SAM68 directs STING signaling to apoptosis in macrophages

Autor: Demi van der Horst, Naziia Kurmasheva, Mikkel H. S. Marqvorsen, Sonia Assil, Anna H. F. Rahimic, Christoph F. Kollmann, Leandro Silva da Costa, Qi Wu, Jian Zhao, Eleonora Cesari, Marie B. Iversen, Fanghui Ren, Trine I. Jensen, Ryo Narita, Vivien R. Schack, Bao-cun Zhang, Rasmus O. Bak, Claudio Sette, Robert A. Fenton, Jacob G. Mikkelsen, Søren R. Paludan, David Olagnier

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)

Abstract DNA is a danger signal sensed by cGAS to engage signaling through STING to activate innate immune functions. The best-studied downstream responses to STING activation include expression of type I interferon and inflammatory genes, but STING

Externí odkaz: https://doaj.org/article/0db80e2a99374afa9c136a61eb6b74e2

Argonaute-associated short introns are a novel class of gene regulators

Autor: Thomas B. Hansen, Morten T. Venø, Trine I. Jensen, Anne Schaefer, Christian K. Damgaard, Jørgen Kjems

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

MicroRNAs are important small regulatory RNAs produced by sequential Drosha and Dicer cleavage. Here the authors describe 'agotrons', a subclass of small RNAs that bypass the canonical biogenesis machinery.

Externí odkaz: https://doaj.org/article/55b26c2c34fc488ba616354f17c51d20

CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses

Autor: Mingyu He, Kate Roussak, Feiyang Ma, Nicholas Borcherding, Vince Garin, Mike White, Charles Schutt, Trine I. Jensen, Yun Zhao, Courtney A. Iberg, Kairav Shah, Himanshi Bhatia, Daniel Korenfeld, Sabrina Dinkel, Judah Gray, Alina Ulezko Antonova, Stephen Ferris, David Donermeyer, Cecilia Lindestam Arlehamn, Matthew M. Gubin, Jingqin Luo, Laurent Gorvel, Matteo Pellegrini, Alessandro Sette, Thomas Tung, Rasmus Bak, Robert L. Modlin, Ryan C. Fields, Robert D. Schreiber, Paul M. Allen, Eynav Klechevsky

Publikováno v: He, M, Roussak, K, Ma, F, Borcherding, N, Garin, V, White, M, Schutt, C, Jensen, T I, Zhao, Y, Iberg, C A, Shah, K, Bhatia, H, Korenfeld, D, Dinkel, S, Gray, J, Ulezko Antonova, A, Ferris, S, Donermeyer, D, Lindestam Arlehamn, C, Gubin, M M, Luo, J, Gorvel, L, Pellegrini, M, Sette, A, Tung, T, Bak, R, Modlin, R L, Fields, R C, Schreiber, R D, Allen, P M & Klechevsky, E 2023, ' CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses ', Science, vol. 379, no. 6633, eabg2752 . https://doi.org/10.1126/science.abg2752

The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we show that human CD1c + CD5 + DCs are reduced in melanoma-affected lymph node

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb58f3075eb648887329399a6257400
https://pure.au.dk/portal/da/publications/cd5-expression-by-dendritic-cells-directs-t-cell-immunity-and-sustains-immunotherapy-responses(0a5862aa-3391-473b-9491-d06b9b57ccb2).html

Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi

Autor: Johannes Foßelteder, Anders Laustsen, Rasmus O. Bak, Nanna S. Mikkelsen, Gabriel Pabst, Trine I. Jensen, Saskia König, Andreas Reinisch, Esben Axelgaard, Zongliang Gao

Publikováno v: Jensen, T I, Mikkelsen, N S, Gao, Z, Foßelteder, J, Pabst, G, Axelgaard, E, Laustsen, A, König, S, Reinisch, A & Bak, R O 2021, ' Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi ', Genome Research, vol. 31, no. 11, pp. 2120-2130 . https://doi.org/10.1101/gr.275607.121

Targeted transcriptional activation or interference can be induced with the CRISPR-Cas9 system (CRISPRa/CRISPRi) using nuclease-deactivated Cas9 fused to transcriptional effector molecules. These technologies have been used in cancer cell lines, part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f1f6674666da5ae5d2ad22bdf2dd80
https://pubmed.ncbi.nlm.nih.gov/34407984

Argonaute-associated short introns are a novel class of gene regulators

Autor: Christian Kroun Damgaard, Trine I. Jensen, Morten T. Venø, Thomas B. Hansen, Anne Schaefer, Jørgen Kjems

Publikováno v: Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Hansen, T B, Venø, M T, Jensen, T I, Schaefer, A, Damgaard, C K & Kjems, J 2016, ' Argonaute-associated short introns are a novel class of gene regulators ', Nature Communications, vol. 7, 11538 . https://doi.org/10.1038/ncomms11538

MicroRNAs (miRNAs) are short (∼22 nucleotides) regulators of gene expression acting by direct base pairing to 3′-UTR target sites in messenger RNAs. Mature miRNAs are produced by two sequential endonucleolytic cleavages facilitated by Drosha in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f0dfd117fc216bf1951b3fc2946537
https://pubmed.ncbi.nlm.nih.gov/27173734