkaz:
https://doaj.org/article/e7375ff2f5d843a68500a32a5a557945
Autor:
Mark Lyngbæk, Rasmus Jensen, Andreas M. Fritzen, Anders B. Klein, Sarah Falk, Niels Ørtenblad, Christoffer Clemmensen, Henrik E. Poulsen, Ronni E. Sahl, Maximilian Kleinert, Jens Lund, Randy J. Seeley, Emil List Larsen, Kasper Degn Gejl, Brian Finan, Bente Klarlund Pedersen, Jørn Wulff Helge, Helga Ellingsgaard, Erik A. Richter, Bente Kiens, Trine S. Nicolaisen, Kristian Karstoft, Sebastian Beck Jørgensen, Wei Lu, Thomas Morville
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Klein, A B, Nicolaisen, T S, Ørtenblad, N, Gejl, K D, Jensen, R, Fritzen, A M, Larsen, E L, Karstoft, K, Poulsen, H E, Morville, T, Sahl, R E, Helge, J W, Lund, J, Falk, S, Lyngbæk, M, Ellingsgaard, H, Pedersen, B K, Lu, W, Finan, B, Jørgensen, S B, Seeley, R J, Kleinert, M, Kiens, B, Richter, E A & Clemmensen, C 2021, ' Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise ', Nature Communications, vol. 12, 1041 . https://doi.org/10.1038/s41467-021-21309-x
Nat. Commun. 12:1041 (2021)
Nature Communications
Klein, A B, Nicolaisen, T S, Ørtenblad, N, Gejl, K D, Jensen, R, Fritzen, A M, Larsen, E L, Karstoft, K, Poulsen, H E, Morville, T, Sahl, R E, Helge, J W, Lund, J, Falk, S, Lyngbæk, M, Ellingsgaard, H, Pedersen, B K, Lu, W, Finan, B, Jørgensen, S B, Seeley, R J, Kleinert, M, Kiens, B, Richter, E A & Clemmensen, C 2021, ' Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise ', Nature Communications, vol. 12, 1041 . https://doi.org/10.1038/s41467-021-21309-x
Nat. Commun. 12:1041 (2021)
Growing evidence supports that pharmacological application of growth differentiation factor 15 (GDF15) suppresses appetite but also promotes sickness-like behaviors in rodents via GDNF family receptor α-like (GFRAL)-dependent mechanisms. Conversely,
Autor:
Anders B. Klein, Trine S. Nicolaisen, Kornelia Johann, Andreas M. Fritzen, Cecilie V. Mathiesen, Cláudia Gil, Nanna S. Pilmark, Kristian Karstoft, Martin B. Blond, Jonas S. Quist, Randy J. Seeley, Kristine Færch, Jens Lund, Maximilian Kleinert, Christoffer Clemmensen
Publikováno v:
Klein, A B, Nicolaisen, T S, Johann, K, Fritzen, A M, Mathiesen, C V, Gil, C, Pilmark, N S, Karstoft, K, Blond, M B, Quist, J S, Seeley, R J, Færch, K, Lund, J, Kleinert, M & Clemmensen, C 2022, ' The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance ', Cell Reports, vol. 40, no. 8, 111258 . https://doi.org/10.1016/j.celrep.2022.111258
SUMMARYMetformin is a blood glucose lowering medication with physiological effects that extend beyond its anti-diabetic indication. Recently, it was reported that metformin lowers body weight via induction of growth differentiation factor 15 (GDF15),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d41a96f373a7ef9316cebc74a70de3
https://doi.org/10.1101/2022.02.16.480373
https://doi.org/10.1101/2022.02.16.480373
Autor:
Zachary Gerhart-Hines, Anders B. Klein, Andreas M. Fritzen, Christoffer Clemmensen, Anne-Marie Lundsgaard, Steen Larsen, Oksana Dmytriyeva, Lars R. Ingerslev, Frédéric Flamant, Tao Ma, Karine Gauthier, Mikkel Frost, Christian S. Carl, Peter Schjerling, Erik A. Richter, Bente Kiens, Trine S. Nicolaisen, Jens Lund
