Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase.

Autor: Baliga RS, Milsom AB, Ghosh SM, Trinder SL, Macallister RJ, Ahluwalia A, Hobbs AJ, Baliga, Reshma S, Milsom, Alexandra B, Ghosh, Suborno M, Trinder, Sarah L, Macallister, Raymond J, Ahluwalia, Amrita, Hobbs, Adrian J

Publikováno v: Circulation; 6/12/2012, Vol. 125 Issue 23, p2922-2932, 11p

Selective deletion of connective tissue growth factor attenuates experimentally-induced pulmonary fibrosis and pulmonary arterial hypertension.

Autor: Tam AYY; Centre for Rheumatology and Connective Tissue Disease, Department of Inflammation, Division of Medicine, University College London, London, NW3 2PF, UK. Electronic address: angela.tam@ucl.ac.uk., Horwell AL; Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, L7 8TX, UK., Trinder SL; Centre for Rheumatology and Connective Tissue Disease, Department of Inflammation, Division of Medicine, University College London, London, NW3 2PF, UK., Khan K; Centre for Rheumatology and Connective Tissue Disease, Department of Inflammation, Division of Medicine, University College London, London, NW3 2PF, UK., Xu S; Centre for Rheumatology and Connective Tissue Disease, Department of Inflammation, Division of Medicine, University College London, London, NW3 2PF, UK., Ong V; Centre for Rheumatology and Connective Tissue Disease, Department of Inflammation, Division of Medicine, University College London, London, NW3 2PF, UK., Denton CP; Centre for Rheumatology and Connective Tissue Disease, Department of Inflammation, Division of Medicine, University College London, London, NW3 2PF, UK., Norman JT; Department of Renal Medicine, Division of Medicine, University College London, London, NW3 2PF, UK., Holmes AM; Centre for Rheumatology and Connective Tissue Disease, Department of Inflammation, Division of Medicine, University College London, London, NW3 2PF, UK., Bou-Gharios G; Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, L7 8TX, UK., Abraham DJ; Centre for Rheumatology and Connective Tissue Disease, Department of Inflammation, Division of Medicine, University College London, London, NW3 2PF, UK.

Publikováno v: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2021 May; Vol. 134, pp. 105961. Date of Electronic Publication: 2021 Mar 01.

Endothelial to Mesenchymal Transition Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension.

Autor: Good RB; Division of Medicine, University College London Medical School, Royal Free Campus, London, United Kingdom., Gilbane AJ; Division of Medicine, University College London Medical School, Royal Free Campus, London, United Kingdom., Trinder SL; Division of Medicine, University College London Medical School, Royal Free Campus, London, United Kingdom., Denton CP; Division of Medicine, University College London Medical School, Royal Free Campus, London, United Kingdom., Coghlan G; National Pulmonary Hypertension Service, Royal Free Hospital National Health Service Foundation Trust, London, United Kingdom., Abraham DJ; Division of Medicine, University College London Medical School, Royal Free Campus, London, United Kingdom., Holmes AM; Division of Medicine, University College London Medical School, Royal Free Campus, London, United Kingdom. Electronic address: alan.holmes@ucl.ac.uk.

Publikováno v: The American journal of pathology [Am J Pathol] 2015 Jul; Vol. 185 (7), pp. 1850-8. Date of Electronic Publication: 2015 May 05.

Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension.

Autor: Bubb KJ; From the William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London (K.J.B., S.L.T., R.S.B., A.J.H.); and Centre for Clinical Pharmacology, University College London (J.P., L.H.C., R.J.M.), London, United Kingdom., Trinder SL; From the William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London (K.J.B., S.L.T., R.S.B., A.J.H.); and Centre for Clinical Pharmacology, University College London (J.P., L.H.C., R.J.M.), London, United Kingdom., Baliga RS; From the William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London (K.J.B., S.L.T., R.S.B., A.J.H.); and Centre for Clinical Pharmacology, University College London (J.P., L.H.C., R.J.M.), London, United Kingdom., Patel J; From the William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London (K.J.B., S.L.T., R.S.B., A.J.H.); and Centre for Clinical Pharmacology, University College London (J.P., L.H.C., R.J.M.), London, United Kingdom., Clapp LH; From the William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London (K.J.B., S.L.T., R.S.B., A.J.H.); and Centre for Clinical Pharmacology, University College London (J.P., L.H.C., R.J.M.), London, United Kingdom., MacAllister RJ; From the William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London (K.J.B., S.L.T., R.S.B., A.J.H.); and Centre for Clinical Pharmacology, University College London (J.P., L.H.C., R.J.M.), London, United Kingdom., Hobbs AJ; From the William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London (K.J.B., S.L.T., R.S.B., A.J.H.); and Centre for Clinical Pharmacology, University College London (J.P., L.H.C., R.J.M.), London, United Kingdom. a.j.hobbs@qmul.ac.uk.

Publikováno v: Circulation [Circulation] 2014 Aug 05; Vol. 130 (6), pp. 496-507. Date of Electronic Publication: 2014 Jun 04.

Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension.

Autor: Derrett-Smith EC; University College London Medical School, Royal Free Campus, London, UK., Dooley A, Gilbane AJ, Trinder SL, Khan K, Baliga R, Holmes AM, Hobbs AJ, Abraham D, Denton CP

Publikováno v: Arthritis and rheumatism [Arthritis Rheum] 2013 Nov; Vol. 65 (11), pp. 2928-39.