Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Trine Krogh‐Madsen"'
Publikováno v:
Frontiers in Physiology, Vol 8 (2018)
Dynamic clamp, a hybrid-computational-experimental technique that has been used to elucidate ionic mechanisms underlying cardiac electrophysiology, is emerging as a promising tool in the discovery of potential anti-arrhythmic targets and in pharmacol
Externí odkaz:
https://doaj.org/article/0ea4d51a30f84a319f332ff8fd449ee4
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
In silico cardiac myocyte models present powerful tools for drug safety testing and for predicting phenotypical consequences of ion channel mutations, but their accuracy is sometimes limited. For example, several models describing human ventricular e
Externí odkaz:
https://doaj.org/article/582cb2052ed644cda88a02e6e89bf906
Autor:
Willemijn Groenendaal, Francis A Ortega, Armen R Kherlopian, Andrew C Zygmunt, Trine Krogh-Madsen, David J Christini
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 4, p e1004242 (2015)
The traditional cardiac model-building paradigm involves constructing a composite model using data collected from many cells. Equations are derived for each relevant cellular component (e.g., ion channel, exchanger) independently. After the equations
Externí odkaz:
https://doaj.org/article/955d66251d1f439a96259fddd41f95af
Autor:
Ritu Kant, Zhaoyang Hu, Jaideep K Malhotra, Trine Krogh-Madsen, David J Christini, Paul M Heerdt, Geoffrey W Abbott
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82951 (2013)
Aging increases the risk of cardiac pathologies including atrial fibrillation and can alter myocardial responsiveness to therapeutic agents. Here, seeking molecular correlates of myocardial aging processes, we performed global "whole transcript" anal
Externí odkaz:
https://doaj.org/article/f402597591de49fbb3bba7b484b83cbb
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 2, p e1002390 (2012)
Atrial fibrillation, a common cardiac arrhythmia, often progresses unfavourably: in patients with long-term atrial fibrillation, fibrillatory episodes are typically of increased duration and frequency of occurrence relative to healthy controls. This
Externí odkaz:
https://doaj.org/article/d5e1779b4ad148299a55120c630d9782
Publikováno v:
British Journal of Pharmacology. 179:4829-4843
Before advancing to clinical trials, new drugs are screened for their pro-arrhythmic potential using a method that is overly conservative and provides limited mechanistic insight. The shortcomings of this approach can lead to the mis-classification o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71de19e623284d9942689c31f21774b6
https://doi.org/10.1111/bph.15915
https://doi.org/10.1111/bph.15915
Autor:
Eleonora Grandi, Manuel F. Navedo, Jeffrey J. Saucerman, Donald M. Bers, Nipavan Chiamvimonvat, Rose E. Dixon, Dobromir Dobrev, Ana M. Gomez, Osama F. Harraz, Bence Hegyi, David K. Jones, Trine Krogh‐Madsen, Walter Lee Murfee, Matthew A. Nystoriak, Nikki G. Posnack, Crystal M. Ripplinger, Rengasayee Veeraraghavan, Seth Weinberg
Publikováno v:
The Journal of Physiology.
This white paper is the outcome of the seventh UC Davis Cardiovascular Research Symposium on Systems Approach to Understanding Cardiovascular Disease and Arrhythmia. This biannual meeting aims to bring together leading experts in subfields of cardiov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ba9a2548e980f22fe8991e4232770a
https://doi.org/10.1113/jp284011
https://doi.org/10.1113/jp284011
Autor:
Alexander P. Clark, Michael Clerx, Siyu Wei, Chon Lok Lei, Teun P. de Boer, Gary R. Mirams, David J. Christini, Trine Krogh-Madsen
Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have become an essential tool to study arrhythmia mechanisms. Much of the foundational work on these cells, and the computational models built from the resultant data, has overlook
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00ed2bc62fb226b8bcd15bdcb5691ce2
https://doi.org/10.1101/2022.10.13.511949
https://doi.org/10.1101/2022.10.13.511949
Autor:
Linna Xu, Todd Evans, Clemens Steegborn, Geoffrey W. Abbott, Jim W. Cheung, Bruce B. Lerman, Craig T. Basson, James E. Ip, Jie Dai, Gianina Panaghie, Fabrice Jaffré, Trine Krogh-Madsen
Publikováno v:
Circ Arrhythm Electrophysiol
Background: The cellular mechanism of focal, idiopathic right ventricular outflow tract (RVOT) tachycardia is thought to be due to cAMP-mediated triggered activity. A potential molecular mechanism has not yet been determined. We identified and charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3d3af3206b330658914fed75b37c68
https://europepmc.org/articles/PMC8569928/
https://europepmc.org/articles/PMC8569928/