Can Animal Models of Copy Number Variants That Predispose to Schizophrenia Elucidate Underlying Biology?

Autor: Trine Nygaard Jørgensen, Michael Didriksen, Line Olsen, Annika Forsingdal, Jacob Nielsen, Thomas Werge

Publikováno v: Biological Psychiatry

Background Elevated striatal dopamine synthesis capacity has been implicated in the etiology and antipsychotic response in psychotic illness. The effects of antipsychotic medication on dopamine synthesis capacity are poorly understood, and no prospec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967a563bda0bb5f8bb6247c920e808a4
https://doi.org/10.1016/j.biopsych.2018.07.004

Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

Autor: Matthew D. Lycas, Trine Nygaard Jørgensen, Simon Erlendsson, Freja Herborg Hansen, Troels Rahbek-Clemmensen, Mia Apuschkin, Frederik Vilhardt, Ulrik Gether, Jacob Eriksen

Publikováno v: Rahbek-Clemmensen, T, Lycas, M D, Erlendsson, S, Eriksen, J, Apuschkin, M, Vilhardt, F, Jorgensen, T N, Hansen, F H & Gether, U 2017, ' Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains ', Nature Communications, vol. 8, 740 . https://doi.org/10.1038/s41467-017-00790-3
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications

Dopamine regulates reward, cognition, and locomotor functions. By mediating rapid reuptake of extracellular dopamine, the dopamine transporter is critical for spatiotemporal control of dopaminergic neurotransmission. Here, we use super-resolution ima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128959611d1b7be377ecc4ad18f184ba
https://curis.ku.dk/portal/da/publications/superresolution-microscopy-reveals-functional-organization-of-dopamine-transporters-into-cholesterol-and-neuronal-activitydependent-nanodomains(68253fcf-2687-4ce3-9ab1-2d8db472152c).html

Novel and High Affinity Fluorescent Ligands for the Serotonin Transporter Based on (S)-Citalopram

Autor: Christian B. Billesbølle, Amy Hauck Newman, Trine Nygaard Jørgensen, Vivek Kumar, Ulrik Gether, Troels Rahbek-Clemmensen

Publikováno v: ACS Medicinal Chemistry Letters. 5:696-699

Novel rhodamine-labeled ligands, based on (S)-citalopram, were synthesized and evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine transporters (hSERT, hDAT, and hNET, respectively) and for binding at SERT, in transie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9006b266040d7feda8508d505047bb
https://doi.org/10.1021/ml5000806

A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function

Autor: Ulrik Gether, Anne Vuorenpää, Trine Nygaard Jørgensen, Ina Ammendrup-Johnsen

Publikováno v: Neurochemistry international. 98

The high affinity transporters for the monoamine neurotransmitters, dopamine, norepinephrine, and serotonin, play a key role in controlling monoaminergic neurotransmission. It is believed that the transporters (DAT, NET and SERT, respectively) are su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af0fce0e3294cadbd5ddc0aba6b9a12
https://pubmed.ncbi.nlm.nih.gov/27020406

Postendocytic Sorting of Constitutively Internalized Dopamine Transporter in Cell Lines and Dopaminergic Neurons

Autor: Walden E. Bjørn-Yoshimoto, Ulrik Gether, Trine Nygaard Jørgensen, Jacob Eriksen, Amy Hauck Newman

Publikováno v: Journal of Biological Chemistry. 285:27289-27301

The dopamine transporter (DAT) mediates reuptake of released dopamine and is the target for psychostimulants, such as cocaine and amphetamine. DAT undergoes marked constitutive endocytosis, but little is known about the fate and sorting of the endocy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be07e62d3b1c627080dfb5293656b00f
https://doi.org/10.1074/jbc.m110.131003