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (11), pp.15480-15491. ⟨10.1096/fj.202001258RR⟩
Nicolaisen, T S, Klein, A B, Dmytriyeva, O, Lund, J, Ingerslev, L R, Fritzen, A M, Carl, C S, Lundsgaard, A, Frost, M, Ma, T, Schjerling, P, Gerhart-Hines, Z, Flamant, F, Gauthier, K, Larsen, S, Richter, E A, Kiens, B & Clemmensen, C 2020, ' Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure ', F A S E B Journal, vol. 34, no. 11, pp. 15480-15491 . https://doi.org/10.1096/fj.202001258RR
The FASEB Journal
FASEB Journal, 2020, 34 (11), pp.15480-15491. ⟨10.1096/fj.202001258RR⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (11), pp.15480-15491. ⟨10.1096/fj.202001258RR⟩
Nicolaisen, T S, Klein, A B, Dmytriyeva, O, Lund, J, Ingerslev, L R, Fritzen, A M, Carl, C S, Lundsgaard, A, Frost, M, Ma, T, Schjerling, P, Gerhart-Hines, Z, Flamant, F, Gauthier, K, Larsen, S, Richter, E A, Kiens, B & Clemmensen, C 2020, ' Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure ', F A S E B Journal, vol. 34, no. 11, pp. 15480-15491 . https://doi.org/10.1096/fj.202001258RR
The FASEB Journal
FASEB Journal, 2020, 34 (11), pp.15480-15491. ⟨10.1096/fj.202001258RR⟩
Thyroid hormones are important for homeostatic control of energy metabolism and body temperature. Although skeletal muscle is considered a key site for thyroid action, the contribution of thyroid hormone receptor signaling in muscle to whole-body ene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcec524bdc6d1aa720ed5d6c3c03461
https://hal.archives-ouvertes.fr/hal-02996920
https://hal.archives-ouvertes.fr/hal-02996920
Autor:
Ida Marchen Egerod Israelsen, Anne-Marie Lundsgaard, Jacob Jeppesen, Andreas M. Fritzen, Maximilian Kleinert, Bente Kiens, Trine S. Nicolaisen, Joan Domingo-Espín, Christian S. Carl, Rasmus Kjøbsted, Jørgen F. P. Wojtaszewski, Jens O. Lagerstedt
Publikováno v:
Molecular Metabolism
Mol. Metab. 35:100949 (2020)
Molecular Metabolism, Vol 35, Iss, Pp-(2020)
Fritzen, A M, Domingo-Espín, J, Lundsgaard, A, Kleinert, M, Israelsen, I, Carl, C S, Nicolaisen, T S, Kjøbsted, R, Jeppesen, J F, Wojtaszewski, J, Lagerstedt, J O & Kiens, B 2020, ' ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα 2 ', Molecular Metabolism, vol. 35, 100949 . https://doi.org/10.1016/j.molmet.2020.01.013
Mol. Metab. 35:100949 (2020)
Molecular Metabolism, Vol 35, Iss, Pp-(2020)
Fritzen, A M, Domingo-Espín, J, Lundsgaard, A, Kleinert, M, Israelsen, I, Carl, C S, Nicolaisen, T S, Kjøbsted, R, Jeppesen, J F, Wojtaszewski, J, Lagerstedt, J O & Kiens, B 2020, ' ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα 2 ', Molecular Metabolism, vol. 35, 100949 . https://doi.org/10.1016/j.molmet.2020.01.013
Objective Acute administration of the main protein component of high-density lipoprotein, apolipoprotein A-I (ApoA-1), improves glucose uptake in skeletal muscle. The molecular mechanisms mediating this are not known, but in muscle cell cultures, Apo
Autor:
Erik A. Richter, Bente Kiens, Trine S. Nicolaisen, Kerstin Stemmer, Christoffer Clemmensen, Stephan Sachs, Anne-Marie Lundsgaard, Timo D. Müller, Karl-Werner Schramm, Andreas M. Fritzen, Sigrid Jall, Anders B. Klein, Matthias H. Tschöp, Maximilian Kleinert, Meri De Angelis, Aaron Novikoff
