Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Trine Lisberg Toft-Bertelsen"'
Autor:
Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B. Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Toft-Bertelsen et al. describe repurposing of anti-influenza drug amantadine and its derivatives for the treatment of SARS-CoV-2. They show that Amantadine, Emodin and Xanthene show significant blockage of ionchannels formed by SARS-CoV-2 which are c
Externí odkaz:
https://doaj.org/article/f7013bc495364bc4bcb0878e0dba41ad
Autor:
Trine Lisberg Toft-Bertelsen, Mads Gravers Jeppesen, Eva Tzortzini, Kai Xue, Karin Giller, Stefan Becker, Amer Mujezinovic, Bo Hjorth Bentzen, Loren B. Andreas, Antonios Kolocouris, Thomas Nitschke Kledal, Mette Marie Rosenkilde
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/8086986427c346fda2f41caae9811ec2
Autor:
David Križaj, Nanna MacAulay, Tam T. T. Phuong, Trine Lisberg Toft-Bertelsen, Oleg Yarishkin, Sarah Redmon
Publikováno v:
J Biol Chem
Toft-Bertelsen, T L, Yarishkin, O, Redmon, S, Phuong, T T T, Krizaj, D & MacAulay, N 2019, ' Volume sensing in the transient receptor potential vanilloid 4 ion channel is cell type-specific and mediated by an N-terminal volume-sensing domain ', Journal of Biological Chemistry, vol. 294, no. 48, pp. 18421-18434 . https://doi.org/10.1074/jbc.RA119.011187
Toft-Bertelsen, T L, Yarishkin, O, Redmon, S, Phuong, T T T, Krizaj, D & MacAulay, N 2019, ' Volume sensing in the transient receptor potential vanilloid 4 ion channel is cell type-specific and mediated by an N-terminal volume-sensing domain ', Journal of Biological Chemistry, vol. 294, no. 48, pp. 18421-18434 . https://doi.org/10.1074/jbc.RA119.011187
Many retinal diseases are associated with pathological cell swelling, but the underlying etiology remains to be established. A key component of the volume-sensitive machinery, the transient receptor potential vanilloid 4 (TRPV4) ion channel, may repr
Autor:
Loren B. Andreas, Amer Mujezinovic, Kai Xue, Antonios Kolocouris, Bo Hjorth Bentzen, Trine Lisberg Toft-Bertelsen, Mette M. Rosenkilde, Thomas N. Kledal, Karin Giller, Eva Tzortzini, Stefan Becker, Mads G. Jeppesen
Publikováno v:
Communications Biology
Toft-Bertelsen, T L, Jeppesen, M G, Tzortzini, E, Xue, K, Giller, K, Becker, S, Mujezinovic, A, Bentzen, B H, Andreas, L B, Kolocouris, A, Kledal, T N & Rosenkilde, M M 2021, ' Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro ', Communications Biology, vol. 4, 1347 . https://doi.org/10.1038/s42003-021-02866-9
Toft-Bertelsen, T L, Jeppesen, M G, Tzortzini, E, Xue, K, Giller, K, Becker, S, Mujezinovic, A, Bentzen, B H, Andreas, L B, Kolocouris, A, Kledal, T N & Rosenkilde, M M 2021, ' Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitro ', Communications Biology, vol. 4, 1347 . https://doi.org/10.1038/s42003-021-02866-9
The dire need for COVID-19 treatments has inspired strategies of repurposing approved drugs. Amantadine has been suggested as a candidate, and cellular as well as clinical studies have indicated beneficial effects of this drug. We demonstrate that am
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Toft-Bertelsen, T L & MacAulay, N 2021, ' TRPing on Cell Swelling-TRPV4 Senses It ', Frontiers in Immunology, vol. 12, 730982 . https://doi.org/10.3389/fimmu.2021.730982
Frontiers in Immunology
Toft-Bertelsen, T L & MacAulay, N 2021, ' TRPing on Cell Swelling-TRPV4 Senses It ', Frontiers in Immunology, vol. 12, 730982 . https://doi.org/10.3389/fimmu.2021.730982
Frontiers in Immunology
The transient receptor potential vanilloid 4 channel (TRPV4) is a non-selective cation channel that is widely expressed and activated by a range of stimuli. Amongst these stimuli, changes in cell volume feature as a prominent regulator of TRPV4 activ
Publikováno v:
Cells, Vol 10, Iss 165, p 165 (2021)
Toft-Bertelsen, T L & MacAulay, N 2021, ' TRPing to the Point of Clarity : Understanding the Function of the Complex TRPV4 Ion Channel ', Cells, vol. 10, no. 1, 165 . https://doi.org/10.3390/cells10010165
Cells
