Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Trine Porsgaard"'
Autor:
Frantisek Hubálek, Hanne H. F. Refsgaard, Sanne Gram-Nielsen, Peter Madsen, Erica Nishimura, Martin Münzel, Christian Lehn Brand, Carsten Enggaard Stidsen, Christian Hove Claussen, Erik Max Wulff, Lone Pridal, Ulla Ribel, Jonas Kildegaard, Trine Porsgaard, Eva Johansson, Dorte Bjerre Steensgaard, Lars Hovgaard, Tine Glendorf, Bo Falck Hansen, Maja Kirkegaard Jensen, Peter Kresten Nielsen, Svend Ludvigsen, Susanne Rugh, Patrick W. Garibay, Mary Courtney Moore, Alan D. Cherrington, Thomas Kjeldsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues.
Externí odkaz:
https://doaj.org/article/b3637544155945e480839f9c67516402
Autor:
Frantisek Hubálek, Hanne H. F. Refsgaard, Sanne Gram-Nielsen, Peter Madsen, Erica Nishimura, Martin Münzel, Christian Lehn Brand, Carsten Enggaard Stidsen, Christian Hove Claussen, Erik Max Wulff, Lone Pridal, Ulla Ribel, Jonas Kildegaard, Trine Porsgaard, Eva Johansson, Dorte Bjerre Steensgaard, Lars Hovgaard, Tine Glendorf, Bo Falck Hansen, Maja Kirkegaard Jensen, Peter Kresten Nielsen, Svend Ludvigsen, Susanne Rugh, Patrick W. Garibay, Mary Courtney Moore, Alan D. Cherrington, Thomas Kjeldsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/f3cf07c418ea4af69c46d62c9eb076b7
Autor:
Christina Pedersen, Trine Porsgaard, Maria Thomsen, Mette Marie Rosenkilde, Nikolaj Kulahin Roed
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194468 (2018)
Insulin is a vital part of diabetes treatment, whereas glucagon is primarily used to treat insulin-induced hypoglycemia. However, glucagon is suggested to have a central role in the regulation of body weight, which would be beneficial for diabetic pa
Externí odkaz:
https://doaj.org/article/40a5ce0aefe944508eeea8fafa7e9ca3
Autor:
Anna Katrina Jógvansdóttir Gradel, Jens Lykkesfeldt, Hanne H. F. Refsgaard, Jonas Kildegaard, Trine Porsgaard
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 128:783-794
In humans, food intake and glucose infusion have been reported to increase subcutaneous blood flow. Since local blood flow influences the rate of insulin absorption from the subcutaneous tissue, we hypothesised that an increase in blood glucose level
Autor:
Erik M. Wulff, Patrick William Garibay, Eva Johansson, Martin Münzel, Tine Glendorf, Erica Nishimura, Bo Falck Hansen, Thomas Kjeldsen, Peter Madsen, Christian L. Brand, Sanne Gram-Nielsen, Trine Porsgaard, Hanne H. F. Refsgaard, Frantisek Hubalek, Svend Ludvigsen, Dorte Bjerre Steensgaard, Lars Hovgaard, Carsten Enggaard Stidsen, Susanne Rugh, Jonas Kildegaard, Lone Pridal, Maja Jensen, Christian Hove Claussen, Ulla Ribel, Alan D. Cherrington, Mary Courtney Moore, Peter Kresten Nielsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Recently, the clinical proof of concept for the first ultra-long oral insulin was reported, showing efficacy and safety similar to subcutaneously administered insulin glargine. Here, we report the molecular engineering as well as biological and pharm
Autor:
Johannes Josef Fels, Anne Marie V. Schou-Pedersen, Jonas Kildegaard, Jens Lykkesfeldt, Trine Pagh Ludvigsen, Hanne H. F. Refsgaard, Anna Katrina Jógvansdóttir Gradel, Trine Porsgaard
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 127:278-286
The domestic pig is commonly used as animal model in the pharmaceutical development of new therapeutics for treatment of diabetes. Since a formal definition of hypoglycaemia only exists in humans, the purpose of this study was to assess the counterre
Autor:
Peter Madsen, Thomas Kjeldsen, Claus Bekker Jeppesen, Hanne H. F. Refsgaard, Trine Porsgaard, Helle Naver, Sanne Gram-Nielsen, Frantisek Hubalek, Lone Pridal, Tina Møller Tagmose, Erica Nishimura, Inger Lautrup-Larsen, Carsten Enggaard Stidsen, Valentina Manfè, Thomas Hoeg-Jensen, Claudia Ulrich Hjørringgaard, Svend Ludvigsen, Christian Fledelius
Publikováno v:
Journal of medicinal chemistry. 64(13)
Here, we describe the molecular engineering of insulin icodec to achieve a plasma half-life of 196 h in humans, suitable for once-weekly subcutaneously administration. Insulin icodec is based on re-engineering of the ultra-long oral basal insulin OI3
Autor:
Ulla Ribel, Erik M. Wulff, Alan D. Cherrington, Peter Kresten Nielsen, Martin Münzel, Thomas Kjeldsen, Svend Ludvigsen, Frantisek Hubalek, Lars Hovgaard, Christian Hove Claussen, Jonas Kildegaard, Maja Jensen, Lone Pridal, Hanne H. F. Refsgaard, Patrick William Garibay, Mary Courtney Moore, Sanne Gram-Nielsen, Erica Nishimura, Dorte Bjerre Steensgaard, Carsten Enggaard Stidsen, Tine Glendorf, Peter Madsen, Susanne Rugh, Bo Falck Hansen, Eva Johansson, Christian L. Brand, Trine Porsgaard
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Autor:
Hanne Hoffmann Frølund Refsgaard, Jens Lykkesfeldt, Per B. Brockhoff, Torben Seested, Anna Katrina Jógvansdóttir Gradel, Trine Porsgaard
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 128:332-338
Background In humans, subcutaneous administration of insulin in the abdominal region or arm is associated with a faster absorption compared to the thigh or buttocks. We hypothesised that this is partly caused by differences in injection depot structu
Autor:
Jonas Ahnfelt-Rønne, Henning Hvid, Borja Ballarín-González, Trine Porsgaard, Erica Nishimura, Mikkel S Jørgensen, Kim Kristensen, Jonas Kildegaard, Bo Falck Hansen
Publikováno v:
J Diabetes Sci Technol
Background: Oral delivery of insulin was recently demonstrated to have therapeutic relevance in patients with diabetes. Insulin receptors are expressed in the gastrointestinal tract and can be activated by insulin in the bloodstream, but it is not kn