Publikováno v:
Diabetologia
Jall, S, De Angelis, M, Lundsgaard, A, Fritzen, A M, Nicolaisen, T S, Klein, A B, Novikoff, A, Sachs, S, Richter, E A, Kiens, B, Schramm, K-W, Tschöp, M H, Stemmer, K, Clemmensen, C, Müller, T D & Kleinert, M 2020, ' Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity ', Diabetologia, vol. 63, no. 6, pp. 1236-1247 . https://doi.org/10.1007/s00125-020-05117-4
Jall, S, De Angelis, M, Lundsgaard, A, Fritzen, A M, Nicolaisen, T S, Klein, A B, Novikoff, A, Sachs, S, Richter, E A, Kiens, B, Schramm, K-W, Tschöp, M H, Stemmer, K, Clemmensen, C, Müller, T D & Kleinert, M 2020, ' Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity ', Diabetologia, vol. 63, no. 6, pp. 1236-1247 . https://doi.org/10.1007/s00125-020-05117-4
Aims/hypothesis Treatment with the α3β4 nicotinic acetylcholine receptor (nAChR) agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), improves glucose tolerance in diet-induced obese (DIO) mice, but the physiological and molecular mechanisms a
Autor:
Erik A. Richter, Bente Kiens, Eva Sanchez-Quant, Steffen H. Raun, Anne-Marie Lundsgaard, Trine S. Nicolaisen, Jakob Langer, Anders B. Klein, Christoffer Clemmensen, Matthias H. Tschöp, Kim A. Sjøberg, Christian S. Carl, Cathrine Ørskov, Maximilian Kleinert, Andreas M. Fritzen
Publikováno v:
J Lipid Res
Lundsgaard, A, Fritzen, A M, Nicolaisen, T S, Carl, C S, Sjøberg, K A, Raun, S H, Klein, A B, Sanchez-Quant, E, Langer, J, Ørskov, C, Clemmensen, C, Tschöp, M H, Richter, E A, Kiens, B & Kleinert, M 2020, ' Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation ', Journal of Lipid Research, vol. 61, no. 1, pp. 10-19 . https://doi.org/10.1194/jlr.RA119000177
J. Lipid Res. 61, 10-19 (2020)
Journal of Lipid Research, Vol 61, Iss 1, Pp 10-19 (2020)
Lundsgaard, A, Fritzen, A M, Nicolaisen, T S, Carl, C S, Sjøberg, K A, Raun, S H, Klein, A B, Sanchez-Quant, E, Langer, J, Ørskov, C, Clemmensen, C, Tschöp, M H, Richter, E A, Kiens, B & Kleinert, M 2020, ' Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation ', Journal of Lipid Research, vol. 61, no. 1, pp. 10-19 . https://doi.org/10.1194/jlr.RA119000177
J. Lipid Res. 61, 10-19 (2020)
Journal of Lipid Research, Vol 61, Iss 1, Pp 10-19 (2020)
Excessive circulating fatty acids (FAs) have been proposed to promote insulin resistance of glucose metabolism by increasing the oxidation of FAs over glucose. Therefore, inhibition of FA oxidation (FAOX) has been suggested to ameliorate insulin resi
Autor:
Sophia Doll, Atul S. Deshmukh, Even Fjære, Lene Secher Myrmel, Jørgen F. P. Wojtaszewski, Erik A. Richter, Bente Kiens, Benjamin A. H. Jensen, Anne-Marie Lundsgaard, Trine S. Nicolaisen, Kirstine N. Bojsen-Møller, Jens J. Holst, Karsten Kristiansen, Kim A. Sjøberg, Philipp E. Geyer, Janne R. Hingst, Sine L. Hansen, Jacob Bak Holm, Lise Madsen
Publikováno v:
Cell metabolism. 29(1)
Summary Prolonged intervention studies investigating molecular metabolism are necessary for a deeper understanding of dietary effects on health. Here we provide mechanistic information about metabolic adaptation to fat-rich diets. Healthy, slightly o