Toft-Bertelsen, T L & MacAulay, N 2021, ' TRPing to the Point of Clarity : Understanding the Function of the Complex TRPV4 Ion Channel ', Cells, vol. 10, no. 1, 165 . https://doi.org/10.3390/cells10010165
Cells
The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate array of stimuli, interacts with a multitude of proteins, and is modul
Autor:
David Križaj, Trine Lisberg Toft-Bertelsen, Michael H. Elliott, Nanna MacAulay, Paul S. Bernstein, Grace F. Hoffmann, Eric Enyong, Aruna Gorusupudi, Amy Lin, Monika Lakk
Publikováno v:
Lakk, M, Hoffmann, G F, Gorusupudi, A, Enyong, E, Lin, A, Bernstein, P S, Toft-Bertelsen, T, MacAulay, N, Elliott, M H & Krizaj, D 2021, ' Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension ', Journal of Lipid Research, vol. 62 . https://doi.org/10.1016/j.jlr.2021.100145
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100145-(2021)
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100145-(2021)
Despite the association of cholesterol with debilitating pressure-related diseases such as glaucoma, heart disease, and diabetes, its role in mechanotransduction is not well understood. We investigated the relationship between mechanical strain, free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23119ab11b5e4e46eed10a3e7a415f06
https://curis.ku.dk/ws/files/286483858/Membrane_cholesterol_regulates_TRPV4_function_cytoskeletal_expression_and_the_cellular_response_to_tension.pdf
https://curis.ku.dk/ws/files/286483858/Membrane_cholesterol_regulates_TRPV4_function_cytoskeletal_expression_and_the_cellular_response_to_tension.pdf
Autor:
Helle S. Waagepetersen, Trine Lisberg Toft-Bertelsen, Brian Roland Larsen, Nanna MacAulay, Himanshu Khandelia, Sofie K. Christensen
Publikováno v:
Toft-Bertelsen, T L, Larsen, B R, Christensen, S K, Khandelia, H, Waagepetersen, H S & MacAulay, N 2021, ' Clearance of activity-evoked K + transients and associated glia cell swelling occur independently of AQP4 : A study with an isoform-selective AQP4 inhibitor ', Glia, vol. 69, no. 1, pp. 28-41 . https://doi.org/10.1002/glia.23851
Toft-Bertelsen, T L, Larsen, B R, Christensen, S K, Khandelia, H, Waagepetersen, H S & MacAulay, N 2020, ' Clearance of activity-evoked K + transients and associated glia cell swelling occur independently of AQP4 : A study with an isoform-selective AQP4 inhibitor ', Glia, vol. 69, no. 1, pp. 28-41 . https://doi.org/10.1002/glia.23851
Toft-Bertelsen, T L, Larsen, B R, Christensen, S K, Khandelia, H, Waagepetersen, H S & MacAulay, N 2020, ' Clearance of activity-evoked K + transients and associated glia cell swelling occur independently of AQP4 : A study with an isoform-selective AQP4 inhibitor ', Glia, vol. 69, no. 1, pp. 28-41 . https://doi.org/10.1002/glia.23851
The mammalian brain consists of 80% water, which is continuously shifted between different compartments and cellular structures by mechanisms that are, to a large extent, unresolved. Aquaporin 4 (AQP4) is abundantly expressed in glia and ependymal ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f1b1389cee28e679c7dca53b89249a
https://findresearcher.sdu.dk:8443/ws/files/170699440/glia.23851.pdf
https://findresearcher.sdu.dk:8443/ws/files/170699440/glia.23851.pdf
Autor:
Mads Gravers Jeppesen, Trine Lisberg Toft-Bertelsen, Thomas Nitschke Kledal, Mette Marie Rosenkilde
The dire need for therapies against SARS-CoV-2 infections is obvious and inspires strategies of repurposing drugs approved for other indications. Current examples are remdesivir (originally developed for ebola treatment) and steroids (anti-inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cb30475836d043ada59f1edadf29017
https://doi.org/10.21203/rs.3.rs-121743/v1
https://doi.org/10.21203/rs.3.rs-121743/v1
Autor:
Trine Lisberg, Toft-Bertelsen, Brian Roland, Larsen, Sofie Kjellerup, Christensen, Himanshu, Khandelia, Helle S, Waagepetersen, Nanna, MacAulay
Publikováno v:
GliaREFERENCES. 69(1)
The mammalian brain consists of 80% water, which is continuously shifted between different compartments and cellular structures by mechanisms that are, to a large extent, unresolved. Aquaporin 4 (AQP4) is abundantly expressed in glia and ependymal ce